Abstract:
BACKGROUND:To reduce the risk of brain damage children with acute lymphoblastic leukaemia (ALL) are nowadays mainly treated with intrathecal chemotherapy (ITC) instead of central nervous system (CNS) radiation therapy (CRT) to prevent CNS relapse. However, chemotherapy may also lead to cognitive deficits. As growth hormone deficiency (GHD) or impaired growth hormone secretion are frequently found in ALL patients treated with cranial radiation therapy and/or chemotherapy, we hypothesized that GH therapy may reduce cognitive deficits in these patients. METHODS:Twenty young adult survivors of childhood ALL with reduced bone mineral density (<-1 SD) and/or low IGF-I SD-scores (<-1 SD) were included in the study. A final group of 13 patients (9 males and 4 females), mean age 23.7 +/- 2.9 years (range 20 - 29.7) completed a 2-year treatment with GH.IQ and neuropsychological performance were assessed at pre-treatment (T1) and after one (T2) and two (T3) years. ANOVA was performed with assessment at T1, T2 and T3 as repeated measurements factor. Relations between test score changes and changes of IGF-I levels were determined by calculating the Pearson correlation coefficient. RESULTS:Scores on the cognitive tests were in the normal range. Verbal short- and long-term memory performance decreased between T1 and T2, and increased between T2 and T3. Performance at T3 was not significantly different from that at T1. Performance for sustained attention improved from T1 to T2 and from T1 to T3. Visual-spatial memory was improved after one year of GH treatment. A significant positive correlation was found for Delta IGF-I (T2-T1) with difference scores of visual-spatial memory (T2-T1 and T3-T1), indicating that IGF-I increase after one year of GH treatment is associated with increase in cognitive-perceptual performance at month 12 and 24. CONCLUSION:Since the level of intellectual functioning of our patient cohort was in the normal range the present finding that GH treatment has negative effects on verbal memory and positive on attention and visual-spatial memory warrants similar studies in other groups of ALL survivors. Also, a lower dose of GH should be determined inducing as much IGF as needed to improve verbal as well as visual cognitive functions. The present findings indicate that more knowledge is needed before GH treatment may be recommended to enhance cognitive functions in ALL survivors.
journal_name
BMC Pediatrjournal_title
BMC pediatricsauthors
Huisman J,Aukema EJ,Deijen JB,van Coeverden SC,Kaspers GJ,van der Pal HJ,Delemarre-van de Waal HAdoi
10.1186/1471-2431-8-25subject
Has Abstractpub_date
2008-06-20 00:00:00pages
25issn
1471-2431pii
1471-2431-8-25journal_volume
8pub_type
临床试验,杂志文章相关文献
BMC Pediatrics文献大全abstract:BACKGROUND:Ultrasonography of the hip has gained wide acceptance as a primary method for diagnosis, screening and treatment monitoring of developmental hip dysplasia in infants. The aim of the study was to examine the degree of concordance of two objective classifications of hip morphology and subjective parameters by ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-10-98
更新日期:2010-12-24 00:00:00
abstract:BACKGROUND:Non-Hispanic black (NHB) infants are twice as likely as non-Hispanic white infants to experience rapid weight gain in the first 6 months, yet few trials have targeted this population. The current study tests the efficacy of "Mothers & Others," a home-based intervention for NHB women and their study partners ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02273-9
更新日期:2020-08-18 00:00:00
abstract:BACKGROUND:Detection of a heart murmur in healthy children is common, but may generate anxiety among parents. Many parents believe a heart murmur is a sign of heart disease, although the majority of heart murmurs are innocent. The purpose of this study was to assess anxiety and concerns in parents of children referred ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-015-0507-4
更新日期:2015-11-21 00:00:00
abstract:BACKGROUND:Reference values for hematological and biochemical assays in pregnant women and in newborn infants are based primarily on Caucasian populations. Normative data are limited for populations in sub-Saharan Africa, especially comparing women with and without HIV infection, and comparing infants with and without ...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2431-9-49
更新日期:2009-08-07 00:00:00
abstract:BACKGROUND:The Cochrane Neonatal Review Group (CNRG) has achieved a lot with limited resources in producing high quality systematic reviews to assist clinicians in evidence-based decision-making. A formal assessment of published CNRG systematic reviews has not been undertaken; we sought to provide a comprehensive asses...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-9-38
更新日期:2009-06-17 00:00:00
abstract:BACKGROUND:Increased survival of extremely low birth infants due to advances in antenatal and neonatal care has resulted in a population of infants at high risk of developing retinopathy of prematurity (ROP). Therapeutic interventions include the use of antenatal and postnatal steroids however, their effects on the sev...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-5-18
更新日期:2005-06-28 00:00:00
abstract:BACKGROUND:Type 1 diabetes occurs more frequently in younger children who are often pre-school age and enter the education system with diabetes-related support needs that evolve over time. It is important that children are supported to optimally manage their diet, exercise, blood glucose monitoring and insulin regime a...
journal_title:BMC pediatrics
pub_type: 杂志文章,评审
doi:10.1186/1471-2431-14-228
更新日期:2014-09-12 00:00:00
abstract:BACKGROUND:Arthrogryposis multiplex congenita is an etiopathogenetically heterogeneous disorder characterised by non-progressive multiple intra-articular contractures, which can be recognised at birth. The frequency is estimated at 1 in 3,000 newborns. Etiopathogenesis of arthrogryposis is multifactorial. CASE PRESENT...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-13-184
更新日期:2013-11-11 00:00:00
abstract:BACKGROUND:Measuring adolescents' preferences for health states can play an important role in evaluating the delivery of pediatric healthcare. However, formal evaluation of the common direct preference elicitation methods for health states has not been done with adolescents. Therefore, the purpose of this study is to t...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1179-7
更新日期:2018-06-22 00:00:00
abstract:BACKGROUND:Considerable heterogeneity has been observed in the selection and reporting of disease-specific pediatric outcome measures in randomized controlled trials (RCTs). This makes interpretation of results and comparison across trials challenging. Outcome measures in pediatric anaphylaxis trials have never previou...
journal_title:BMC pediatrics
pub_type: 杂志文章,评审
doi:10.1186/1471-2431-14-158
更新日期:2014-06-20 00:00:00
abstract:BACKGROUND:Acute appendicitis (AA) is the most common surgical condition in children. Although a higher incidence of AA in summer has been reported, the reason for this observation remains unclear. The purpose of this study was to compare the clinical findings of AA patients who underwent appendectomies during the summ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1824-9
更新日期:2019-11-16 00:00:00
abstract:BACKGROUND:Early diagnosis and treatment are improving significantly the quality of life of patients with cystic fibrosis (CF). This recessive disease is caused by a great variability of mutations in the CF transmembrane conductance (CFTR) gene, whose spectrum and frequency can be different across populations. METHODS...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1903-y
更新日期:2020-01-03 00:00:00
abstract:BACKGROUND:Despite the need to identify the causes of disparities in childhood obesity, the existing epidemiologic studies of early life risk factors have several limitations. We report on the construction of the Linked CENTURY database, incorporating CENTURY (Collecting Electronic Nutrition Trajectory Data Using Recor...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-016-0567-0
更新日期:2016-03-09 00:00:00
abstract:BACKGROUND:Numerous studies have detailed the physical health benefits of children's participation in sport and a growing body of research also highlights the benefits for mental health. Children who participate in sport have also been shown to be advantaged academically. However, despite the benefits there is evidence...
journal_title:BMC pediatrics
pub_type: 杂志文章,评审
doi:10.1186/s12887-018-1014-1
更新日期:2018-02-09 00:00:00
abstract:BACKGROUND:Knowledge about psychometric properties of the Pediatric Quality of Life Inventory (PedsQL) in the Netherlands is limited and Dutch reference data are lacking. Aim of the current study is to collect Dutch reference data of the PedsQL and subsequently assess reliability, socio-demographic within-group differe...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-9-68
更新日期:2009-11-03 00:00:00
abstract:BACKGROUND:Most extremely low gestational age neonates (ELGANS, postmenstrual age at birth (PMA) < 28 completed weeks) require supplemental oxygen and experience frequent intermittent hypoxemic and hyperoxemic episodes. Hypoxemic episodes and exposure to inadequately high concentrations of oxygen are associated with an...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1735-9
更新日期:2019-10-21 00:00:00
abstract:BACKGROUND:Invasive S. pyogenes diseases are uncommon, serious infections with high case fatality rates (CFR). There are few publications on this subject in the field of pediatrics. This study aimed at characterizing clinical and laboratory aspects of this disease in Chinese children. PATIENTS AND METHODS:A retrospect...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/s12887-019-1536-1
更新日期:2019-06-05 00:00:00
abstract:BACKGROUND:Coxsackievirus A6 (CVA6) is one of the major agents to cause hand, foot and mouth disease (HFMD) outbreaks globally. The objective of this study is to investigate the epidemiologic and clinical manifestations of CVA6 outbreak, and thus guide the diagnosis and treatment of the disease, as well as disease prev...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1253-1
更新日期:2018-08-21 00:00:00
abstract:BACKGROUND:Poor sleep contributes to the developmental problems seen in preterm infants. We evaluated sleep problems in preterm infants 6 months of post-gestational age using the subjective Brief Infant Sleep Questionnaire (BISQ) and objective sleep tests. We also compared the sleep of premature infants with that of fu...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-014-0303-6
更新日期:2014-12-16 00:00:00
abstract:BACKGROUND:Tympanic thermometry has come as a suitable alternative to traditional thermometry because of its safety and ease of use. However, it is still yet to gain wide acceptance in African settings due to conflicting results on its accuracy, thus rectal thermometry remains the gold standard in the newborn. The aim ...
journal_title:BMC pediatrics
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2431-12-86
更新日期:2012-06-25 00:00:00
abstract:BACKGROUND:The human foot is shaped throughout all life in a way that is individual for every human being. Footwear fitting in the process of foot development is the issue covered by a limited range of empirical studies. This prompted the authors to undertake this subject of the study aimed at the influence of fitting ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02245-z
更新日期:2020-07-20 00:00:00
abstract:BACKGROUND:There is growing concern as regards the emergence of metabolic disorders among children living with the Human Immunodeficiency Virus (HIV) worldwide. However, there is paucity of data on the correlates of metabolic indices among HIV-positive children in Africa. METHODS:This study examined 84 HIV-positive ch...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02335-y
更新日期:2020-10-02 00:00:00
abstract:BACKGROUND:This study aimed to investigate intima-media thickness (IMT) of the common carotid arteries in children with acute Kawasaki disease (KD). METHODS:Between 2009 and 2011, patients fulfilling the criteria for KD, including a fever lasting >5 days, were prospectively enrolled in this study. Laboratory data, ech...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-14-98
更新日期:2014-04-10 00:00:00
abstract:BACKGROUND:Clostridium perfringens forms part of the human gut microbiota and has been associated with life-threatening necrotising enterocolitis (NEC) in premature infants. Whether specific toxigenic strains are responsible is unknown, as is the extent of diversity of strains in healthy premature babies. We investigat...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-1976-7
更新日期:2020-02-18 00:00:00
abstract:OBJECTIVE:It has been established that genetic factors play a substantial role in the development of neonatal hyperbilirubinemia. The population of Indonesia and other Southeast Asian countries has similar, yet different genetic makeup compared to the rest of Asia. Aside from UGT1A1, variants of SLCO1B1 have also been ...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/s12887-019-1589-1
更新日期:2019-06-28 00:00:00
abstract:BACKGROUND:Asthma is the most common chronic childhood illness, with rapidly increasing prevalence in low-income countries. Among young children, asthma is often under-diagnosed.We investigated the factors associated with asthma among under-fives presenting with acute respiratory symptoms at Mulago hospital, Uganda. M...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-13-141
更新日期:2013-09-11 00:00:00
abstract:BACKGROUND:Exposure of red blood cells to oxidants increases production of methemoglobin (MHb) resulting in impaired oxygen delivery to tissues. There are no reliable estimates of methemoglobinemia in low resource clinical settings. Our objectives were to: i) evaluate risk factors for methemoglobinemia in Ugandan child...
journal_title:BMC pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12887-016-0719-2
更新日期:2016-11-04 00:00:00
abstract:BACKGROUND:Maintaining and building healthy bones during the lifetime requires a complicated interaction between a number of physiological and lifestyle factors. Our goal of this study was to analyze the association between hand grip strength and the maximum peak expiratory flow with bone mineral density and content in...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1015-0
更新日期:2018-03-02 00:00:00
abstract:BACKGROUND:There is a lack of understanding of the factors that influence independent mobility and participation in meaningful activities. The purpose of this study was to analyse physical factors influencing independent use of manual and power wheelchairs in a total population of children with cerebral palsy (CP). ME...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-016-0707-6
更新日期:2016-10-10 00:00:00
abstract:BACKGROUND:The COVID-19 pandemic has disrupted healthcare systems worldwide. In addition to the direct impact of the virus on patient morbidity and mortality, the effect of lockdown strategies on health and healthcare utilization have become apparent. Little is known on the effect of the pandemic on pediatric and adole...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02303-6
更新日期:2020-09-07 00:00:00