Renal thromboembolism during treatment with recombinant activated factor VII (rFVIIa) in a child with hemophilia B with factor IX inhibitors.

Abstract:

BACKGROUND:Serious thromboembolic events connected with rFVIIa therapy in hemophilia patients are rare. Only three cases are reported in children, all of them with hemophilia A. CASE PRESENTATION:We present unique case of patient with hemophilia B and high titer inhibitors to coagulation FIX, who developed severe renal damage due to thromboembolic event during rFVIIa therapy, associated with unsuspected renovascular anomalies. CONCLUSION:Caution is necessary if hematuria B requires administration of rFVIIa. US color doppler renal imaging before and after drug administration should be sufficient as an early warning.

journal_name

BMC Pediatr

journal_title

BMC pediatrics

authors

Milošević D,Bilić E,Batinić D,Poropat M,Štern-Padovan R,Galić S,Turudić D

doi

10.1186/s12887-014-0315-2

subject

Has Abstract

pub_date

2014-12-17 00:00:00

pages

315

issn

1471-2431

pii

s12887-014-0315-2

journal_volume

14

pub_type

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