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Plasma levels of MMP-2, MMP-9 and TIMP-1 are not associated with arterial stiffness in subjects with type 2 diabetes mellitus.

Abstract：

OBJECTIVE:Increased arterial stiffness is a marker of atherosclerosis and is recognised early in the course of type 2 diabetes mellitus (T2DM). Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are a family of proteolytic enzymes which are essential for the structure and function of large arteries. In this study, we examined for relationships between MMP and TIMP-1 and indices of arterial stiffness in subjects with T2DM. RESEARCH DESIGN AND METHODS:A total of 60 subjects with T2DM and 60 nondiabetic subjects were recruited. Aortic distensibility (AD) was assessed noninvasively by ultrasonography and augmentation index by pulse wave analysis. RESULTS:The values of AD were lower in subjects with T2DM than in controls (P<.001), while those of augmentation index were not significantly different between the two groups. Plasma concentrations of MMP-2 and MMP-9 were not different between diabetic and nondiabetic participants, while those of TIMP-1 were lower in the diabetic patients (P=.005). In the diabetes group, no significant associations were found between either AD or augmentation index and MMPs as well as TIMP-1, while duration of diabetes emerged as the strongest predictor of AD (P<.001). In the nondiabetic group, nonsignificant associations were also found between AD or augmentation index and MMPs as well as TIMP-1. CONCLUSION:In patients with T2DM, plasma levels of MMP and TIMP-1 are not associated with arterial stiffness assessed by either AD or augmentation index.

journal_name

J Diabetes Complications

journal_title

Journal of diabetes and its complications

authors

Papazafiropoulou A,Perrea D,Moyssakis I,Kokkinos A,Katsilambros N,Tentolouris N

doi

10.1016/j.jdiacomp.2008.10.004

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

20-7

issue

1

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(08)00110-4

journal_volume

24

pub_type

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