Abstract:
:Congenital heart diseases (CHD) result from abnormal morphogenesis of the embryonic cardiovascular system and usually involve defects in specific structural components of the developing heart and vessels. Therefore, an understanding of "Molecular Embryology", with specific focus on the individual modular steps involved in cardiovascular morphogenesis, is particularly relevant to those wishing to have a better insight into the origin of CHD. Recent advances in molecular embryology suggest that the cardiovascular system arises from multiple distinct embryonic origins, and a population of myocardial precursor cells in the pharyngeal mesoderm anterior to the early heart tube, denoted the "second heart field", has been identified. Discovery of the second heart field has important implications for the interpretation of cardiac outflow tract development and provides new insights into the morphogenesis of CHD.
journal_name
Anat Sci Intjournal_title
Anatomical science internationalauthors
Yamagishi H,Maeda J,Uchida K,Tsuchihashi T,Nakazawa M,Aramaki M,Kodo K,Yamagishi Cdoi
10.1007/s12565-009-0023-4subject
Has Abstractpub_date
2009-09-01 00:00:00pages
88-94issue
3eissn
1447-6959issn
1447-073Xjournal_volume
84pub_type
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