Abstract：
OBJECTIVE:Perfusion computed tomography (PCT) has the ability to measure quantitative value and produce maps of mean transit time (MTT), cerebral blood flow (CBF), and cerebral blood volume (CBV). We assessed cerebral hemodynamics by using these parameters and acetazolamide (ACZ) challenge for pre- and post-procedural evaluation in patients with unilateral cerebrovascular stenotic disease. METHODS:Thirty patients underwent pre-procedural PCT with ACZ challenge, and 24 patients (80%) was conducted follow up PCT after angioplasty with same protocol. The mean MTT, CBF, and CBV were measured and compared in both middle cerebral arterial (MCA) territories before and after ACZ challenge. Hemispheric ratio and percent change after ACZ challenge were calculated before and after angioplasty. RESULTS:The mean stenosis rate was 76.6%. Significant increases in MTT (32.6%, p=0.000) and significant decreases in CBF (-14.2%, p=0.000) were found in stenotic side MCA territories. After ACZ challenge, there were significant changes in MTT (37.4%, p=0.000), CBF (-13.1%, p=0.000), and CBV (-10.5%, p=0.001) in pre-procedural perfusion study. However, no significant increases were found in MTT, or decreases in CBF and CBV in post-procedural study. There were no significant changes after ACZ challenge also. In addition, the degrees of these changes (before and after ACZ challenge) were highly correlated with the stenotic degrees in pre-procedural perfusion study. CONCLUSION:PCT with ACZ challenge appears to be a useful tool to assess the cerebral perfusion status especially in patients with unilateral symptomatic stenotic disease.
journal_name
J Korean Neurosurg Socjournal_title
Journal of Korean Neurosurgical Societyauthors
You SH,Jo SM,Kim YJ,Lee JH,Jo KD,Park WSdoi
10.3340/jkns.2013.54.4.280subject
Has Abstractpub_date
2013-10-01 00:00:00pages
280-8issue
4eissn
2005-3711issn
1598-7876journal_volume
54pub_type
杂志文章abstract：OBJECTIVE:To evaluate the feasibility and clinical and angiographic outcomes of stent-assisted embolization for complex middle cerebral artery (MCA) aneurysms. METHODS:The records of 23 consecutive patients with 24 MCA aneurysms, who underwent stent-assisted embolization of the aneurysm, were retrospectively evaluated...
journal_title：Journal of Korean Neurosurgical Society
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journal_title：Journal of Korean Neurosurgical Society
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更新日期：2013-08-01 00:00:00
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journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
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journal_title：Journal of Korean Neurosurgical Society
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更新日期：2008-09-01 00:00:00
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journal_title：Journal of Korean Neurosurgical Society
pub_type：
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更新日期：2011-02-01 00:00:00
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pub_type： 杂志文章
doi：10.3340/jkns.2018.0035
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journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章,评审
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更新日期：2017-05-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
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更新日期：2013-02-01 00:00:00
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pub_type：
doi：10.3340/jkns.2010.48.3.281
更新日期：2010-09-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2018.0018
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更新日期：2011-12-01 00:00:00
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