Investigation of radiation-induced multilayered signalling response of the inflammatory pathway.

Abstract:

:Ionising radiation exposure of cells might induce the perturbation of cell functions and, in particular, the activation or inhibition of several important pathways. This perturbation can cause the deregulation of both intra- and extra-cellular signalling cascades (such as the inflammatory pathway) and alter not only the behaviour of directly exposed cells but also the neighbouring non-irradiated ones, through the so-called bystander effect. The aim of the present work was to investigate the complex nonlinear interactions between the inflammatory pathway and other strictly interlaced signalling pathways, such as Erk1/2 and Akt/PKB, focusing on the radiation-induced perturbation of such pathways in the dose range of 0-2 Gy. The results show how radiation affects these interconnected pathways and how confounding factors, such as the change of culture medium, can hide radiation-induced perturbations.

journal_name

Radiat Prot Dosimetry

authors

Babini G,Ugolini M,Morini J,Baiocco G,Mariotti L,de Fatis PT,Liotta M,Ottolenghi A

doi

10.1093/rpd/ncv132

subject

Has Abstract

pub_date

2015-09-01 00:00:00

pages

157-60

issue

1-4

eissn

0144-8420

issn

1742-3406

pii

ncv132

journal_volume

166

pub_type

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