Reduction of Inflammation and Enhancement of Motility after Pancreatic Islet Derived Stem Cell Transplantation Following Spinal Cord Injury.

Abstract:

OBJECTIVE:Spinal cord injury (SCI) is a very serious health problem, usually caused by a trauma and accompanied by elevated levels of inflammation indicators. Stem cell-based therapy is promising some valuable strategies for its functional recovery. Nestinpositive progenitor and/or stem cells (SC) isolated from pancreatic islets (PI) show mesenchymal stem cell (MSC) characteristics. For this reason, we aimed to analyze the effects of rat pancreatic islet derived stem cell (rPI-SC) delivery on functional recovery, as well as the levels of inflammation factors following SCI. METHODS:rPI-SCs were isolated, cultured and their MSC characteristics were determined through flow cytometry and immunofluorescence analysis. The experimental rat population was divided into three groups : 1) laminectomy & trauma, 2) laminectomy & trauma & phosphate-buffered saline (PBS), and 3) laminectomy+trauma+SCs. Green fluorescent protein (GFP) labelled rPI-SCs were transplanted into the injured rat spinal cord. Their motilities were evaluated with Basso, Beattie and Bresnahan (BBB) Score. After 4-weeks, spinal cord sections were analyzed for GFP labeled SCs and stained for vimentin, S100β, brain derived neurotrophic factor (BDNF), 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNPase), vascular endothelial growth factor (VEGF) and proinflammatory (interleukin [IL]-6, transforming growth factor [TGF]-β, macrophage inflammatory protein [MIP]-2, myeloperoxidase [MPO]) and anti-inflammatory (IL-1 receptor antagonis) factors. RESULTS:rPI-SCs were revealed to display MSC characteristics and express neural and glial cell markers including BDNF, glial fibrillary acidic protein (GFAP), fibronectin, microtubule associated protein-2a,b (MAP2a,b), β3-tubulin and nestin as well as antiinflammatory prostaglandin E2 receptor, EP3. The BBB scores showed significant motor recovery in group 3. GFP-labelled cells were localized on the injury site. In addition, decreased proinflammatory factor levels and increased intensity of anti-inflammatory factors were determined. CONCLUSION:Transplantation of PI-SCs might be an effective strategy to improve functional recovery following spinal cord trauma.

journal_name

J Korean Neurosurg Soc

authors

Karaoz E,Tepekoy F,Yilmaz I,Subasi C,Kabatas S

doi

10.3340/jkns.2018.0035

subject

Has Abstract

pub_date

2019-03-01 00:00:00

pages

153-165

issue

2

eissn

2005-3711

issn

1598-7876

pii

jkns.2018.0035

journal_volume

62

pub_type

杂志文章
  • Acute Spontaneous Subdural Hematoma due to Rupture of a Tiny Cortical Arteriovenous Malformation.

    abstract::Acute subdural hematoma (SDH) of arterial origin is rare, especially SDH associated with an arteriovenous malformation (AVM) is extremely rare. The authors report a case of acute spontaneous SDH due to rupture of a tiny cortical AVM. A 51-year-old male presented with sudden onset headache and mentality deterioration w...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2015.58.6.547

    authors: Choi HJ,Lee JI,Nam KH,Ko JK

    更新日期:2015-12-01 00:00:00

  • Intracranial Fusiform Aneurysms: It's Pathogenesis, Clinical Characteristics and Managements.

    abstract:OBJECTIVE:The objective of this study is to investigate clinical characteristics, management methods and possible causes of intracranial fusiform aneurysm. METHODS:Out of a series of 2,458 intracranial aneurysms treated surgically or endovascularly, 22 patients were identified who had discrete fusiform aneurysms. Clin...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2008.44.3.116

    authors: Park SH,Yim MB,Lee CY,Kim E,Son EI

    更新日期:2008-09-01 00:00:00

  • Initial Experience of ACE68 Reperfusion Catheter in Patients with Acute Ischemic Stroke Related to Internal Carotid Artery Occlusion.

    abstract:OBJECTIVE:Penumbra ACE68 reperfusion catheter is a new large bore aspiration catheter used for reperfusion of large vessel occlusion. The objective of this study was to investigate the efficacy of this catheter in comparison to that of previous Penumbra catheters in patients with acute ischemic stroke related to intern...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2019.0108

    authors: Jang HG,Park JS,Lee JM,Kwak HS

    更新日期:2019-09-01 00:00:00

  • Comparative analysis of cervical arthroplasty using mobi-c(r) and anterior cervical discectomy and fusion using the solis(r) -cage.

    abstract:OBJECTIVE:Although anterior cervical discectomy and fusion (ACDF) is the standard treatment for degenerative cervical disc disease, concerns regarding adjacent level degeneration and loss of motion have suggested that arthroplasty may be a better alternative. We have compared clinical and radiological results in patien...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2008.44.4.217

    authors: Park JH,Roh KH,Cho JY,Ra YS,Rhim SC,Noh SW

    更新日期:2008-10-01 00:00:00

  • Diffuse Intrinsic Pontine Glioma : Clinical Features, Molecular Genetics, and Novel Targeted Therapeutics.

    abstract::Diffuse intrinsic pontine glioma (DIPG) is a deadly paediatric brain cancer. Transient response to radiation, ineffective chemotherapeutic agents and aggressive biology result in rapid progression of symptoms and a dismal prognosis. Increased availability of tumour tissue has enabled the identification of histone gene...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章,评审

    doi:10.3340/jkns.2018.0008

    authors: Mathew RK,Rutka JT

    更新日期:2018-05-01 00:00:00

  • Dural arteriovenous fistula involving an isolated sinus treated using transarterial onyx embolization.

    abstract::The authors present a case of isolated dural arteriovenous fistula (DAVF) in the transverse sinus, which developed six years after microvascular decompression caused by hemifacial spasm via suboccipital craniectomy. The lesion was successfully treated by transarterial embolization using Onyx. We reviewed the related r...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2012.52.5.480

    authors: Ihn YK,Kim MJ,Shin YS,Kim BS

    更新日期:2012-11-01 00:00:00

  • The effects of propofol and thiopental continuous infusion on serum potassium disturbances in neurosurgical patients.

    abstract:OBJECTIVE:The potassium disturbance associated with thiopental continuous infusion in neurosurgical patients is well known. However, the effect of propofol continuous infusion on serum potassium levels has not been investigated extensively. METHODS:We reviewed the medical records of 60 consecutive patients who receive...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2015.57.3.197

    authors: Kim TK,Lim YJ,Ju JW,Kim JW,Park HP

    更新日期:2015-03-01 00:00:00

  • Late Occurrence of Cervicothoracic Ossification of Posterior Longitudinal Ligaments in a Surgically Treated Thoracic OPLL Patient.

    abstract::Ossification of the posterior longitudinal ligament (OPLL) in the thoracic spine is rare, even in the Far East. A 45-year-old female presented with a 4-month history of progressive motor weakness in the lower extremities, numbness below the midthoracic area, and spastic gait disturbance. Neuroradiological examinations...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2010.47.1.55

    authors: Hyun SJ,Kim JS,Hong SC

    更新日期:2010-01-01 00:00:00

  • Acute spontaneous subdural hematoma of arterial origin.

    abstract::Acute spontaneous subdural hematoma (SDH) of arterial origin is very rare. We report a case of acute spontaneous SDH that showed contrast media extravasation from cortical artery on angiograms. A 58-year-old male patient developed sudden onset headache and right hemiparesis. Brain CT scan demonstrated acute SDH at lef...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2012.51.2.91

    authors: Sung SK,Kim SH,Son DW,Lee SW

    更新日期:2012-02-01 00:00:00

  • Gamma knife radiosurgery for brainstem metastasis.

    abstract:OBJECTIVE:Brainstem metastases are rarely operable and generally unresponsive to conventional radiation therapy or chemotherapy. Recently, Gamma Knife Radiosurgery (GKRS) was used as feasible treatment option for brainstem metastasis. The present study evaluated our experience of brainstem metastasis which was treated ...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2011.50.4.299

    authors: Yoo TW,Park ES,Kwon DH,Kim CJ

    更新日期:2011-10-01 00:00:00

  • The efficacy and safety of microvascular decompression for hemifacial spasm in elderly patients.

    abstract:OBJECTIVE:The purpose of this study was to examine the efficacy and safety of microvascular decompression (MVD) for hemifacial spasm (HFS) in elderly patients. METHODS:Between 1997 and June 2008, 1,174 patients had undergone MVD for HFS at our institute. Among these, 53 patients were older than 65 years. We retrospect...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2010.47.6.442

    authors: Jeon CJ,Kong DS,Lee JA,Park K

    更新日期:2010-06-01 00:00:00

  • Usefulness of Dexmedetomidine during Intracerebral Aneurysm Coiling.

    abstract:OBJECTIVE:General anesthesia is often preferred for endovascular coiling of intracranial aneurysm at most centers. But in the authors' hospital, it is performed under monitored anesthesia care (MAC) using dexmedetomidine. To determine the feasibility and safety of this approach, the authors reviewed our initial experie...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2014.55.4.185

    authors: Lee HH,Jung YJ,Choi BY,Chang CH

    更新日期:2014-04-01 00:00:00

  • Glioblastoma Cellular Origin and the Firework Pattern of Cancer Genesis from the Subventricular Zone.

    abstract::Glioblastoma (GBM) is a disease without any definite cure. Numerous approaches have been tested in efforts to conquer this brain disease, but patients invariably experience recurrence or develop resistance to treatment. New surgical tools, carefully chosen samples, and experimental methods are enabling discoveries at ...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2019.0129

    authors: Yoon SJ,Park J,Jang DS,Kim HJ,Lee JH,Jo E,Choi RJ,Shim JK,Moon JH,Kim EH,Chang JH,Lee JH,Kang SG

    更新日期:2020-01-01 00:00:00

  • Alveolar soft part sarcoma metastasized to both the skull and the brain.

    abstract::Alveolar soft part sarcoma (ASPS) with skull and brain metastases is extremely rare. A 53-year-old patient diagnosed as skull metastasis of ASPS visited our clinic complaining of an outgrowing scalp mass in spite of radiation therapy. Past medical history revealed that the patient had been diagnosed and treated for AS...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2012.52.1.55

    authors: Shin TH,Jung YJ,Kim OL,Kim MS

    更新日期:2012-07-01 00:00:00

  • Mortality and real cause of death from the nonlesional intracerebral hemorrhage.

    abstract:OBJECTIVE:The case fatality rate of nonlesional intracerebral hemorrhage (n-ICH) was high and not changed. Knowing the causes is important to their prevention; however, the reasons have not been studied. The aims of this study were to determine the cause of death, to improve the clinical outcomes. METHODS:We retrospec...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2014.55.1.1

    authors: Kim KD,Chang CH,Choi BY,Jung YJ

    更新日期:2014-01-01 00:00:00

  • Delayed Retroperitoneal Hemorrhage due to Lumbar Artery Pseudoaneurysm after Lumbar Posterolateral Fusion.

    abstract::A 55-year-old female patient presented with lower back pain and neurogenic intermittent claudication and underwent L3-L4 posterolateral fusion. To prepare the bone fusion bed, the transverse process of L3 and L4 was decorticated with a drill. On the 9th post-operative day, the patient complained of a sudden onset of s...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2013.54.4.344

    authors: Oh YM,Choi HY,Eun JP

    更新日期:2013-10-01 00:00:00

  • Experience with 5-aminolevulinic Acid in fluorescence-guided resection of a deep sylvian meningioma.

    abstract::The 5-aminolevulinic acid (5-ALA)-induced tumor fluorescence is a useful intraoperative marker for the diagnosis and the detection of various malignancies, but its use in meningioma is only reported infrequently. In meningioma, a complete resection of the tumor mass is crucial for the prevention of recurrence and post...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2012.52.6.558

    authors: Chae MP,Song SW,Park SH,Park CK

    更新日期:2012-12-01 00:00:00

  • Device for Catheter Placement of External Ventricular Drain.

    abstract::To introduce a new device for catheter placement of an external ventricular drain (EVD) of cerebrospinal fluid (CSF). This device was composed of three portions, T-shaped main body, rectangular pillar having a central hole to insert a catheter and an arm pointing the tragus. The main body has a role to direct a ventri...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2016.59.3.322

    authors: Ann JM,Bae HG,Oh JS,Yoon SM

    更新日期:2016-05-01 00:00:00

  • Indocyanine green videoangiography for confirmation of bypass graft patency.

    abstract:OBJECTIVE:The aim of the study is to determine the efficacy of indocyanine green (ICG) videoangiography for confirmation of vascular anastomosis patency in both extracranial-intracranial and intracranial-intracranial bypasses. METHODS:Intraoperative ICG videoangiography was used as a surgical adjunct for 56 bypasses i...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2011.50.1.23

    authors: Schuette AJ,Dannenbaum MJ,Cawley CM,Barrow DL

    更新日期:2011-07-01 00:00:00

  • Predictor and Prognosis of Procedural Rupture during Coil Embolization for Unruptured Intracranial Aneurysm.

    abstract:OBJECTIVE:The objectives of this study was to determine the incidence and outcomes of procedural rupture (PR) during coil embolization of unruptured intracranial aneurysm (UIA) and to explore potential risk factors. METHODS:This retrospective study evaluated 1038 patients treated with coil embolization between January...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2016.59.1.6

    authors: Lee KM,Jo KI,Jeon P,Kim KH,Kim JS,Hong SC

    更新日期:2016-01-01 00:00:00

  • Neural Growth Factor Stimulates Proliferation of Spinal Cord Derived-Neural Precursor/Stem Cells.

    abstract:OBJECTIVE:Recently, regenerative therapies have been used in clinical trials (heart, cartilage, skeletal). We don't make use of these treatments to spinal cord injury (SCI) patients yet, but regenerative therapies are rising interest in recent study about SCI. Neural precursor/stem cell (NPSC) proliferation is a signif...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2016.59.5.437

    authors: Han Y,Kim KT

    更新日期:2016-09-01 00:00:00

  • Chiari 1.5 malformation : an advanced form of Chiari I malformation.

    abstract::The Chiari 1.5 malformation is defined as a tonsillar herniation within a Chiari I malformation with additional caudal descent of the brainstem through the foramen magnum. We describe a patient with Chiari I malformation who evolved to Chiari 1.5 malformation during longitudinal follow-up. A 15-year-old girl presented...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2010.48.4.375

    authors: Kim IK,Wang KC,Kim IO,Cho BK

    更新日期:2010-10-01 00:00:00

  • Gastric mucosa-associated lymphoid tissue lymphoma followed by primary central nervous system lymphoma.

    abstract::Mucosa-associated lymphoid tissue (MALT) lymphoma is one of the most common lymphomas and accounts for about 7% of all newly diagnosed non-Hodgkin's lymphoma (NHL). The clinical course of MALT lymphoma is relatively indolent and, in the majority of cases (50%), the lymphoma arises within the stomach. Primary central n...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2012.51.6.377

    authors: Eom KS,Park MR,Choi KH,Kim TY

    更新日期:2012-06-01 00:00:00

  • Change of Pyogenic and Tuberculous Spondylitis between 2007 and 2016 Year : A Nationwide Study.

    abstract:OBJECTIVE:We attempted to compare the incidence of pyogenic spondylitis (PS) and tuberculous spondylitis (TS) between 2007 and 2016. Furthermore, we investigated the patients who underwent surgery in 2016 compared to that in 2007. METHODS:We used a nationwide database managed by the Korean National Health Insurance Se...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2020.0013

    authors: Kim YJ,Hong JB,Kim YS,Yi J,Choi JM,Sohn S

    更新日期:2020-11-01 00:00:00

  • Bone cement augmentation of short segment fixation for unstable burst fracture in severe osteoporosis.

    abstract:OBJECTIVE:The purpose of this study was to determine the efficacy of short segment fixation following postural reduction for the re-expansion and stabilization of unstable burst fractures in patients with osteoporosis. METHODS:Twenty patients underwent short segment fixation following postural reduction using a soft r...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2008.44.1.8

    authors: Kim HS,Park SK,Joy H,Ryu JK,Kim SW,Ju CI

    更新日期:2008-01-01 00:00:00

  • Pleomorphic xanthoastrocytoma with an intracystic hemorrhage : a case report and literature review.

    abstract::Pleomorphic xanthoastrocytoma (PXA) has been considered as a low grade tumor of adolescents and young adults. Although this tumor often shows cystic component, the hemorrhage within the cyst is extremely rare. The authors report a rare case of cystic PXA with a hemorrhage within the cyst and the mural nodule in the le...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2007.42.5.410

    authors: Lee DK,Cho KT,Im SH,Hong SK

    更新日期:2007-11-01 00:00:00

  • A groove technique for securing an electrode connector on the cranial bone: case analysis of efficacy.

    abstract:OBJECTIVE:A groove technique for securing an electrode connector was described as an alternative surgical technique in deep brain stimulation (DBS) surgery to avoid electrode connector-related complications, such as skin erosion, infection, and migration. METHODS:We retrospectively reviewed 109 patients undergoing one...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2014.56.2.130

    authors: Lee SW,Lee MK,Seo I,Kim HS,Kim JH,Kim YS

    更新日期:2014-08-01 00:00:00

  • Anterior lumbar interbody fusion for the treatment of postoperative spondylodiscitis.

    abstract:OBJECTIVE:To analyze the clinical courses and outcomes after anterior lumbar interbody fusion (ALIF) for the treatment of postoperative spondylodiscitis. METHODS:A total of 13 consecutive patients with postoperative spondylodiscitis treated with ALIF at our institute from January, 1994 to August, 2013 were included (9...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type: 杂志文章

    doi:10.3340/jkns.2014.56.4.310

    authors: Kim SH,Kang MS,Chin DK,Kim KS,Cho YE,Kuh SU

    更新日期:2014-10-01 00:00:00

  • Fusiform aneurysm presenting with cervical radiculopathy in ehlers-danlos syndrome.

    abstract::Ehlers-Danlos syndrome (EDS) type IV is characterized by its clinical manifestations, which are easy bruising, thin skin with visible veins, and rupture of arteries, uterus, or intestines. Arterial complications are the leading cause of death in vascular EDS because they are unpredictable and surgical repair is diffic...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2010.48.6.528

    authors: Kim HS,Choi CH,Lee TH,Kim SP

    更新日期:2010-12-01 00:00:00

  • Astrocytoma in the third ventricle and hypothalamus presenting with parkinsonism.

    abstract::Parkinsonism secondary to intracranial mass lesions usually results from compression or distortion of the basal ganglia. Secondary parkinsonism due to midbrain infiltration or compression is rare and generally associated with other neurologic signs caused by pyramidal tract and/or cranial nerve involvement. We report ...

    journal_title:Journal of Korean Neurosurgical Society

    pub_type:

    doi:10.3340/jkns.2012.51.3.144

    authors: Choi KH,Choi SM,Nam TS,Lee MC

    更新日期:2012-03-01 00:00:00