Abstract:
BACKGROUND:To explore the relationship between the pathological changes of the colon, terminal ileum, lung, liver and kidney, and the changes of Bax, PCNA and PAF in a rat model of NEC. METHODS:One hundred and forty neonatal SD rats were randomly divided into NEC group and control group (70 in each group). NEC group was given hypoxia, cold stimulation and artificial feeding twice a day for 3 consecutive days. The control group was only fed normally. After modeling, From the 1st day to the 7th day, 10 rats were sampled in each group for pathological examination of colon, terminal ileum, lung, liver and kidney tissue. The levels of Bax, PCNA and PAF were investigated by immunohistochemistry. RESULTS:Compared with the normal group, in the NEC group, on the 1st day, the colon, terminal ileum, lung, liver and kidney showed inflammatory damage. On the 5th day, the inflammatory injury was reduced. The inflammation disappeared on the 7th day. There were differences in the time of apoptosis in the intestine. In the intestine, the proliferation of PCNA was weak at first and then strong. Bax in liver and kidney showed marked apoptosis and apoptosis time increased in the lung. The expression of PCNA increased in lung, liver and kidney, and the expression of PAF increased in lung and liver. CONCLUSIONS:NEC can lead to secondary injury of different degrees in colon, terminal ileum, lung, liver and kidney, and the degree and time of injury and repair were different. In general, organ repair played a leading role on the 4th day after modeling.
journal_name
BMC Pediatrjournal_title
BMC pediatricsauthors
Wang FS,Yu ML,Li WZ,Hong K,Xu CB,Wang GHdoi
10.1186/s12887-020-02304-5subject
Has Abstractpub_date
2020-09-02 00:00:00pages
418issue
1issn
1471-2431pii
10.1186/s12887-020-02304-5journal_volume
20pub_type
杂志文章相关文献
BMC Pediatrics文献大全abstract:BACKGROUND:Intestinal parasitic infection is diversified illness and diseases caused millions morbidity among under-five children lives in developing countries particularly vulnerable rural communities. Deworming coverage in such community is low. The aim of this study was to determine the prevalence and associated ris...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1731-0
更新日期:2019-10-27 00:00:00
abstract:BACKGROUND:Bazett formula is frequently used in paediatric screening for the long QT syndrome (LQTS) and proposals exist that using standing rather than supine electrocardiograms (ECG) improves the sensitivity of LQTS diagnosis. Nevertheless, compared to adults, children have higher heart rates (especially during postu...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02460-8
更新日期:2020-12-14 00:00:00
abstract:BACKGROUND:The Internet may serve as a suitable environment for discriminated adolescents as they may consider the online space as the place where they have possibility to build social ties they are missing in their offline life or manage their self-presentation. Therefore, our aim was to explore the association betwee...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02241-3
更新日期:2020-08-25 00:00:00
abstract:BACKGROUND:Hydroxyurea (HU) is recommended as standard practice for youth with sickle cell disease (SCD). Yet, despite its efficacy, HU adherence in adolescents and young adults is often poor. Poor medication adherence increases disease burden, healthcare cost and widens health disparities. Adolescence is a critical ti...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1746-6
更新日期:2019-10-15 00:00:00
abstract:BACKGROUND:Type 1 diabetes (T1D) is caused by immune-mediated destruction of the β-cells. After initiation of insulin therapy many patients experience a period of improved residual β-cell function leading to partial disease remission. Cytokines are important immune-modulatory molecules and contribute to β-cell damage i...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02339-8
更新日期:2020-09-23 00:00:00
abstract:BACKGROUND:While therapy services may start in the Neonatal Intensive Care Unit (NICU) there is often a gap in therapy after discharge. Supporting Play Exploration and Early Development Intervention (SPEEDI) supports parents, helping them build capacity to provide developmentally supportive opportunities starting in th...
journal_title:BMC pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12887-018-1011-4
更新日期:2018-02-09 00:00:00
abstract:BACKGROUND:Although numerous evidence-based and feasible interventions are available to treat pain from childhood vaccine injections, evidence indicates that children are not benefitting from this knowledge. Unrelieved vaccination pain puts children at risk for significant long-term harms including the development of n...
journal_title:BMC pediatrics
pub_type: 临床试验,杂志文章
doi:10.1186/1471-2431-13-23
更新日期:2013-02-08 00:00:00
abstract:BACKGROUND:The early introduction of solid foods before 4 months of age has been associated with an increased risk of diarrhoea in infancy and a greater risk of wheeze and increased percentage body fat and weight in childhood. The purpose of this study was to identify the level of compliance with national recommendatio...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/1471-2431-9-60
更新日期:2009-09-22 00:00:00
abstract:BACKGROUND:Despite the need to identify the causes of disparities in childhood obesity, the existing epidemiologic studies of early life risk factors have several limitations. We report on the construction of the Linked CENTURY database, incorporating CENTURY (Collecting Electronic Nutrition Trajectory Data Using Recor...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-016-0567-0
更新日期:2016-03-09 00:00:00
abstract:BACKGROUND:Severe dehydration is generally believed to be a cause of significant hyperbilirubinemia in newborn babies. This study aimed to analyze the weight loss of healthy term newborn infants at 24, 48 and 72 hours after birth to predict significant hyperbilirubinemia at 72 hours. METHODS:From January 2007 to Decem...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-13-145
更新日期:2013-09-21 00:00:00
abstract:BACKGROUND:Childhood obesity is rising in developed and developing countries, while childhood underweight is rising mainly in developing countries. Childhood underweight has been shown to increase a child's risk of rapid weight gain. Overweight and obese children are more likely to become obese adults, which increases ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1842-7
更新日期:2019-12-09 00:00:00
abstract:BACKGROUND:Quality hospital care is important in ensuring that the needs of severely ill children are met to avert child mortality. However, the quality of hospital care for children in developing countries has often been found poor. As the first step of a country road map for improving hospital care for children, we a...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-12-197
更新日期:2012-12-26 00:00:00
abstract:BACKGROUND:Infants born at 34(+0) to 36(+6) weeks gestation are defined as 'late preterm' infants. It is not clear whether these babies can be managed on the postnatal ward (PNW) or routinely need to be admitted to the neonatal unit after birth. AIM:To conduct a national survey of admission practice for late preterm a...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-14-150
更新日期:2014-06-17 00:00:00
abstract:BACKGROUND:Several maternal health determinants during the first period of life of the child, as feeding practice, smoking habit and socio-economic level, are involved in early childhood health problems, as caries development. The potential associations among early childhood caries, feeding practices, maternal and envi...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-14-45
更新日期:2014-02-15 00:00:00
abstract:BACKGROUND:Poisoning in toddlers and infants is almost always unintentional due to their exploratory behavior, which is different from adults. The prevalence and background of childhood poisoning in Qatar is still unknown. The aim of this study is to explore the extent of childhood poisoning in Qatar and, specifically,...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-015-0423-7
更新日期:2015-08-28 00:00:00
abstract:BACKGROUND:Rhabdomyolysis is a potentially life-threatening syndrome that can develop from a variety of causes. The aim of the work is to analyze the clinical spectrum and to evaluate the prevalence of various etiologies in children, who present to the emergency department (ED) with rhabdomyolysis. METHODS:During a 6-...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-13-134
更新日期:2013-09-03 00:00:00
abstract:BACKGROUND:Transgender (TG) individuals experience discordance between their sex at birth and their gender identity. To better understand the health care needs and characteristics of TG youth that contribute to resilience, we conducted a qualitative study with clinical and non-clinical providers. METHODS:In-depth inte...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-015-0505-6
更新日期:2015-11-18 00:00:00
abstract:BACKGROUND:Establishing healthy physical activity (PA) behaviours in early childhood is important for future PA behaviours. Parents play a central role in young children's PA. However, there is currently little research on parenting interventions to increase child PA. This study was formative work to inform the content...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-12-180
更新日期:2012-11-20 00:00:00
abstract:BACKGROUND:Subacute Sclerosing Panencephalitis (SSPE) is so rare in developed countries with measles immunization programs that national active surveillance is now needed to capture sufficient number of cases for meaningful analysis of data. Through the Canadian Paediatric Surveillance Program (CPSP), the SSPE study wa...
journal_title:BMC pediatrics
pub_type: 杂志文章,评审
doi:10.1186/1471-2431-5-47
更新日期:2005-12-15 00:00:00
abstract:BACKGROUND:For treatment of Graf class IIb dysplastic hips at walking onset a treatment concept with abduction splints allowing patterns as walking and crawling under constant abduction control was investigated. However, as the splint still incapacitates child movements the research question remains whether the physiol...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-5-17
更新日期:2005-06-15 00:00:00
abstract:BACKGROUND:Hypertension is an important health problem in China and raised blood pressure in children may lead to future hypertension. Accordingly we aimed to provide a reference blood pressure table for age, gender and height in Chinese children. METHODS:A reference sample of subjects was drawn from the Chinese Healt...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-13-195
更新日期:2013-11-25 00:00:00
abstract:BACKGROUND:The transport of critically ill patients to children's hospitals is essential to current practice. The AAP Section on Transport Medicine has raised concerns about future leadership in the field as trainees receive less exposure to transport medicine. This study identifies the priorities of pediatric subspeci...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-017-0780-5
更新日期:2017-01-13 00:00:00
abstract:BACKGROUND:Systemic fungal infection (SFI) is one of leading causes of morbidity and mortality in very low birth weight (VLBW) preterm infants. Because early diagnosis of SFI is challenging due to nonspecific manifestations, prophylaxis becomes crucial. This study aimed to assess effectiveness of oral nystatin as an an...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-020-02074-0
更新日期:2020-04-17 00:00:00
abstract:BACKGROUND:There is increasing recognition of the value of "real-world evidence" in evaluating health care services. Registry-based, observational studies conducted in clinical settings represent a relevant model to achieve this directive. Starting in 2010, we undertook a longitudinal, observational study (the CANadian...
journal_title:BMC pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1186/s12887-018-1208-6
更新日期:2018-07-19 00:00:00
abstract:BACKGROUND:Acute mountain sickness (AMS) is commonly found among people traveling above 2500 m. We investigated whether the occurrence of AMS is related to differences in individual physical fitness and BMI in subjects 11-13 years of age. METHODS:This study was conducted at Xue Mountain, Taiwan (elevation of 3886 m) b...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-015-0373-0
更新日期:2015-05-08 00:00:00
abstract:BACKGROUND:Seven years of age is a milestone for learning basic knowledge that is strongly related to attention abilities such as Alerting, Orienting, and Inhibition function, allowing for appropriate adaptation to primary school. These attention abilities are also influenced by gestational age at birth in a complex ma...
journal_title:BMC pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1186/s12887-018-1229-1
更新日期:2018-08-06 00:00:00
abstract:BACKGROUND:The purpose of this study was to determine the prevalence of high blood pressure (HBP) and associated risk factors in school children 8 to 13 years of age. METHODS:Elementary school children (n = 1,066) were examined. Associations between HBP, body mass index (BMI), gender, ethnicity, and acanthosis nigrica...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-6-32
更新日期:2006-11-16 00:00:00
abstract:BACKGROUND:Breastfeeding offers incredible health benefits to both child and mother. It is suggested by World Health Organization that an able mother should practice and maintain exclusive breastfeeding for first six months of her infant's life. The objective of this study was to determine the prevalence and factors as...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-018-1076-0
更新日期:2018-03-02 00:00:00
abstract:BACKGROUND:The objective of this study was to document the clinical, laboratory and genetic features of galactosemia in patients from the Cape Town metropolitan region. METHODS:Diagnoses were based on thin layer chromatography for galactosuria/galactosemia and assays of erythrocyte galactose-1-phosphate uridyltransfer...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/1471-2431-2-7
更新日期:2002-09-02 00:00:00
abstract:BACKGROUND:Newborn screening (NBS) for cystic fibrosis (CF) not only identifies infants with a diagnosis of CF, but also those with an uncertain diagnosis of cystic fibrosis (CF), i.e. CF transmembrane conductance regulator (CFTR)-related metabolic syndrome (CRMS) or CF screen positive inconclusive diagnosis (CFSPID). ...
journal_title:BMC pediatrics
pub_type: 杂志文章
doi:10.1186/s12887-019-1756-4
更新日期:2019-10-22 00:00:00