Abstract:
BACKGROUND:Considerable heterogeneity has been observed in the selection and reporting of disease-specific pediatric outcome measures in randomized controlled trials (RCTs). This makes interpretation of results and comparison across trials challenging. Outcome measures in pediatric anaphylaxis trials have never previously been systematically assessed. This systematic review (SR) identified and assessed outcome measures used in RCTs of anaphylaxis treatment in children. As a secondary objective, this SR assessed the evidence for current treatment modalities for anaphylaxis in the pediatric population. METHODS:We searched MEDLINE, EMBASE, The Cochrane Library, Cochrane Central Register of Controlled Trials (CENTRAL), and CINAHL from 2001 until December 2012. We also searched websites listing ongoing trials. We included randomized and controlled trials of anaphylaxis treatment in patients 0-18 years of age. Two authors independently assessed articles for inclusion. RESULTS:No published studies fulfilled the inclusion criteria. CONCLUSIONS:There is an alarming absence of RCTs evaluating the treatments for anaphylaxis in children. High quality studies are needed and are possible to design, despite the severe and acute nature of this condition. Consensus about the selection and validation of appropriate outcome measures will enhance the quality of research and improve the care of children with anaphylaxis. TRIAL REGISTRATION:CRD42012002685.
journal_name
BMC Pediatrjournal_title
BMC pediatricsauthors
Rubin T,Clayton J,Adams D,Jou H,Vohra Sdoi
10.1186/1471-2431-14-158subject
Has Abstractpub_date
2014-06-20 00:00:00pages
158issn
1471-2431pii
1471-2431-14-158journal_volume
14pub_type
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