Abstract:
BACKGROUND:Coxsackievirus A6 (CVA6) is one of the major agents to cause hand, foot and mouth disease (HFMD) outbreaks globally. The objective of this study is to investigate the epidemiologic and clinical manifestations of CVA6 outbreak, and thus guide the diagnosis and treatment of the disease, as well as disease prevention. METHODS:An HFMD outbreak in a kindergarten was reported to Shijingshan District Center for Disease Control and Prevention (SCDC) on November 2, 2015 in Beijing, China. Epidemiological investigation was conducted. We performed a nine-week follow-up study to collect and analyze the clinical manifestations of HFMD cases. RESULTS:The outbreak yield 56 (15.7%) clinical diagnosed HFMD cases out of 357 registered children in the kindergarten with the mean age of 3.5 years old. This outbreak lasted for three days and ceased after initiating infectious disease controlling procedures, including periodical suspension of the kindergarten activities, environmental disinfection, and family health education. Fifty-one cases were followed for nine weeks. The positive rate of clinical manifestations of rash, fever, desquamation, pigmentation and onychomadesis were 100.0%, 84.3%, 68.6%, 17.6% and 43.1%, respectively. Children developed desquamation within the first 4 weeks after disease onset and developed onychomadesis between the 3th and 8th week after disease onset. Children with desquamation had 9.3 (95%CI: 1.836-47.437) times higher odds of developing onychomadesis compared to those without this manifestation. Ten out of 14 collected samples were CVA6 positive, and five positive samples shared a high degree of similarity in the VP1 nucleotide and amino acid sequences (99.9-100.0% and 100%). CONCLUSION:This HFMD outbreak was caused by CVA6, featured with delayed symptoms. Emerging CVA6-associated HFMD and its delayed symptoms should be paid more attention to reduce outbreaks and provide more information to doctors and parents.
journal_name
BMC Pediatrjournal_title
BMC pediatricsauthors
Li J,Zhu R,Huo D,Du Y,Yan Y,Liang Z,Luo Y,Yang Y,Jia L,Chen L,Wang Q,He Ydoi
10.1186/s12887-018-1253-1subject
Has Abstractpub_date
2018-08-21 00:00:00pages
277issue
1issn
1471-2431pii
10.1186/s12887-018-1253-1journal_volume
18pub_type
杂志文章相关文献
BMC Pediatrics文献大全abstract:BACKGROUND:Although breastfeeding duration in New Zealand's indigenous Māori is shorter than in non-Māori, we know little about barriers or motivators of breastfeeding in this community. The aim of this analysis was to identify predictors for extended duration of breastfeeding amongst participants drawn from predominan...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1274-9
更新日期:2018-09-12 00:00:00
abstract:BACKGROUND:Urinary tract infection (UTI) is one of most common pediatric infections. The study was designed to assess the clinical profile, common bacterial microorganisms causing UTI and their antimicrobial susceptibility patterns at B. P. Koirala Institute of Health Sciences (BPKIHS) hospital. METHODS:This is a pros...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1410-1
更新日期:2019-01-29 00:00:00
abstract:BACKGROUND:Bronchopulmonary dysplasia (BPD) is a major cause of mortality and long-term respiratory and neurological morbidity in very preterm infants. While survival rates of very preterm infants have increased over the past two decades there has been no decrease in the rate of BPD in surviving infants. Evidence from ...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/s12887-016-0611-0
更新日期:2016-06-01 00:00:00
abstract:BACKGROUND:Paediatric end-of-life care is challenging and requires a high level of professional expertise. It is important that healthcare teams have a thorough understanding of paediatric subspecialties and related knowledge of disease-specific aspects of paediatric end-of-life care. The aim of this study was to compr...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1021-2
更新日期:2018-02-16 00:00:00
abstract:BACKGROUND:Caste, a proxy of socioeconomic position, can influence the neurodevelopment of children through several pathways, including exposure to toxic elements. Studies from developing countries where caste is represented by prevailing caste groups and people are highly exposed to toxic elements can provide useful i...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-14-56
更新日期:2014-02-27 00:00:00
abstract:BACKGROUND:Few studies address the use of paediatric highly active antiretroviral therapy (HAART) in Africa. METHODS:We performed a retrospective cohort study to investigate preliminary outcomes of all children eligible for HAART at Sinikithemba HIV/AIDS clinic in KwaZulu-Natal, South Africa. Immunologic, virologic, c...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-7-13
更新日期:2007-03-17 00:00:00
abstract:BACKGROUND:Clinical factors that affect the likelihood of abuse in children with femur fractures have not been well elucidated. Consequently, specifying which children with femur fractures warrant an abuse evaluation is difficult. Therefore the purpose of this study is to estimate the proportion of femur fractures in y...
journal_title:BMC pediatrics
pub_type: 杂志文章,评审
doi:10.1186/1471-2431-14-169
更新日期:2014-07-02 00:00:00
abstract:BACKGROUND:Improved referral algorithms for children with non-severe pneumonia at the community level are desirable. We sought to identify predictors of oral antibiotic failure in children who fulfill the case definition of World Health Organization (WHO) non-severe pneumonia. Predictors of greatest interest were those...
journal_title:BMC pediatrics
pub_type: 杂志文章,评审
doi:10.1186/s12887-015-0392-x
更新日期:2015-07-09 00:00:00
abstract:BACKGROUND:Most extremely low gestational age neonates (ELGANS, postmenstrual age at birth (PMA) < 28 completed weeks) require supplemental oxygen and experience frequent intermittent hypoxemic and hyperoxemic episodes. Hypoxemic episodes and exposure to inadequately high concentrations of oxygen are associated with an...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1735-9
更新日期:2019-10-21 00:00:00
abstract:BACKGROUND:Prompt initiation of empiric therapy is common practice in case of suspected meningitis or encephalitis. However, in children the most common pathogens are viruses that usually do not require and are not covered by the applied anti-infective treatment. Novel multiplex PCR (mPCR) panels provide rapid on-site ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-1944-2
更新日期:2020-02-05 00:00:00
abstract:BACKGROUND:Daily pain and multi-site pain are both associated with reduction in work ability and health-related quality of life (HRQoL) among adults. However, no population-based studies have yet investigated the prevalence of daily and multi-site pain among adolescents and how these are associated with respondent char...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-13-191
更新日期:2013-11-19 00:00:00
abstract:BACKGROUND:In preterm infants with Respiratory Distress Syndrome (RDS), Less Invasive Surfactant Administration (LISA) has been established to reduce the need of mechanical ventilation and might improve survival rates without bronchopulmonary dysplasia. The aim of this study was to investigate whether NICU care has cha...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02325-0
更新日期:2020-09-03 00:00:00
abstract:BACKGROUND:This study determined if the body mass index, dynamic plantar-pressures, plantar surface contact-area, velocity of the centre of pressure (COP), gastrocnemius equinus, and gastrocnemius soleus equines are related to calcaneal apophysitis (Sever's disease) in athletic children. METHODS:This case-control stud...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1318-1
更新日期:2018-11-19 00:00:00
abstract::After publication of the original article [1] it was brought to our attention that author Bouchra Ouled Amar Bencheikh was incorrectly included as Bouchra Oulad Amar Bencheikh. ...
journal_title:BMC pediatrics
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12887-018-1114-y
更新日期:2018-04-17 00:00:00
abstract:BACKGROUND:Establishing healthy physical activity (PA) behaviours in early childhood is important for future PA behaviours. Parents play a central role in young children's PA. However, there is currently little research on parenting interventions to increase child PA. This study was formative work to inform the content...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-12-180
更新日期:2012-11-20 00:00:00
abstract:BACKGROUND:This randomized controlled trial aims to evaluate the effects of an early developmental intervention program on the development of young children in low- and low-middle-income countries who are at risk for neurodevelopmental disability because of birth asphyxia. A group of children without perinatal complica...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2431-10-27
更新日期:2010-04-30 00:00:00
abstract:BACKGROUND:Autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by UMOD gene mutation (ADTKD-UMOD) is rare in children, characterized by hyperuricemia, gout, and progressive chronic kidney disease. It usually leads to end-stage renal failure at fiftieth decades. Here, we report a 3-year-old Chinese boy i...
journal_title:BMC pediatrics
pub_type: 杂志文章,评审
doi:10.1186/s12887-019-1522-7
更新日期:2019-05-08 00:00:00
abstract:BACKGROUND:Insufficient elastin synthesis leads to vascular complications and arterial hypertension in children with Williams-Beuren syndrome. Restoring sufficient quantity of elastin should then result in prevention or inhibition of vascular malformations and improvement in arterial blood pressure. METHODS:The aim of...
journal_title:BMC pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12887-019-1544-1
更新日期:2019-05-28 00:00:00
abstract:BACKGROUND:Childhood is an important period for developing maturity in thinking. Accumulating evidence shows the association between physical activity and cognitive function. Although both the intelligence quotient and emotional quotient have been reported to be associated with physical activity, there is a limited amo...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-2017-2
更新日期:2020-03-12 00:00:00
abstract:BACKGROUND:Children with sickle cell anemia (SCA) are highly susceptible to stroke and other manifestations of pediatric cerebral vasculopathy. Detailed evaluations in sub-Saharan Africa are limited. METHODS:We aimed to establish the frequency and types of pediatric brain injury in a cross-sectional study at a large S...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1758-2
更新日期:2019-10-25 00:00:00
abstract:BACKGROUND:Early diagnosis and treatment are improving significantly the quality of life of patients with cystic fibrosis (CF). This recessive disease is caused by a great variability of mutations in the CF transmembrane conductance (CFTR) gene, whose spectrum and frequency can be different across populations. METHODS...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1903-y
更新日期:2020-01-03 00:00:00
abstract:BACKGROUND:As many preschoolers are not able to cooperate with health-related invasive procedures, sedation can help with the child's comfort and allow the intervention to be done. It is scarcely known how parents affect children's behavior during dental treatment under conscious sedation. The aim of this exploratory s...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-016-0743-2
更新日期:2016-12-03 00:00:00
abstract:BACKGROUND:Children and adolescents with cerebral palsy suffer from higher levels of pain than their peers without disability. The aim of this study was to explore the impact of pain on health-related quality of life and motor function in individuals with cerebral palsy as reported by health professionals. METHODS:Cro...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-14-192
更新日期:2014-07-27 00:00:00
abstract:BACKGROUND:Autism Spectrum Disorder (ASD) is a significant childhood disorder and has a growing prevalence rate across the world. It has been identified in children from a wide range of racial groups, ethnicities and socio-economic groups, making it a globally relevant disorder. However, a lack of research on ASD in Af...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-016-0721-8
更新日期:2016-11-14 00:00:00
abstract:BACKGROUND:Infants born at extreme prematurity are at high risk of developmental disability. A major risk factor for disability is having a low level of thyroid hormone described as hypothyroxinaemia, which is recognised to be a frequent phenomenon in these infants. Derangements of critical thyroid function during the ...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1186/1471-2431-8-26
更新日期:2008-06-30 00:00:00
abstract:BACKGROUND:Passive smoking unfavorably affects pregnancy, child birth and child health. Passive smoking associates with still-birth, premature birth as well as acute respiratory infection, asthma, disorder in red blood cell metabolism in children. This study examined the effects of passive smoking on anemia in young ch...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-7-16
更新日期:2007-04-10 00:00:00
abstract:BACKGROUND:Adolescent communication with parents is paramount to reduce sexual health problems. Currently, there is a shortage of information on adolescent-parent communication in Ethiopia in general and study area in particular. Thus, this study is intended to determine adolescent-parent communication on sexual and re...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/s12887-018-1388-0
更新日期:2019-01-07 00:00:00
abstract:BACKGROUND:The "Staying Healthy in Child Care" Australian guidelines provide for illness and disease exclusions and encourage vaccination of staff in child care settings, however these requirements are not subject to accreditation and licensing, and their level of implementation is unknown. This study aimed to describe...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-12-98
更新日期:2012-07-13 00:00:00
abstract:BACKGROUND:Serious thromboembolic events connected with rFVIIa therapy in hemophilia patients are rare. Only three cases are reported in children, all of them with hemophilia A. CASE PRESENTATION:We present unique case of patient with hemophilia B and high titer inhibitors to coagulation FIX, who developed severe rena...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-014-0315-2
更新日期:2014-12-17 00:00:00
abstract:BACKGROUND:Increased survival of extremely low birth infants due to advances in antenatal and neonatal care has resulted in a population of infants at high risk of developing retinopathy of prematurity (ROP). Therapeutic interventions include the use of antenatal and postnatal steroids however, their effects on the sev...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-5-18
更新日期:2005-06-28 00:00:00