Abstract：
OBJECTIVE:The purpose of this study is to verify the usefulness of the rabbit model for disc degeneration study. MATERIALS:The L1-L2, L2-L3, L3-L4, or L4-L5 lumbar intervertebral disc (IVD) of 9 mature male New Zealand White rabbits were injured by inserting a 16-gauge needle to a depth of 5 mm in the left anterolateral annulus fibrosus while leaving L5-L6 IVD uninjured. Three other rabbits also received intradiscal injections of rabbit disc cells transfected with adenovirus and bone morphogenetic protein-2 (ad-BMP-2) at L4-L5 in addition to injury by 16-gauge needle at the L1-L2 level. Using digitized radiographs, measurements of IVD height were made and analyzed by using the disc height index (DHI). Magnetic resonance imaging (MRI) scans of the injured discs, injected discs, and uninjured L5-L6 discs were performed at 15 weeks post surgery and compared with preoperative MRI scans. RESULTS:All twelve rabbits showed consistent results of disc degeneration within 15 weeks following annular puncture. DHIs of injured discs were significantly lower than that of the uninjured L5-L6 discs (p<0.05). The mean value of disc degeneration grade of injured discs was significantly higher than that of uninjured discs (p<0.05). The injection of disc cell transfected with ad-BMP-2 did not induce disc regeneration at 15 weeks after injection. CONCLUSION:This study showed that the injured disc had a significant change in DHI on simple lateral radiograph and disc degeneration grade on MRI scans within 15 weeks in all rabbits. Rabbit annular puncture model can be useful as a disc degeneration model in vivo.
journal_name
J Korean Neurosurg Socjournal_title
Journal of Korean Neurosurgical Societyauthors
Kong MH,Do DH,Miyazaki M,Wei F,Yoon SH,Wang JCdoi
10.3340/jkns.2008.44.5.327subject
Has Abstractpub_date
2008-11-01 00:00:00pages
327-33issue
5eissn
2005-3711issn
1598-7876journal_volume
44pub_type
杂志文章abstract：OBJECTIVE:Clinical features of pituitary hemorrhage vary from asymptomatic to catastrophic. The purpose of this study was to evaluate the factors related to severity of hemorrhage of pituitary adenoma. METHODS:Pituitary hemorrhage was noted in 32 of 88 patients who underwent operations between January 2000 and Decembe...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2009.46.1.23
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:To compare the clinical outcomes and biomechanical effects of total disc replacement (TDR) and posterior cervical foraminotomy (PCF) and to propose relative inclusion criteria. METHODS:Thirty-five patients who underwent surgery between 2006 and 2008 were included. All patients had single-level disease and on...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2015.0506.004
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:The objectives of the present study were to characterize the natural course of initially non-operated traumatic acute subdural hematoma (ASDH) and to identify the risk factors of hematoma progression. METHODS:Retrospective analysis was performed using sequential computed tomography (CT) images maintained in ...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2013.54.3.211
更新日期：2013-09-01 00:00:00
abstract：OBJECTIVE:The purpose of this study is to evaluate neuroprotective effect of sacral neuromodulation in rat spinal cord injury (SCI) model in the histological and functional aspects. METHODS:Twenty-one female Sprague Dawley rats were randomly divided into 3 groups : the normal control group (CTL, n=7), the SCI with sha...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2012.52.6.509
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:Posture-induced radial neuropathy, known as Saturday night palsy, occurs because of compression of the radial nerve. The clinical symptoms of radial neuropathy are similar to stroke or a herniated cervical disk, which makes it difficult to diagnose and sometimes leads to inappropriate evaluations. The purpose...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2014.55.3.148
更新日期：2014-03-01 00:00:00
abstract：:Surgical treatment of the degenerative disc disease has evolved from traditional open spine surgery to minimally invasive spine surgery including endoscopic spine surgery. Constant improvement in the imaging modality especially with introduction of the magnetic resonance imaging, it is possible to identify culprit deg...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章,评审
doi：10.3340/jkns.2017.0203.004
更新日期：2017-09-01 00:00:00
abstract：:The authors present a case of multiple intracranial calcifications after the procedure of external ventricular drain placement in a 50-year-old man with pericallosal artery aneurysm. We believe that calcifications formed dust that had fallen into the track during the external ventricular drain procedure. The clinical ...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2010.47.2.158
更新日期：2010-02-01 00:00:00
abstract：:We report a case of infantile fibrosarcoma in an 8-month-old boy manifested as a right-sided lower leg mass. Repeated local recurrence and distant metastasis were noted during the following three-year period. Whole body fluoro-deoxyglucose positron emission tomography scan revealed an asymptomatic metastasis involving...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2013.54.6.528
更新日期：2013-12-01 00:00:00
abstract：:Chordoid glioma of the third ventricle is a rare and challenging tumor to surgery because of its unique anatomical location and its close juxtaposition to the neurovascular structures and hypothalamus. The authors report a case of chordoid glioma of the third ventricle in a 43-year-old woman, who presented with headac...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2016.59.6.643
更新日期：2016-11-01 00:00:00
abstract：:To introduce a new device for catheter placement of an external ventricular drain (EVD) of cerebrospinal fluid (CSF). This device was composed of three portions, T-shaped main body, rectangular pillar having a central hole to insert a catheter and an arm pointing the tragus. The main body has a role to direct a ventri...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2016.59.3.322
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:The purpose of this study is to identify the factors affecting the failure of trials (<50% pain reduction in pain for trial period) to improve success rate of spinal cord stimulation (SCS) trial. METHODS:A retrospective review of the failed trials (44 patients, 36.1%) among the patients (n=122) who underwent...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2008.43.2.85
更新日期：2008-02-01 00:00:00
abstract：OBJECTIVE:The inter-rater reliability of the modified Knosp's classification was measured before the analysis. The clinical validity of the parasellar extension grading system was evaluated by investigating the extents of resection and complication rates among the grades in the endoscopic endonasal transsphenoidal surg...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2016.59.6.577
更新日期：2016-11-01 00:00:00
abstract：:We report a case of pedicle screw loosening treated by modified transpedicular screw augmentation technique using polymethylmethacrylate (PMMA), which used the anchoring effect of hardened PMMA. A 56-year-old man who had an L3/4/5 fusion operation 3 years ago complained of continuous low back pain after this operation...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2011.49.1.75
更新日期：2011-01-01 00:00:00
abstract：OBJECTIVE:The present study aims to investigate 1) the risk factors for hydrocephalus and subdural hygroma (SDG) occurring after decompressive craniectomy (DC), and 2) the association between the type of SDG and hydrocephalus. METHODS:We retrospectively reviewed the clinical and radiological features of 92 patients wh...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2015.58.3.254
更新日期：2015-09-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to evaluate whether (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) can be used to assess the therapeutic response of brain abscess. METHODS:A study was conducted on 10 consecutive patients with brain abscess. Magnetic resonance imaging (MRI) with diffuse-weighte...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2011.49.5.278
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:A groove technique for securing an electrode connector was described as an alternative surgical technique in deep brain stimulation (DBS) surgery to avoid electrode connector-related complications, such as skin erosion, infection, and migration. METHODS:We retrospectively reviewed 109 patients undergoing one...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2014.56.2.130
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:Perfusion computed tomography (PCT) has the ability to measure quantitative value and produce maps of mean transit time (MTT), cerebral blood flow (CBF), and cerebral blood volume (CBV). We assessed cerebral hemodynamics by using these parameters and acetazolamide (ACZ) challenge for pre- and post-procedural ...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2013.54.4.280
更新日期：2013-10-01 00:00:00
abstract：OBJECTIVE:We retrospectively evaluated the survival outcome of patients with brain metastasis from hepatocellular carcinoma (HCC). METHODS:Between 1991 and 2007, a total of 20 patients were diagnosed as having brain metastasis from HCC. The mean age of the patients was 55 +/- 13 years, and 17 (85.0%) were men. Sevente...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2010.47.5.325
更新日期：2010-05-01 00:00:00
abstract：:Pleomorphic xanthoastrocytoma (PXA) has been considered as a low grade tumor of adolescents and young adults. Although this tumor often shows cystic component, the hemorrhage within the cyst is extremely rare. The authors report a rare case of cystic PXA with a hemorrhage within the cyst and the mural nodule in the le...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2007.42.5.410
更新日期：2007-11-01 00:00:00
abstract：OBJECTIVE:According to the recent development of minimally invasive spinal surgery, direct lumbar interbody fusion (DLIF) was introduced as an effective option to treat lumbar degenerative diseases. However, comprehensive results of DLIF have not been reported in Korea yet. The object of this study is to summarize radi...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2014.55.5.248
更新日期：2014-05-01 00:00:00
abstract：:We report two rare cases of spinal intraosseous schwannoma (SIS) with sustained myelopathy symptoms and provide an updated review regarding SIS in the literature. A 71-year-old man experienced right lumbocrural pain and gait disturbance accompanied with paresthesia and right leg weakness. Imaging examinations revealed...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2015.57.6.478
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVE:To examine the synergistic effects of both computer-assisted cognitive rehabilitation (CACR) and transcranial direct current stimulation (tDCS) on cognitive function in patients with stroke. METHODS:The current double-blind, sham-controlled study enrolled a total of 11 patients who were newly diagnosed with ...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2013.54.6.484
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:This study characterized the neurons in the lumbosacral cord that express phospho ERK (pERK) after distension or irritation of the bladder, and their relation to the vanilloid receptor 1 (VR1) positive primary afferents. METHODS:Mechanical distension and chemical irritation of the bladder were induced by int...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2007.42.6.462
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE:The indications and optimal surgical treatments for intracranial cysts are controversial. In the present study, we describe long-term clinical and neuroimaging results of surgically treated intracranial cysts in children. The goal of this study is to contribute to the discussion of the debate. METHODS:This s...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2012.52.4.325
更新日期：2012-10-01 00:00:00
abstract：:Intracranial extraskeletal myxoid chondrosarcoma is extremely rare, with only seven patients previously reported. We present a case report of a 21-year-old woman admitted for weakness in her right extremities and symptoms of increased intracranial pressure. Magnetic resonance imaging (MRI) revealed hydrocephalus and a...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2012.52.3.246
更新日期：2012-09-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine the efficacy of short segment fixation following postural reduction for the re-expansion and stabilization of unstable burst fractures in patients with osteoporosis. METHODS:Twenty patients underwent short segment fixation following postural reduction using a soft r...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2008.44.1.8
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:Aneurysmal rebleeding is a major cause of death and disability. The aim of this study is to investigate the incidence of rebleeding, and the factors related with patient's outcome. METHODS:During a period of 12 years, from September 1995 to August 2007, 492 consecutive patients with aneurysmal subarachnoid h...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2010.47.2.119
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to elucidate the anatomical development of physiologic suture closure processes in infants using three dimensional reconstructed computed tomography (CT). METHODS:A consecutive series of 243 infants under 12 months of age who underwent three dimensional CT were included in this ...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2012.51.1.31
更新日期：2012-01-01 00:00:00
abstract：:We report a supratentorial primitive neuroectodermal tumor (sPNET) in 17-year-old primipara in the second trimester her pregnancy. Magnetic resonance imaging revealed a left frontoparietal mass with solid and cystic component. Gross-total resection was achieved via a left frontoparietal craniotomy. It was decided to s...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2009.45.1.39
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:To investigate a diagnostic value of ultrasonography in carpal tunnel syndrome (CTS) patients and to evaluate a correlation of sonographic measurements with the degree of electrodiagnostic abnormalities and clinical severity. METHODS:Two-hundred-forty-six symptomatic hands in 135 patients and 30 asymptomatic...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2014.55.2.78
更新日期：2014-02-01 00:00:00
