Monte Carlo dosimetry for targeted irradiation of individual cells using a microbeam facility.

Abstract:

:Microbeam facilities provide a unique opportunity to investigate the effects of ionising radiation on living biological cells with a precise control of the delivered dose. This paper describes dosimetry calculations performed at the single-cell level in the microbeam irradiation facility available at the Centre d'Etudes Nucléaires de Bordeaux-Gradignan in France, using the object-oriented Geant4 Monte Carlo simulation toolkit. The cell geometry model is based on high-resolution three-dimensional voxelised phantoms of a human keratinocyte (HaCaT) cell line. Such phantoms are built from confocal microscopy imaging and from ion beam chemical elemental analysis. Results are presented for single-cell irradiation with 3 MeV incident alpha particles.

journal_name

Radiat Prot Dosimetry

authors

Incerti S,Seznec H,Simon M,Barberet P,Habchi C,Moretto P

doi

10.1093/rpd/ncp003

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

2-11

issue

1

eissn

0144-8420

issn

1742-3406

pii

ncp003

journal_volume

133

pub_type

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