Community-acquired infections in type 2 diabetic patients and their nondiabetic partners. The Fremantle Diabetes Study.

Abstract:

AIMS:The aim of this study was to investigate the association between Type 2 diabetes and community-acquired infections. METHODS:We recruited 68 patients (mean+/-S.D. age=64.9+/-9.1 years; 57.4% males) from a community-based cohort and their nondiabetic partners (age=63.8+/-9.9 years; mean relationship duration=37.3+/-11.5 years) to a prospective observational matched-pair cohort study. Participants were assessed for infection risk factors and were required to complete an infection diary over the following year. RESULTS:Sixty patient-partner pairs returned completed diaries. A greater proportion of patients than partners had received influenza vaccination in the past year (73.3% vs. 60.0%; P=.057), but pneumococcal vaccination coverage in the previous 5 years was similar (11.7% vs. 10.0%; P=1.0). The proportions of patients and partners reporting no infections were similar (51.7% vs. 58.3%; P=.52), but the diabetic patients were more likely to have experienced more than one infection (33.3% vs. 18.3%: P=.022). Baseline glycosylated hemoglobin levels in patients with and without at least one infection were similar, and there was no association between multiple infections and glycosylated hemoglobin (P>.2 in each case). After adjusting for age and gender, the probability of at least one infection during follow-up was not associated with diabetes (P=.33), but the number of infections was positively associated with diabetes (P=.005). CONCLUSION/INTERPRETATION:Although similar proportions of Type 2 diabetic patients and their nondiabetic partners remained infection-free over a 12-month period, the diabetic patients who developed infections had a greater number of episodes. Glycemic control did not predict the risk or frequency of community-acquired infections in the diabetic group.

authors

Davis TM,Weerarathne T,Foong Y,Mason C,Davis WA

doi

10.1016/j.jdiacomp.2005.03.003

keywords:

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

259-63

issue

5

eissn

1056-8727

issn

1873-460X

pii

S1056-8727(05)00028-0

journal_volume

19

pub_type

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