Abstract：
:Glioblastoma (GBM) is a disease without any definite cure. Numerous approaches have been tested in efforts to conquer this brain disease, but patients invariably experience recurrence or develop resistance to treatment. New surgical tools, carefully chosen samples, and experimental methods are enabling discoveries at single-cell resolution. The present article reviews the cell-of-origin of isocitrate dehydrogenase (IDH)-wildtype GBM, beginning with the historical background for focusing on cellular origin and introducing the cancer genesis patterned on firework. The authors also review mutations associated with the senescence process in cells of the subventricular zone (SVZ), and biological validation of somatic mutations in a mouse SVZ model. Understanding GBM would facilitate research on the origin of other cancers and may catalyze the development of new management approaches or treatments against IDH-wildtype GBM.
journal_name
J Korean Neurosurg Socjournal_title
Journal of Korean Neurosurgical Societyauthors
Yoon SJ,Park J,Jang DS,Kim HJ,Lee JH,Jo E,Choi RJ,Shim JK,Moon JH,Kim EH,Chang JH,Lee JH,Kang SGdoi
10.3340/jkns.2019.0129subject
Has Abstractpub_date
2020-01-01 00:00:00pages
26-33issue
1eissn
2005-3711issn
1598-7876pii
jkns.2019.0129journal_volume
63pub_type
杂志文章abstract：:We report a rare case of Williams syndrome accompanying moyamoya disease in whom postoperative global cerebral infarction occurred unpredictably. Williams syndrome is an uncommon hereditary disorder associated with the connective tissue abnormalities and cardiovascular disease. To our knowledge, our case report is the...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2011.50.3.256
更新日期：2011-09-01 00:00:00
abstract：OBJECTIVE:Recently, regenerative therapies have been used in clinical trials (heart, cartilage, skeletal). We don't make use of these treatments to spinal cord injury (SCI) patients yet, but regenerative therapies are rising interest in recent study about SCI. Neural precursor/stem cell (NPSC) proliferation is a signif...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2016.59.5.437
更新日期：2016-09-01 00:00:00
abstract：:Among the spinal disorders, the treatment approach for spinal deformities has been discussed least among department of neurosurgery. But nowadays, more and more neurosurgeons are interested in spinal deformities as well as complex spinal disorders and are doing not a few surgeries for these kinds of disease. Neverthel...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2018.0150
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:Two-dimensional fluoroscopy-based computerized navigation for the placement of pedicle screws offers the advantage of using stored patient-specific imaging data in providing real-time guidance during screw placement. The study aimed to describe the accuracy and reliability of a fluoroscopy-based navigation sy...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2014.56.1.16
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:Transfemoral catheter angiography (TFCA) is a basic procedure in neurovascular surgery with increasing importance in surgical and non-invasive treatments. Unfortunately, resident neurosurgeons have relatively few opportunities to perform TFCA in most institutions. We report a method developed in our hospital ...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2013.54.2.81
更新日期：2013-08-01 00:00:00
abstract：:Sympathetic dysfunction is one of the possible complications of anterior spine surgery; however, it has been underestimated as a cause of complications. We report two successful experiences of treating severe dysesthetic pain occurring after anterior spine surgery, by performing a sympathetic block. The first patient ...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2014.56.1.66
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:To compare the clinical outcomes and biomechanical effects of total disc replacement (TDR) and posterior cervical foraminotomy (PCF) and to propose relative inclusion criteria. METHODS:Thirty-five patients who underwent surgery between 2006 and 2008 were included. All patients had single-level disease and on...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2015.0506.004
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to evaluate whether (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) can be used to assess the therapeutic response of brain abscess. METHODS:A study was conducted on 10 consecutive patients with brain abscess. Magnetic resonance imaging (MRI) with diffuse-weighte...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2011.49.5.278
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:The objective of this study is to investigate clinical characteristics, management methods and possible causes of intracranial fusiform aneurysm. METHODS:Out of a series of 2,458 intracranial aneurysms treated surgically or endovascularly, 22 patients were identified who had discrete fusiform aneurysms. Clin...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2008.44.3.116
更新日期：2008-09-01 00:00:00
abstract：:Gas pseudocysts are a rare cause of lumbar radiculopathy and most symptomatic gas pseudocysts are found within the confines of the spinal canal. A gas pseudocyst in the foramen causing lumbar radiculopathy is very rare. We present a case of a 67-year-old woman suffering from severe pain in the right leg. Computed tomo...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2010.47.3.232
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVE:We retrospectively evaluated the survival outcome of patients with brain metastasis from hepatocellular carcinoma (HCC). METHODS:Between 1991 and 2007, a total of 20 patients were diagnosed as having brain metastasis from HCC. The mean age of the patients was 55 +/- 13 years, and 17 (85.0%) were men. Sevente...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2010.47.5.325
更新日期：2010-05-01 00:00:00
abstract：OBJECTIVE:The objectives of this study were to analyze the recanalization rates and outcomes of multimodal therapy that consisted of sequential intravenous (IV)/intra-arterial (IA) thrombolysis, mechanical thrombolysis including mechanical clot disruption using microcatheters and microwires, balloon angioplasty, and st...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2009.45.6.360
更新日期：2009-06-01 00:00:00
abstract：OBJECTIVE:A groove technique for securing an electrode connector was described as an alternative surgical technique in deep brain stimulation (DBS) surgery to avoid electrode connector-related complications, such as skin erosion, infection, and migration. METHODS:We retrospectively reviewed 109 patients undergoing one...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2014.56.2.130
更新日期：2014-08-01 00:00:00
abstract：OBJECTIVE:Preoperative parameters including the T1 slope (T1S) and C2-C7 sagittal vertical axis (SVA) have been recognized as predictors of kyphosis after laminoplasty, which is accompanied by posterior neck muscle damage. The importance of preoperative parameters has been under-estimated in anterior cervical discectom...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2017.0404.001
更新日期：2017-09-01 00:00:00
abstract：:Cerebellar hemorrhage is an unusual complication of supratentorial neurosurgery. To the best of our knowledge, only three case reports have described the occurrence of cerebellar hemorrhage after burr hole drainage for the treatment of chronic subdural hematoma (SDH). We present the case of a patient with this rare po...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2009.46.6.592
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:The indications and optimal surgical treatments for intracranial cysts are controversial. In the present study, we describe long-term clinical and neuroimaging results of surgically treated intracranial cysts in children. The goal of this study is to contribute to the discussion of the debate. METHODS:This s...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2012.52.4.325
更新日期：2012-10-01 00:00:00
abstract：OBJECTIVE:The case fatality rate of nonlesional intracerebral hemorrhage (n-ICH) was high and not changed. Knowing the causes is important to their prevention; however, the reasons have not been studied. The aims of this study were to determine the cause of death, to improve the clinical outcomes. METHODS:We retrospec...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2014.55.1.1
更新日期：2014-01-01 00:00:00
abstract：OBJECTIVE:The aim of this study is to investigate good prognostic factors for an acute occlusion of a major cerebral artery using mechanical thrombectomy. METHODS:Between January 2013 to December 2014, 37 consecutive patients with acute occlusion of a major cerebral artery treated by mechanical thrombectomy with stent...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2015.58.3.192
更新日期：2015-09-01 00:00:00
abstract：:We describe a rare case of intradural-extramedullary primary spinal cysticercosis. A 42-year-old man visited our institute for lower back pain. He denied having consumed raw meet. Magnetic resonance (MR) images revealed an intradural pure cystic mass at the L3-L4 level. A radiologic diagnosis of spinal arachnoid cyst ...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2014.55.4.226
更新日期：2014-04-01 00:00:00
abstract：:A 65-year-old male presented with pain in his right medial calf. An imaging study revealed no acute lesions, and a diagnosis of saphenous neuralgia was made by a nerve conduction study. He received temporary pain relief with saphenous nerve blocks twice in a one-week interval. Pulsed radiofrequency neuromodulation red...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2013.54.2.136
更新日期：2013-08-01 00:00:00
abstract：:Ossification of the posterior longitudinal ligament (OPLL) in the thoracic spine is rare, even in the Far East. A 45-year-old female presented with a 4-month history of progressive motor weakness in the lower extremities, numbness below the midthoracic area, and spastic gait disturbance. Neuroradiological examinations...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2010.47.1.55
更新日期：2010-01-01 00:00:00
abstract：:Septic internal jugular vein-sigmoid sinus thrombosis (IJV-SST) associated with a malpositioned central venous catheter is a rare condition. It is potentially life-threatening and necessitates early diagnosis and rapid administration of appropriate medications. Unfortunately, it is difficult to diagnose due to vague c...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2013.53.3.183
更新日期：2013-03-01 00:00:00
abstract：OBJECTIVE:To examine the synergistic effects of both computer-assisted cognitive rehabilitation (CACR) and transcranial direct current stimulation (tDCS) on cognitive function in patients with stroke. METHODS:The current double-blind, sham-controlled study enrolled a total of 11 patients who were newly diagnosed with ...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2013.54.6.484
更新日期：2013-12-01 00:00:00
abstract：:Injury to the vertebral artery during anterior cervical discectomy is rare but potentially fatal. We report a case of cerebellar infarction after endovascular embolization for iatrogenic vertebral artery injury at C5-C6 during an anterior cervical discectomy and fusion. A 61-year-old man had an intraoperative injury o...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2011.50.6.520
更新日期：2011-12-01 00:00:00
abstract：Objective:To explore the correlation between the polymorphism of histone deacetylase 9 gene (rs1060499865, rs723296, rs957960) and ischemic stroke (IS) in Chinese Han population in Dali region. Methods:This study included 155 IS patients and 128 healthy physical examinees. TaqMan-polymerase chain reaction technology a...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2020.0040
更新日期：2020-11-24 00:00:00
abstract：OBJECTIVE:To report a minimally invasive treatment option using percutaneous pedicle screw fixation with adjuvant treatment for metastatic thoraco-lumbar and lumbar spinal tumors. METHODS:This is a retrospective study of charts of patients with spinal metastases. All were older than 18 years of age and were considered...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2015.57.2.100
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:The inter-rater reliability of the modified Knosp's classification was measured before the analysis. The clinical validity of the parasellar extension grading system was evaluated by investigating the extents of resection and complication rates among the grades in the endoscopic endonasal transsphenoidal surg...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2016.59.6.577
更新日期：2016-11-01 00:00:00
abstract：OBJECTIVE:To investigate the feasibility of C1 lateral mass screw and C2 pedicle screw with polyaxial screw and rod system supplemented with miniplate for interlaminar fusion to treat various atlantoaxial instabilities. METHODS:After posterior atlantoaxial fixation with lateral mass screw in the atlas and pedicle scre...
journal_title：Journal of Korean Neurosurgical Society
pub_type： 杂志文章
doi：10.3340/jkns.2012.52.2.120
更新日期：2012-08-01 00:00:00
abstract：:Carotid occlusion is an inevitable therapeutic modality for the treatment of complex aneurysms such as giant, traumatic, and intracavernous aneurysms. Late complications of carotid occlusion include 'de novo' aneurysm formation at a distant site because of hemodynamic changes in the circle of Willis. We report a case ...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2009.45.4.236
更新日期：2009-04-01 00:00:00
abstract：:A 61-year-old woman with a very rare case of totally ossified large thoracic spinal metaplastic meningioma, showing progressing myelopathy is presented. Computed tomographic images showed a large totally ossfied intradural round mass occupying the spinal canal on T9-10 level. Magnetic resonance imaging revealed a larg...
journal_title：Journal of Korean Neurosurgical Society
pub_type：
doi：10.3340/jkns.2013.54.3.257
更新日期：2013-09-01 00:00:00
