Role of the CXCL12/CXCR4 axis in milky spots of rats bearing ascitic-type hepatoma.

Abstract:

:Rat ascitic-type hepatoma AH7974 cells express CXCR4 mRNA and protein at high levels and also show vigorous migratory responses to its ligand CXCL12. We have shown that AMD3100 (a specific CXCR4 antagonist) effectively reduced tumor invasion into the milky spot in Sprague-Dawley rats inoculated with AH7974 cells. A histological analysis revealed that the milky spots from AMD3100-treated rats were both smaller and consisted of fewer constituent cells and blood vessels than those from the AH7974 inoculated rats. Alkaline phosphatase staining also showed a statistically significant reduction in the area of the milky spots in the AMD3100-treated rats in comparison to the AH7974 inoculated rats (P < 0.0001). Green fluorescence protein (GFP)-tagged AH7974 cells were constructed to detect the localization of the tumor cells in the milky spots. There were fewer GFP-tagged AH7974 cells in the AMD3100-treated rats than in the AH7974 inoculated rats. The number of eosinophils and mast cells increased in the milky spots of AH7974-inoculated rats, and angiogenesis was also seen. In comparison, both cell proliferation and angiogenesis were inhibited in the milky spots of the AMD3100-treated rats. Collectively, our results strongly suggest that the CXCR4/CXCL12 axis plays an important role in the development of peritoneal carcinomatosis. As such, CXCR4 may be a potential therapeutic target for peritoneal carcinomatosis.

journal_name

Anat Sci Int

authors

Abe H,Ina K,Kitamura H,Sumiyoshi H,Tatsukawa S,Yoshioka H,Fujikura Y

doi

10.1007/s12565-009-0028-z

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

226-36

issue

3

eissn

1447-6959

issn

1447-073X

journal_volume

84

pub_type

杂志文章
  • Sex-based differences in human sacroiliac joint shape: a three-dimensional morphological analysis of the iliac auricular surface of modern Japanese macerated bones.

    abstract::The human pelvis is one of the skeletons where sex differences are expressed, but few detailed studies have been conducted on sex-related differences in the sacroiliac joint morphology. Therefore, we conducted a three-dimensional morphological analysis evaluation of the sacroiliac joints to clarify the sex-related dif...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-019-00513-2

    authors: Nishi K,Saiki K,Oyamada J,Okamoto K,Ogami-Takamura K,Hasegawa T,Moriuchi T,Sakamoto J,Higashi T,Tsurumoto T,Manabe Y

    更新日期:2020-03-01 00:00:00

  • Renin-angiotensin system in vertebrates: phylogenetic view of structure and function.

    abstract::Renin substrate, biological renin activity, and/or renin-secreting cells in kidneys evolved at an early stage of vertebrate phylogeny. Angiotensin (Ang) I and II molecules have been identified biochemically in representative species of all vertebrate classes, although variation occurs in amino acids at positions 1, 5,...

    journal_title:Anatomical science international

    pub_type: 杂志文章,评审

    doi:10.1007/s12565-016-0372-8

    authors: Nishimura H

    更新日期:2017-03-01 00:00:00

  • A new human cadaver model for laparoscopic training using N-vinyl-2-pyrrolidone: a feasibility study.

    abstract::The demand for cadavers for clinical skills training is increasing. However, conventional formalin-fixed bodies are often unsuitable for surgical training because the tissues become too hard. We recently developed a new formalin-free embalming method with N-vinyl-2-pyrrolidone (pyrrolidone) that has excellent fixative...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-019-00494-2

    authors: Nagase M,Kimoto Y,Sunami E,Matsumura G

    更新日期:2020-01-01 00:00:00

  • Implications for thymus growth in childhood: histogenesis of cortex and medulla.

    abstract::The increase in autoimmune diseases in recent years has drawn attention back to the thymus, with new approaches to improve and/or restore immune function being investigated. As the primary lymphoid organ responsible for functional T cell development, studies on the pre-/post-natal development of this organ and T lymph...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-018-0456-8

    authors: Ayran Fidan P,Kaymaz FF,Dagdeviren A

    更新日期:2019-01-01 00:00:00

  • Mathematical modelling of the growth of human fetus anatomical structures.

    abstract::The goal of this study was to present a procedure that would enable mathematical analysis of the increase of linear sizes of human anatomical structures, estimate mathematical model parameters and evaluate their adequacy. Section material consisted of 67 foetuses-rectus abdominis muscle and 75 foetuses- biceps femoris...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-016-0353-y

    authors: Dudek K,Kędzia W,Kędzia E,Kędzia A,Derkowski W

    更新日期:2017-09-01 00:00:00

  • The morphology and origin of the skeletal muscle bundles associated with the human mustache.

    abstract::The arrector pili muscle is a smooth muscle bundle that attaches to the bulge region of the hair follicle and extends to its superior attachment in the upper dermis or epidermis. However, the morphology and origin of the muscle associated with the human mustache is different, having a general smooth arrector pili musc...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-012-0133-2

    authors: Kim JN,Lee JY,Yoo JY,Paik DJ,Koh KS,Song WC

    更新日期:2012-09-01 00:00:00

  • Surgical anatomy of the perineal muscles and their role in perineal disorders.

    abstract::The anterior perineum contains the perineal body and muscles. It is the site of functional and pathological disorders, many of which have not yet been related to a precise cause. In the present study, we investigated the anatomy of the perineal muscles with the aim of elucidating their function in light of their anato...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1111/j.1447-073x.2005.00109.x

    authors: Shafik A,Ahmed I,Shafik AA,El-Ghamrawy TA,El-Sibai O

    更新日期:2005-09-01 00:00:00

  • Envisioning the inner body during the Edo period in Japan: Inshoku yojo kagami (Rules of Dietary Life) and Boji yojo kagami (Rules of Sexual Life).

    abstract::There are two ukiyoe, Japanese woodblock prints, that were produced around 1850 and give a good picture of the images of the insides of the human body that were widely accepted among the common people in the Edo period. The Inshoku yojo kagami (Rules of Dietary Life) shows a man drinking sake. The Boji yojo kagami (Ru...

    journal_title:Anatomical science international

    pub_type: 历史文章,杂志文章

    doi:10.1111/j.1447-073X.2006.00159.x

    authors: Shirasugi E

    更新日期:2007-03-01 00:00:00

  • Formic acid demineralization does not affect the morphometry of cervical zygapophyseal joint meniscoids.

    abstract::Demineralization can facilitate the dissection of soft tissue structures in inaccessible locations by softening surrounding bone so that it can be easily removed without risking damage to the structure of interest. However, it is unclear whether demineralization alters the morphometry of soft tissues if used for this ...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-014-0248-8

    authors: Farrell SF,Osmotherly PG,Rivett DA,Cornwall J

    更新日期:2015-01-01 00:00:00

  • Sunao Tawara : further musings on his tribulations in providing the basis for the modern-day understanding of cardiac electrophysiology.

    abstract::Sunao Tawara, who was born in 1873 and died in 1952, is considered the father of modern cardiac electrophysiology. He published his monumental monograph describing the atrioventricular conduction axis in 1906. He achieved this task in the face of multiple tribulations as a doctoral student working in a cultural enviro...

    journal_title:Anatomical science international

    pub_type: 传,历史文章,杂志文章

    doi:10.1007/s12565-020-00530-6

    authors: De Almeida MC,Sanchez-Quintana D,Anderson RH

    更新日期:2020-06-01 00:00:00

  • Plastic casts and confocal laser scanning microscopy applied to the observation of enamel tubules in the red Kangaroo (Macropus rufus).

    abstract::Scanning electron microscopy for plastic casts and confocal laser scanning microscopy for Villanueva bone-stained ground sections were used together to observe enamel tubules in red kangaroo molars. Although the tubular structures such as terminals, bends, expansions, splits, divergences and rejoinings in this species...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1046/j.0022-7722.2003.00039.x

    authors: Suzuki M,Ushijima N,Kohno A,Sawa Y,Yoshida S,Sekikawa M,Ohtaishi N

    更新日期:2003-03-01 00:00:00

  • A case of right partial and double internal jugular veins.

    abstract::We present a very rare case of right partial and double internal jugular veins, found in an 86-year-old Japanese female cadaver during a student dissection practice session in 2002 at Osaka Dental University. In this case, the right internal jugular vein separated into medial and lateral branches at a level with the m...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1111/j.1447-073X.2006.00119.x

    authors: Uemura M,Takemura A,Tamada Y,Toda I,Ike H,Suwa F

    更新日期:2006-03-01 00:00:00

  • A multitude of variations in the configuration of the circle of Willis: an autopsy study.

    abstract::The circle of Willis (CW) is an anastomotic system of arteries located at the base of the brain. The aim of the study was to evaluate the anatomic configuration of the CW in the Polish population and to compare results with previously conducted research. Brains were obtained from 100 recently deceased human adults, an...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-015-0301-2

    authors: Klimek-Piotrowska W,Rybicka M,Wojnarska A,Wójtowicz A,Koziej M,Hołda MK

    更新日期:2016-09-01 00:00:00

  • Divided and reunited maxillary artery: developmental and clinical considerations.

    abstract::We describe an anatomical variation of the right maxillary artery, discovered during dissection of a male human cadaver. The right maxillary artery bifurcates into unequal superficial (larger) and deep (smaller) divisions. Each division gives off several branches that distribute to the muscles of mastication, facial s...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-011-0106-x

    authors: Claire PG,Gibbs K,Hwang SH,Hill RV

    更新日期:2011-12-01 00:00:00

  • Topographical relationship between the accessory hepatic duct and the hepatic artery system.

    abstract::Hepatic biliary injury is one of the most common complications in cholecystectomy and is frequently accompanied by arterial injuries. Because there are several anatomical variations of the hepatic ducts, including the accessory hepatic ducts (AHDs), it is important to consider not only the anatomical position of the h...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-020-00568-6

    authors: Tanaka T,Nakada T,Ito T,Kominami R,Sonomura T,Kagaya M,Kawai K,Honma S

    更新日期:2021-01-01 00:00:00

  • Accessory lumbar splanchnic ganglia in humans: a case report.

    abstract::The present study was designed and performed on 20 human adult cadavers at the level of the retroperitoneal space in order to provide evidence of the paravertebral and prevertebral sympathetic ganglia. Only one specimen, male, presented two ganglia on the left side located on the first lumbar splanchnic nerve, one pro...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-008-0012-z

    authors: Rusu MC

    更新日期:2009-09-01 00:00:00

  • Thiel's embalming method with additional intra-cerebral ventricular formalin injection (TEIF) for cadaver training of head and brain surgery.

    abstract::Thiel's embalming method provides natural coloration, flexibility, and tissue plasticity, and is used widely to prepare specimens for cadaver surgical training. However, this method causes brain softening, thereby restricting the cadaver surgical training of intra-cranial procedures. In this study, three cadavers were...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-020-00545-z

    authors: Miyake S,Suenaga J,Miyazaki R,Sasame J,Akimoto T,Tanaka T,Ohtake M,Takase H,Tateishi K,Shimizu N,Murata H,Funakoshi K,Yamamoto T

    更新日期:2020-09-01 00:00:00

  • Molecular embryology for an understanding of congenital heart diseases.

    abstract::Congenital heart diseases (CHD) result from abnormal morphogenesis of the embryonic cardiovascular system and usually involve defects in specific structural components of the developing heart and vessels. Therefore, an understanding of "Molecular Embryology", with specific focus on the individual modular steps involve...

    journal_title:Anatomical science international

    pub_type: 杂志文章,评审

    doi:10.1007/s12565-009-0023-4

    authors: Yamagishi H,Maeda J,Uchida K,Tsuchihashi T,Nakazawa M,Aramaki M,Kodo K,Yamagishi C

    更新日期:2009-09-01 00:00:00

  • Prenatal stress induces learning deficits and is associated with a decrease in granules and CA3 cell dendritic tree size in rat hippocampus.

    abstract::Exposure to gestational stress impairs hippocampal-dependent learning in offspring. In spite of the known decisive role of hippocampal dendritic architecture in learning and memory, there has been no study to date that examines the effect of prenatal stress on the morphology of the hippocampal neurons. Therefore we pe...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1111/j.1447-073X.2007.00186.x

    authors: Hosseini-Sharifabad M,Hadinedoushan H

    更新日期:2007-12-01 00:00:00

  • Surgical relevance of the lateral costotransverse ligament in relation to the dorsal root ganglion.

    abstract::The lateral costotransverse ligament, a short band that stabilizes the costovertebral joint, is found in close proximity to the dorsal root ganglion. This ligament is an important surgical landmark during tumor resections or nerve blocks in the paravertebral space. The purpose of this study was to quantitatively and q...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-016-0381-7

    authors: D'Antoni AV,Collin PG,Graham RA,Kennedy HM,Ndjatou T,Perez P,Tubbs RS,Loukas M,Kozlowski PB,Mtui EP

    更新日期:2018-01-01 00:00:00

  • Superficial palmar arch completion at the first interdigital cleft: a case report.

    abstract::Knowledge of variations in the formation of superficial palmar arch is beneficial for successful vascular surgery in the hand as well as for plastic surgeons. The authors describe an unusual completion of superficial palmar arch by first dorsal metacarpal branch of radial artery at the first interdigital cleft which w...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-012-0130-5

    authors: Rai R,Prabhu LV,Yadav A,Rao CP,Tonse M,Virupakshamurthy MB

    更新日期:2013-03-01 00:00:00

  • The olfactory bulb structure of African giant rat (Cricetomys gambianus, Waterhouse 1840) I: cytoarchitecture.

    abstract::The olfactory system typically consists of two parallel systems: the main olfactory system and the accessory olfactory system. The main olfactory bulb (MOB) acts as the initial processing site for volatile chemical stimuli and receives input from the olfactory receptor cells located in the olfactory epithelium. The Af...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-014-0227-0

    authors: Olude MA,Ogunbunmi TK,Olopade JO,Ihunwo AO

    更新日期:2014-09-01 00:00:00

  • Claw development and cornification in the passeraceous bird zebrafinch (Taeniatopygia guttata castanotis).

    abstract::The histogenesis and cornification of claws in zebrafinch embryos has been analyzed. At 10-12 days post-deposition, the epidermis at the tip of the toes forms placode-like anlage associated with a mesenchymal condensation and with a terminal phalange. Claws seem to be modified scales, the dorsal side of which becomes ...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-009-0015-4

    authors: Alibardi L

    更新日期:2009-09-01 00:00:00

  • Variations of the hepatobiliary vasculature including coexistence of accessory right hepatic artery with unusually arising double cystic arteries: case report and literature review.

    abstract::Familiarity with the different anatomical variations of the arterial supply of the gallbladder and liver is of great importance in all hepatobiliary surgical procedures. A complex anomaly of the hepatobiliary arterial system, which has never been reported before, was found during anatomical dissection of a 73-year-old...

    journal_title:Anatomical science international

    pub_type: 杂志文章,评审

    doi:10.1007/s12565-013-0219-5

    authors: Polguj M,Podgórski M,Hogendorf P,Topol M

    更新日期:2014-06-01 00:00:00

  • Visualization of spatiotemporal differentiation of dopaminergic interneurons in adult mouse olfactory bulb using transgenic mice.

    abstract::Olfactory bulb (OB) interneurons, predominantly periglomerular (PG) and granule (GR) cells, are derived from neural stem cells in the subventricular zone (SVZ) throughout life and migrate to the OB in the rostral migratory stream (RMS). In the adult superficial GR layer transgene expression was found, either enhanced ...

    journal_title:Anatomical science international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1447-073X.2007.00209.x

    authors: Saino-Saito S

    更新日期:2008-12-01 00:00:00

  • Anatomical landmarks: dimensions of the mastoid air cell system in the Mediterranean population. Our experience from the anatomy of 298 temporal bones.

    abstract::The mastoid apophysis originates from a recent phylogenetic formation, associated with the standing attitude and it is currently considered as an evolution of the bone super-structures. The aim of the present study was to measure the diameters of the mastoid and the temporal bone in the Greek adult population. A total...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1111/j.1447-073X.2007.00175.x

    authors: Manolis E,Filippou D,Theocharis S,Panagiotaropoulos T,Lappas D,Mompheratou E

    更新日期:2007-09-01 00:00:00

  • Persistent hypoglossal artery with hypoplasia of the vertebral and posterior communicating arteries.

    abstract::We observed a rare case of the right persistent hypoglossal artery (PHA) in the posterior cranial fossa of a deceased 74-year-old Japanese man who did not have any clinical manifestations related to this anomaly when alive. The large-sized PHA originating from the cervical internal carotid artery passed through the hy...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-009-0062-x

    authors: Terayama R,Toyokuni Y,Nakagawa S,Nakatsuji K,Nakama H,Yamaai T,Ichikawa H,Sugimoto T

    更新日期:2011-03-01 00:00:00

  • Neuroprotective effect of regular swimming exercise on calretinin-positive striatal neurons of Parkinsonian rats.

    abstract::In Parkinson's disease (PD), physical therapy is one of the mainstays of supportive treatment modalities. This study focused on the neuroprotective effect of regular exercise on striatal calretinin positive interneurons in a rat model of PD. 6-hydroxydopamine (6-OHDA) was injected unilaterally into the medial forebrai...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-020-00538-y

    authors: Boracı H,Kirazlı Ö,Gülhan R,Yıldız Sercan D,Şehirli ÜS

    更新日期:2020-09-01 00:00:00

  • Four-headed biceps and triceps brachii muscles, with neurovascular variation.

    abstract::Anatomical variations of the biceps brachii and triceps brachii have been described by various authors, but the occurrence of four-headed biceps brachii and triceps brachii in an ipsilateral arm is rare and has not been reported before in the literature. During routine cadaveric dissection in the department of anatomy...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1111/j.1447-073X.2007.00171.x

    authors: Nayak SR,Krishnamurthy A,Kumar M,Prabhu LV,Saralaya V,Thomas MM

    更新日期:2008-06-01 00:00:00

  • What comprises the plate-like structure between the pancreatic head and the celiac trunk and superior mesenteric artery? A proposal for the term "P-A ligament" based on anatomical findings.

    abstract::A plate-like structure is located posterior to the portal vein system, between the pancreatic head and roots and/or branches of two major arteries of the aorta: the celiac trunk and superior mesenteric artery. We aimed to clarify the distribution and components of this plate-like structure. Macroscopic examination of ...

    journal_title:Anatomical science international

    pub_type: 杂志文章

    doi:10.1007/s12565-020-00597-1

    authors: Muro S,Sirirat W,Ban D,Nagakawa Y,Akita K

    更新日期:2021-01-08 00:00:00