Abstract:
:Ionising radiation exposure of cells might induce the perturbation of cell functions and, in particular, the activation or inhibition of several important pathways. This perturbation can cause the deregulation of both intra- and extra-cellular signalling cascades (such as the inflammatory pathway) and alter not only the behaviour of directly exposed cells but also the neighbouring non-irradiated ones, through the so-called bystander effect. The aim of the present work was to investigate the complex nonlinear interactions between the inflammatory pathway and other strictly interlaced signalling pathways, such as Erk1/2 and Akt/PKB, focusing on the radiation-induced perturbation of such pathways in the dose range of 0-2 Gy. The results show how radiation affects these interconnected pathways and how confounding factors, such as the change of culture medium, can hide radiation-induced perturbations.
journal_name
Radiat Prot Dosimetryjournal_title
Radiation protection dosimetryauthors
Babini G,Ugolini M,Morini J,Baiocco G,Mariotti L,de Fatis PT,Liotta M,Ottolenghi Adoi
10.1093/rpd/ncv132subject
Has Abstractpub_date
2015-09-01 00:00:00pages
157-60issue
1-4eissn
0144-8420issn
1742-3406pii
ncv132journal_volume
166pub_type
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