Abstract:
OBJECTIVE:Spinal cord injury (SCI) is a very serious health problem, usually caused by a trauma and accompanied by elevated levels of inflammation indicators. Stem cell-based therapy is promising some valuable strategies for its functional recovery. Nestinpositive progenitor and/or stem cells (SC) isolated from pancreatic islets (PI) show mesenchymal stem cell (MSC) characteristics. For this reason, we aimed to analyze the effects of rat pancreatic islet derived stem cell (rPI-SC) delivery on functional recovery, as well as the levels of inflammation factors following SCI. METHODS:rPI-SCs were isolated, cultured and their MSC characteristics were determined through flow cytometry and immunofluorescence analysis. The experimental rat population was divided into three groups : 1) laminectomy & trauma, 2) laminectomy & trauma & phosphate-buffered saline (PBS), and 3) laminectomy+trauma+SCs. Green fluorescent protein (GFP) labelled rPI-SCs were transplanted into the injured rat spinal cord. Their motilities were evaluated with Basso, Beattie and Bresnahan (BBB) Score. After 4-weeks, spinal cord sections were analyzed for GFP labeled SCs and stained for vimentin, S100β, brain derived neurotrophic factor (BDNF), 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNPase), vascular endothelial growth factor (VEGF) and proinflammatory (interleukin [IL]-6, transforming growth factor [TGF]-β, macrophage inflammatory protein [MIP]-2, myeloperoxidase [MPO]) and anti-inflammatory (IL-1 receptor antagonis) factors. RESULTS:rPI-SCs were revealed to display MSC characteristics and express neural and glial cell markers including BDNF, glial fibrillary acidic protein (GFAP), fibronectin, microtubule associated protein-2a,b (MAP2a,b), β3-tubulin and nestin as well as antiinflammatory prostaglandin E2 receptor, EP3. The BBB scores showed significant motor recovery in group 3. GFP-labelled cells were localized on the injury site. In addition, decreased proinflammatory factor levels and increased intensity of anti-inflammatory factors were determined. CONCLUSION:Transplantation of PI-SCs might be an effective strategy to improve functional recovery following spinal cord trauma.
journal_name
J Korean Neurosurg Socjournal_title
Journal of Korean Neurosurgical Societyauthors
Karaoz E,Tepekoy F,Yilmaz I,Subasi C,Kabatas Sdoi
10.3340/jkns.2018.0035subject
Has Abstractpub_date
2019-03-01 00:00:00pages
153-165issue
2eissn
2005-3711issn
1598-7876pii
jkns.2018.0035journal_volume
62pub_type
杂志文章abstract::Acute subdural hematoma (SDH) of arterial origin is rare, especially SDH associated with an arteriovenous malformation (AVM) is extremely rare. The authors report a case of acute spontaneous SDH due to rupture of a tiny cortical AVM. A 51-year-old male presented with sudden onset headache and mentality deterioration w...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2015.58.6.547
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:The objective of this study is to investigate clinical characteristics, management methods and possible causes of intracranial fusiform aneurysm. METHODS:Out of a series of 2,458 intracranial aneurysms treated surgically or endovascularly, 22 patients were identified who had discrete fusiform aneurysms. Clin...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2008.44.3.116
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abstract:OBJECTIVE:Penumbra ACE68 reperfusion catheter is a new large bore aspiration catheter used for reperfusion of large vessel occlusion. The objective of this study was to investigate the efficacy of this catheter in comparison to that of previous Penumbra catheters in patients with acute ischemic stroke related to intern...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2019.0108
更新日期:2019-09-01 00:00:00
abstract:OBJECTIVE:Although anterior cervical discectomy and fusion (ACDF) is the standard treatment for degenerative cervical disc disease, concerns regarding adjacent level degeneration and loss of motion have suggested that arthroplasty may be a better alternative. We have compared clinical and radiological results in patien...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2008.44.4.217
更新日期:2008-10-01 00:00:00
abstract::Diffuse intrinsic pontine glioma (DIPG) is a deadly paediatric brain cancer. Transient response to radiation, ineffective chemotherapeutic agents and aggressive biology result in rapid progression of symptoms and a dismal prognosis. Increased availability of tumour tissue has enabled the identification of histone gene...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章,评审
doi:10.3340/jkns.2018.0008
更新日期:2018-05-01 00:00:00
abstract::The authors present a case of isolated dural arteriovenous fistula (DAVF) in the transverse sinus, which developed six years after microvascular decompression caused by hemifacial spasm via suboccipital craniectomy. The lesion was successfully treated by transarterial embolization using Onyx. We reviewed the related r...
journal_title:Journal of Korean Neurosurgical Society
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doi:10.3340/jkns.2012.52.5.480
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:The potassium disturbance associated with thiopental continuous infusion in neurosurgical patients is well known. However, the effect of propofol continuous infusion on serum potassium levels has not been investigated extensively. METHODS:We reviewed the medical records of 60 consecutive patients who receive...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2015.57.3.197
更新日期:2015-03-01 00:00:00
abstract::Ossification of the posterior longitudinal ligament (OPLL) in the thoracic spine is rare, even in the Far East. A 45-year-old female presented with a 4-month history of progressive motor weakness in the lower extremities, numbness below the midthoracic area, and spastic gait disturbance. Neuroradiological examinations...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2010.47.1.55
更新日期:2010-01-01 00:00:00
abstract::Acute spontaneous subdural hematoma (SDH) of arterial origin is very rare. We report a case of acute spontaneous SDH that showed contrast media extravasation from cortical artery on angiograms. A 58-year-old male patient developed sudden onset headache and right hemiparesis. Brain CT scan demonstrated acute SDH at lef...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2012.51.2.91
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:Brainstem metastases are rarely operable and generally unresponsive to conventional radiation therapy or chemotherapy. Recently, Gamma Knife Radiosurgery (GKRS) was used as feasible treatment option for brainstem metastasis. The present study evaluated our experience of brainstem metastasis which was treated ...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2011.50.4.299
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to examine the efficacy and safety of microvascular decompression (MVD) for hemifacial spasm (HFS) in elderly patients. METHODS:Between 1997 and June 2008, 1,174 patients had undergone MVD for HFS at our institute. Among these, 53 patients were older than 65 years. We retrospect...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2010.47.6.442
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:General anesthesia is often preferred for endovascular coiling of intracranial aneurysm at most centers. But in the authors' hospital, it is performed under monitored anesthesia care (MAC) using dexmedetomidine. To determine the feasibility and safety of this approach, the authors reviewed our initial experie...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2014.55.4.185
更新日期:2014-04-01 00:00:00
abstract::Glioblastoma (GBM) is a disease without any definite cure. Numerous approaches have been tested in efforts to conquer this brain disease, but patients invariably experience recurrence or develop resistance to treatment. New surgical tools, carefully chosen samples, and experimental methods are enabling discoveries at ...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2019.0129
更新日期:2020-01-01 00:00:00
abstract::Alveolar soft part sarcoma (ASPS) with skull and brain metastases is extremely rare. A 53-year-old patient diagnosed as skull metastasis of ASPS visited our clinic complaining of an outgrowing scalp mass in spite of radiation therapy. Past medical history revealed that the patient had been diagnosed and treated for AS...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2012.52.1.55
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:The case fatality rate of nonlesional intracerebral hemorrhage (n-ICH) was high and not changed. Knowing the causes is important to their prevention; however, the reasons have not been studied. The aims of this study were to determine the cause of death, to improve the clinical outcomes. METHODS:We retrospec...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2014.55.1.1
更新日期:2014-01-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2013.54.4.344
更新日期:2013-10-01 00:00:00
abstract::The 5-aminolevulinic acid (5-ALA)-induced tumor fluorescence is a useful intraoperative marker for the diagnosis and the detection of various malignancies, but its use in meningioma is only reported infrequently. In meningioma, a complete resection of the tumor mass is crucial for the prevention of recurrence and post...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2012.52.6.558
更新日期:2012-12-01 00:00:00
abstract::To introduce a new device for catheter placement of an external ventricular drain (EVD) of cerebrospinal fluid (CSF). This device was composed of three portions, T-shaped main body, rectangular pillar having a central hole to insert a catheter and an arm pointing the tragus. The main body has a role to direct a ventri...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2016.59.3.322
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVE:The aim of the study is to determine the efficacy of indocyanine green (ICG) videoangiography for confirmation of vascular anastomosis patency in both extracranial-intracranial and intracranial-intracranial bypasses. METHODS:Intraoperative ICG videoangiography was used as a surgical adjunct for 56 bypasses i...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2011.50.1.23
更新日期:2011-07-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2016.59.1.6
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:Recently, regenerative therapies have been used in clinical trials (heart, cartilage, skeletal). We don't make use of these treatments to spinal cord injury (SCI) patients yet, but regenerative therapies are rising interest in recent study about SCI. Neural precursor/stem cell (NPSC) proliferation is a signif...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2016.59.5.437
更新日期:2016-09-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2010.48.4.375
更新日期:2010-10-01 00:00:00
abstract::Mucosa-associated lymphoid tissue (MALT) lymphoma is one of the most common lymphomas and accounts for about 7% of all newly diagnosed non-Hodgkin's lymphoma (NHL). The clinical course of MALT lymphoma is relatively indolent and, in the majority of cases (50%), the lymphoma arises within the stomach. Primary central n...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2012.51.6.377
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:We attempted to compare the incidence of pyogenic spondylitis (PS) and tuberculous spondylitis (TS) between 2007 and 2016. Furthermore, we investigated the patients who underwent surgery in 2016 compared to that in 2007. METHODS:We used a nationwide database managed by the Korean National Health Insurance Se...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2020.0013
更新日期:2020-11-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2008.44.1.8
更新日期:2008-01-01 00:00:00
abstract::Pleomorphic xanthoastrocytoma (PXA) has been considered as a low grade tumor of adolescents and young adults. Although this tumor often shows cystic component, the hemorrhage within the cyst is extremely rare. The authors report a rare case of cystic PXA with a hemorrhage within the cyst and the mural nodule in the le...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2007.42.5.410
更新日期:2007-11-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2014.56.2.130
更新日期:2014-08-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
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journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2010.48.6.528
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journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2012.51.3.144
更新日期:2012-03-01 00:00:00