Abstract:
AIMS:Diabetic nephropathy (DN) that progress to end stage renal failure is a serious health problem. Autophagy is involved in DN pathogenesis. Finding renal prognostic biomarkers can help in the future renal status prevision. Therefore, the aim of current study was to evaluate and correlate circulating levels of autophagy regulator protein Unc-51-like kinase 1 (ULK-1) with the widely expressed receptor in mammalian kidney; epidermal growth factor receptor (EGFR); and the key functional podocyte protein podocin (PDCN). METHODS:Serum levels were assessed by ELISA in 72 type 2 diabetic patients classified according to their urinary albumin/creatinine ratio; 19 normoalbuminuric, 37 microalbuminuric and 16 macroalbuminuric patients; age and sex matched with 18 healthy controls. RESULTS:Microalbuminuria and macroalbuminuria patients exhibited decreased ULK-1, EGFR and PDCN levels. Only EGFR showed lower levels in normoalbuminuria compared with controls. ULK-1 and EGFR were significantly higher in normoalbuminuria compared with microalbuminuria and macroalbuminuria patients. ULK-1, EGFR and PDCN were correlated with each other and with some metabolic parameters. CONCLUSIONS:ULK-1 with EGFR can predict early impairment in DN while PDCN can highlight progressive DN risk EGFR and PDCN may interact synergistically with ULK-1 in autophagy dysregulation as a pathogenic mechanism of DN induction and progression.
journal_name
J Diabetes Complicationsjournal_title
Journal of diabetes and its complicationsauthors
El-Shazly AAA,Sallam AM,El-Hefnawy MH,El-Mesallamy HOdoi
10.1016/j.jdiacomp.2018.11.007subject
Has Abstractpub_date
2019-02-01 00:00:00pages
128-133issue
2eissn
1056-8727issn
1873-460Xpii
S1056-8727(18)31181-4journal_volume
33pub_type
杂志文章abstract:AIMS:To identify how efforts to control the diabetes epidemic and the resulting changes in diabetes mellitus, type II (T2D) incidence and survival have affected the time-trend of T2D prevalence. METHODS:A newly developed method of trend decomposition was applied to a 5% sample of Medicare administrative claims filed b...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2017.12.014
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:Matrix metalloproteinases (MMPs) play an important role in pathogenesis of atherosclerosis and vascular disease. We hypothesized that MMP-2 might be a susceptibility gene for cardiovascular disease (CVD) in diabetes. The aim of this study was to evaluate the association between C(-1306)T functional polymorphi...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2015.05.004
更新日期:2015-08-01 00:00:00
abstract:AIMS:Metformin treatment is associated with a decrease of serum vitamin B12, but whether this reflects tissue B12 deficiency is controversial. We studied the effects of metformin on serum levels of methylmalonic acid (MMA), a biomarker for tissue B12 deficiency, and on onset or progression of neuropathy. METHODS:In th...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2017.11.001
更新日期:2018-02-01 00:00:00
abstract::Currently, neither the American Diabetes Association nor the Kidney Foundation consider the results of a positive dipstick urine test for protein, a semi-quantitative measurement, in the final evaluation of diabetic nephropathy. Instead, they require a quantitative test. The object of this study was to assess whether ...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(98)00017-8
更新日期:1999-01-01 00:00:00
abstract::Although higher levels of hemoglobin A1c (HbA1c) and blood pressure precede the development of nephropathy in Type 1 diabetes (T1DM), the relationship between glycemic control and cardiovascular factors early in the course of diabetes is not clear. We conducted a retrospective study from clinic data for a 1-year perio...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/S1056-8727(03)00031-X
更新日期:2004-07-01 00:00:00
abstract::The aim of this cross-sectional study was to determine the significant limitations, sensitivity, specificity, partial correlations, and odds ratios of nutrient intake in patients with and without hypertension with Type 2 diabetes mellitus. Diabetic patients (n=220) with clinical diagnosis of hypertension and diabetic ...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2008.02.005
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVES:Obesity is known to be an important risk factor for type 2 diabetes and its related comorbid conditions; however, its specific impact on generic health-related quality of life (HRQL) is less clear. The objective of this study was to estimate the association between body mass index (BMI) and HRQL in individua...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2012.05.008
更新日期:2012-09-01 00:00:00
abstract:AIMS:To investigate the discontinuation of oral antihyperglycemic agents (OHA), and examine factors associated with OHA discontinuation, and the effect of OHA discontinuation on glycemic control and healthcare utilization among diabetes patients prescribed dual OHA therapy. METHODS:We identified 23,612 adult patients ...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2016.07.021
更新日期:2016-01-01 00:00:00
abstract::The aim of this study was to determine the factors associated with diabetic peripheral neuropathy and more particularly its relation to precisely assessed microangiopathy. Peripheral neuropathy was assessed in 135 diabetic patients: 28 insulin-dependent diabetes mellitus (IDDM), 85 non-insulin-dependent diabetes melli...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(95)00086-0
更新日期:1997-01-01 00:00:00
abstract::We randomized 102 patients with insulin-dependent diabetes to intensified treatment (n = 48 at baseline, n = 42 after 7.5 years) or standard treatment (n = 54 at baseline, n = 47 after 7.5 years). As has previously been reported, intensified treatment resulted in a retardation of retinopathy, nephropathy, and neuropat...
journal_title:Journal of diabetes and its complications
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/1056-8727(94)00008-c
更新日期:1995-01-01 00:00:00
abstract:BACKGROUND:Apolipoprotein A-II (ApoA-II) constitutes approximately 20% of the total HDL protein content. The results of various studies on the relationship between cardiovascular diseases (CVD) and the plasma ApoA-II level are contradictory. The aim of this study was to determine the relationship between ApoA-II polymo...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2015.05.024
更新日期:2015-09-01 00:00:00
abstract:AIMS:In the Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes (EMPA-REG) trial, empagliflozin reduced cardiovascular and all-cause mortality in type 2 diabetes (T2D) patients at high cardiovascular risk. We sought to estimate the cost-effectiveness of empagliflozin versus standard treatment for t...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2017.10.006
更新日期:2018-02-01 00:00:00
abstract::In patients with insulin-dependent diabetes mellitus (IDDM), albuminuria reflects widespread vascular dysfunction. Albuminuria has been associated to defects of heparan sulfate proteoglycan (HSPG) within the extracellular matrix. Our hypothesis is that loss of HSPG in vascular walls reduces the HSPG-bound lipoprotein-...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(96)00048-7
更新日期:1997-07-01 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) significantly increases morbidity and mortality from cardiovascular disease (CVD). Treatments for patients with T2DM have the potential to reduce cardiovascular (CV) risk. This review focuses on the potential of a new class of antidiabetic agents, the sodium glucose cotransporter 2 (SGL...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章,评审
doi:10.1016/j.jdiacomp.2012.12.004
更新日期:2013-05-01 00:00:00
abstract:AIMS:To investigate the effect of a single nucleotide polymorphism (SNP) in transmembrane protein 182 (TMEM182) on the risk of having central obesity and the related phenotype. METHODS:In total, 2141 subjects with central obesity (n = 827) and normal controls (n = 1314) were included. The most strongly associated SNPs...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2020.107732
更新日期:2020-12-01 00:00:00
abstract:AIMS:Investigate the importance of treating diabetes by evaluating mortality risk of untreated and medically-treated diabetic patients. METHODS:Historical prospectively collected observational data of hospitalized patient ≥18years, admitted for any-cause to medical wards, between January 2011 and December 2013. Main o...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2016.04.011
更新日期:2016-08-01 00:00:00
abstract::Paecilomyces is a saprophytic soil fungus that is an uncommon human pathogen. We report a diabetic patient who developed an upper lobe pulmonary infection due to Paecilomyces varioti. This pneumonia responded poorly to oral imidazole therapy with ketoconazole. Eventual treatment of the chronic infiltrating process req...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/1056-8727(92)90027-i
更新日期:1992-04-01 00:00:00
abstract::Diabetes mellitus (DM) is a metabolic disorder of glucose homeostasis caused by insufficient secretion or inadequate action of insulin. Nowadays, the increased morbidity of DM is a worldwide issue. Pancreatic beta cell death plays a key role in the progress of DM, especially Type 1 diabetes (T1D). Traditional biomarke...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章,评审
doi:10.1016/j.jdiacomp.2017.08.012
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:Controversy remains as to the effects of type 2 diabetes on bone metabolism. The aims of this study were to assess the association between type 2 diabetes and bone mineral density (BMD) and to evaluate the possible relationship between chronic diabetic complications and bone density. METHODS:Bone mineral de...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2007.06.004
更新日期:2009-01-01 00:00:00
abstract:AIM:To analyse the OGTT glycemic parameters - fasting, 1h and 2h plasma glucose values singly and in various combinations; with respect to their prediction of future dysglycemia in subjects with normal glucose tolerance (NGT). METHODS:Electronic medical records of individuals who underwent an OGTT between 1991 and 201...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2017.07.017
更新日期:2017-11-01 00:00:00
abstract::Women with diabetes mellitus (DM) have urinary tract infection (UTI) more often than women without DM. It is unknown, however, what the prevalence and type of renal damage due to UTI is in these women. Therefore, in this study, we compared type 2 DM women with or without UTI history for the prevalence and type of rena...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/s1056-8727(02)00222-2
更新日期:2003-09-01 00:00:00
abstract:AIMS:To highlight the differences between eight international expert panel diagnostic criteria (either current or outdated but in use) for the diagnosis of gestational diabetes mellitus (GDM) and implications of switching to the International Association of Diabetes in Pregnancy Study Groups (IADPSG) criterion. METHOD...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2015.03.006
更新日期:2015-05-01 00:00:00
abstract::A 27-year-old male, who had developed diabetes mellitus type 1 (DMT1) since the age of eighteen and alopecia areata universalis nine months later, attended the outpatient clinics complaining of general fatigue and shortness of breath. A Schilling test was indicative of pernicious anemia. Antigastric parietal cell (AGP...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2008.05.003
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVES:Hyperglycemia-induced inflammation is central to the vascular complications in diabetes. Toll-like receptors (TLRs) are key players in regulating inflammatory responses. There are sparse data on the role of TLR2 and TLR4 in regulating human macrovascular aortic endothelial cells (HMAECs) inflammation and gly...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2016.01.014
更新日期:2016-05-01 00:00:00
abstract:BACKGROUND:Vascular complications are the leading cause of morbidity and mortality among patients with type 1 and type 2 diabetes mellitus. These vascular abnormalities result of a chronic hyperglycemic state, which leads to an increase in oxidative stress and inflammatory responses. AIM:This review addresses the rela...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章,评审
doi:10.1016/j.jdiacomp.2015.12.018
更新日期:2016-05-01 00:00:00
abstract:OBJECTIVES:What is the prognostic significance of achieving a systolic blood pressure of <140 mmHg? SETTING:Diabetic renal policlinic, university hospital of Lund, Sweden. SUBJECTS:118 type 2 diabetic patients with micro-macroalbuminuria were followed for four years (range 1-8 years). METHOD AND MAIN OUTCOME MEASURES...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2012.05.020
更新日期:2012-11-01 00:00:00
abstract:AIMS:The present study investigated the association of serum levels of angiopoietin-related growth factor (AGF) with lower extremity peripheral arterial disease (LEPAD). METHODS:The study group is comprised of 105 patients with lower extremity peripheral arterial disease. The control group consisted of 80 individuals ...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2016.10.019
更新日期:2017-02-01 00:00:00
abstract:AIMS:To investigate TAp63 expression in patients with type 2 diabetes mellitus (T2DM) and the potential correlations between TAp63 and proinflammatory cytokines production and other clinical parameters. METHODS:Peripheral blood mononuclear cells (PBMCs) and plasma were collected from 72 T2DM (cases) and 72 healthy sub...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2017.12.013
更新日期:2018-03-01 00:00:00
abstract:AIMS:To investigate the predictive capability of insulin resistance surrogate markers for insulin resistance and arterial stiffness based on sex. METHODS:We assessed the association of triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), visceral adiposity index (VAI...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2019.107442
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:Although diabetic kidney disease (DKD) has been considered as a glomerulocentric disease in the past few decades, growing evidence demonstrated that tubular damage was indispensable in its pathogenesis and progression. This study was designed to investigate the association of urinary acidification dysfunction...
journal_title:Journal of diabetes and its complications
pub_type: 杂志文章
doi:10.1016/j.jdiacomp.2019.107419
更新日期:2019-11-01 00:00:00