Abstract:
OBJECTIVE:Recently, regenerative therapies have been used in clinical trials (heart, cartilage, skeletal). We don't make use of these treatments to spinal cord injury (SCI) patients yet, but regenerative therapies are rising interest in recent study about SCI. Neural precursor/stem cell (NPSC) proliferation is a significant event in functional recovery of the central nervous system (CNS). However, brain NPSCs and spinal cord NPSCs (SC-NPSCs) have many differences including gene expression and proliferation. The purpose of this study was to investigate the influence of neural growth factor (NGF) on the proliferation of SC-NPSCs. METHODS:NPSCs (2×10(4)) were suspended in 100 µL of neurobasal medium containing NGF-7S (Sigma-Aldrich) and cultured in a 96-well plate for 12 days. NPSC proliferation was analyzed five times for either concentration of NGF (0.02 and 2 ng/mL). Sixteen rats after SCI were randomly allocated into two groups. In group 1 (SCI-vehicle group, n=8), animals received 1.0 mL of the saline vehicle solution. In group 2 (SCI-NGF group, n=8), the animals received single doses of NGF (Sigma-Aldrich). A dose of 0.02 ng/mL of NGF or normal saline as a vehicle control was intra-thecally injected daily at 24 hour intervals for 7 days. For Immunohistochemistry analysis, rats were sacrificed after one week and the spinal cords were obtained. RESULTS:The elevation of cell proliferation with 0.02 ng/mL NGF was significant (p<0.05) but was not significant for 2 ng/mL NGF. The optical density was increased in the NGF 0.02 ng/mL group compared to the control group and NGF 2 ng/mL groups. The density of nestin in the SCI-NGF group was significantly increased over the SCI-vehicle group (p<0.05). High power microscopy revealed that the density of nestin in the SCI-NGF group was significantly increased over the SCI-vehicle group. CONCLUSION:SC-NPSC proliferation is an important pathway in the functional recovery of SCI. NGF enhances SC-NPSC proliferation in vitro and in vivo. NGF may be a useful option for treatment of SCI patients pending further studies to verify the clinical applicability.
journal_name
J Korean Neurosurg Socjournal_title
Journal of Korean Neurosurgical Societyauthors
Han Y,Kim KTdoi
10.3340/jkns.2016.59.5.437subject
Has Abstractpub_date
2016-09-01 00:00:00pages
437-41issue
5eissn
2005-3711issn
1598-7876journal_volume
59pub_type
杂志文章abstract:OBJECTIVE:This 2009-2011 nation-wide study of adult Koreans was aimed to provide characteristics, medical utilization states, and survival rates for newly diagnosed patients with primary nonmalignant and malignant spine tumors. METHODS:Data for patients with primary spine tumors were selected from the Korean Health In...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2016.0505.011
更新日期:2017-03-01 00:00:00
abstract:OBJECTIVE:Posture-induced radial neuropathy, known as Saturday night palsy, occurs because of compression of the radial nerve. The clinical symptoms of radial neuropathy are similar to stroke or a herniated cervical disk, which makes it difficult to diagnose and sometimes leads to inappropriate evaluations. The purpose...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2014.55.3.148
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the optimal volume of injected cement and its distribution when used to treat vertebral compression fractures, and to identify factors related to subsequent vertebral fractures. METHODS:A retrospective analysis of newly developing vertebral fractures after percutane...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2010.48.2.125
更新日期:2010-08-01 00:00:00
abstract::Parkinsonism secondary to intracranial mass lesions usually results from compression or distortion of the basal ganglia. Secondary parkinsonism due to midbrain infiltration or compression is rare and generally associated with other neurologic signs caused by pyramidal tract and/or cranial nerve involvement. We report ...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2012.51.3.144
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the different patterns of bone loss between the lumbar spine and the femur after ovariectomy in rats. METHODS:Twenty-four female Sprague-Dawley rats underwent a sham operation (the sham group) or bilateral ovariectomy (the ovariectomized group). Four and eight weeks ...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2012.52.1.1
更新日期:2012-07-01 00:00:00
abstract::Glioblastoma (GBM) is a disease without any definite cure. Numerous approaches have been tested in efforts to conquer this brain disease, but patients invariably experience recurrence or develop resistance to treatment. New surgical tools, carefully chosen samples, and experimental methods are enabling discoveries at ...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2019.0129
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVE:Meningioma is the second most common primary central nervous system neoplasm. In contrast, chordoid meningioma is rare; due to the paucity of cases, little is known about its clinical features or treatment outcomes. The objectives of this study were to describe the clinical characteristics and outcomes for pa...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2014.56.3.194
更新日期:2014-09-01 00:00:00
abstract::GBM is the most common primary brain tumor, but intraventricular GBM is rare and only few cases have been reported in the literature. The authors report a case of 64-year-old man who had a remote history of previous periventricular intracerebral hemorrhage. Brain computed tomography (CT) and magnetic resonance (MR) im...
journal_title:Journal of Korean Neurosurgical Society
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doi:10.3340/jkns.2008.44.6.405
更新日期:2008-12-01 00:00:00
abstract::Ehlers-Danlos syndrome (EDS) type IV is characterized by its clinical manifestations, which are easy bruising, thin skin with visible veins, and rupture of arteries, uterus, or intestines. Arterial complications are the leading cause of death in vascular EDS because they are unpredictable and surgical repair is diffic...
journal_title:Journal of Korean Neurosurgical Society
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doi:10.3340/jkns.2010.48.6.528
更新日期:2010-12-01 00:00:00
abstract::Malignant peripheral nerve sheath tumors (MPNSTs) are very rare tumors. We experienced a case of MPNST in the cervical paraspinal space which was not associated with neurofibromatosis. The tumor located in left C6-7 foramen and compressed C7 root. The tumor was removed through the occipital triangle. We report a case ...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2008.44.2.91
更新日期:2008-08-01 00:00:00
abstract::We report a case of pedicle screw loosening treated by modified transpedicular screw augmentation technique using polymethylmethacrylate (PMMA), which used the anchoring effect of hardened PMMA. A 56-year-old man who had an L3/4/5 fusion operation 3 years ago complained of continuous low back pain after this operation...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2011.49.1.75
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:Microvascular decompression (MVD) for hemifacial spasm (HFS) involving the vertebral artery (VA) can be technically challenging. We investigated the therapeutic effects of a bioglue-coated Teflon sling technique on the VA during MVD in 42 cases. METHODS:A bioglue-coated Teflon sling was crafted by the surgeo...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2016.59.5.505
更新日期:2016-09-01 00:00:00
abstract::Various approaches have been attempted in translational moyamoya disease research. One promising material for modeling and treating this disease is vascular progenitor cells, which can be acquired and expanded from patient peripheral blood. These cells may provide a novel experimental model and enable us to obtain ins...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章,评审
doi:10.3340/jkns.2015.57.6.428
更新日期:2015-06-01 00:00:00
abstract::Mild traumatic brain injury is common in elderly patients, many of whom are on anticoagulant. The common practice is to discharge these patients from the emergency room if the computed tomography (CT) of the brain is normal. However, a very small proportion of these patients may develop a life threatening intracranial...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2014.55.1.51
更新日期:2014-01-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2011.50.5.434
更新日期:2011-11-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2017.0404.001
更新日期:2017-09-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2018.0045
更新日期:2018-09-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2015.57.1.23
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journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2013.54.1.42
更新日期:2013-07-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2009.45.6.360
更新日期:2009-06-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type:
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更新日期:2015-12-01 00:00:00
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更新日期:2015-11-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type:
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更新日期:2014-07-01 00:00:00
abstract::Oblique basal skull fractures resulting from lateral crushing injuries involving both clivus and occipital condyle are rare due to their deep locations. Furthermore, these fractures may present clinically with multiple cranial nerve injuries because neural exit routes are restricted in this intricate region. The autho...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
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更新日期:2012-05-01 00:00:00
abstract::We describe a rare case of intradural-extramedullary primary spinal cysticercosis. A 42-year-old man visited our institute for lower back pain. He denied having consumed raw meet. Magnetic resonance (MR) images revealed an intradural pure cystic mass at the L3-L4 level. A radiologic diagnosis of spinal arachnoid cyst ...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2014.55.4.226
更新日期:2014-04-01 00:00:00
abstract::We report a supratentorial primitive neuroectodermal tumor (sPNET) in 17-year-old primipara in the second trimester her pregnancy. Magnetic resonance imaging revealed a left frontoparietal mass with solid and cystic component. Gross-total resection was achieved via a left frontoparietal craniotomy. It was decided to s...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2009.45.1.39
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:This study characterized the neurons in the lumbosacral cord that express phospho ERK (pERK) after distension or irritation of the bladder, and their relation to the vanilloid receptor 1 (VR1) positive primary afferents. METHODS:Mechanical distension and chemical irritation of the bladder were induced by int...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2007.42.6.462
更新日期:2007-12-01 00:00:00
abstract::We present an extremely rare case of the atypical choroid plexus papilloma in an adult which developed at the trigone of right lateral ventricle. A 62-year-old woman presented with the history of intermittent and gradually progressive headache and left side hemiparesis for 6 months. The brain magnetic resonance image ...
journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2009.46.1.74
更新日期:2009-07-01 00:00:00
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journal_title:Journal of Korean Neurosurgical Society
pub_type:
doi:10.3340/jkns.2013.53.5.316
更新日期:2013-05-01 00:00:00
abstract:OBJECTIVE:The objective of study is to evaluate the incidence of leptomeningeal carcinomatosis (LMC) in breast cancer patients with parenchymal brain metastases (PBM) and clinical risk factors for the development of LMC. METHODS:We retrospectively analyzed 27 patients who had undergone surgical resection (SR) and 156 ...
journal_title:Journal of Korean Neurosurgical Society
pub_type: 杂志文章
doi:10.3340/jkns.2012.52.3.193
更新日期:2012-09-01 00:00:00