Extracellular nucleotides and interleukin-8 production by ARPE cells: potential role of danger signals in blood-retinal barrier activation.

abstract：PURPOSE:Reports of lymphatics in the posterior human uvea are contradictory. We systematically analyzed the choroid by combining various lymphatic markers, following recently established guidelines for the immunohistochemical detection of ocular lymphatics. METHODS:Human choroids were prepared for flat mount serial cr...

journal_title：Investigative ophthalmology & visual science

authors： Schrödl F,Kaser-Eichberger A,Trost A,Strohmaier C,Bogner B,Runge C,Motloch K,Bruckner D,Laimer M,Heindl LM,Reitsamer HA

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:To characterize the expression patterns of myosin heavy chain (MyHC) isoforms in mouse extraocular muscles (EOMs) during postnatal development. METHODS:MyHC isoform expression in mouse EOMs from postnatal day (P)0 to 3 months was evaluated by quantitative polymerase chair reaction (qPCR) and immunohistochemist...

journal_title：Investigative ophthalmology & visual science

authors： Zhou Y,Liu D,Kaminski HJ

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:To investigate the neural basis of contraction anisocoria and any implications for assessments using pupillary responses, through analysis of topographic variation in amplitudes of direct and consensual pupil responses. METHODS:Direct and consensual pupillary contraction amplitudes were analyzed from six studi...

journal_title：Investigative ophthalmology & visual science

authors： Carle CF,Maddess T,James AC

更新日期：2011-04-12 00:00:00

abstract：:Class II (DR or Ia) alloantigens are potent inducers of cell-mediated immune responses. However, the expression of Class II alloantigens on corneal cells, except for Langerhans cells within the limbal epithelium, has not previously been described. We have induced Ia expression on cultured rabbit corneal endothelial ce...

journal_title：Investigative ophthalmology & visual science

authors： Donnelly JJ,Li WY,Rockey JH,Prendergast RA

更新日期：1985-04-01 00:00:00

abstract：PURPOSE:To determine the impact of repetitive nonlethal oxidant injury with hydroquinone (HQ) on regulation of cell membrane blebbing and molecules, which are essential in extracellular matrix turnover (ECM) maintenance, especially matrix metalloproteinase (MMP)-2, tissue inhibitor of MMP (TIMP)-2, and type IV collagen...

journal_title：Investigative ophthalmology & visual science

authors： Marin-Castaño ME,Striker GE,Alcazar O,Catanuto P,Espinosa-Heidmann DG,Cousins SW

更新日期：2006-09-01 00:00:00

abstract：PURPOSE:Previous studies have demonstrated a role for the retinal pigment epithelium (RPE) in the development and maintenance of the choroidal vasculature, suggesting that RPE serves a trophic role for the choroidal vessels. The goal of this study was to determine the expression pattern of vascular endothelial growth f...

journal_title：Investigative ophthalmology & visual science

authors： Saint-Geniez M,Maldonado AE,D'Amore PA

更新日期：2006-07-01 00:00:00

abstract：PURPOSE:Transforming growth factor beta-induced (TGFBI)-related dystrophies constitute the most common heritable forms of corneal dystrophy worldwide. However, other than the underlying genotypes of these conditions, a limited knowledge exists of the exact pathomechanisms of these disorders. This study expands on our p...

journal_title：Investigative ophthalmology & visual science

authors： Courtney DG,Poulsen ET,Kennedy S,Moore JE,Atkinson SD,Maurizi E,Nesbit MA,Moore CB,Enghild JJ

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:To assess the postural stability and gait characteristics of adults with age-related maculopathy (ARM) and to identify the visual factors associated with postural stability and gait in this clinical population. METHODS:Participants included 80 individuals with a range of severity of ARM (mean age, 77.2 years)....

journal_title：Investigative ophthalmology & visual science

authors： Wood JM,Lacherez PF,Black AA,Cole MH,Boon MY,Kerr GK

更新日期：2009-01-01 00:00:00

abstract：Purpose:To test the amblyopic suppression at mid to low spatial frequencies when compensating for signal attenuation. Methods:Eight amblyopes with (n = 5) or without (n = 3) strabismus and 10 normal controls with normal or corrected to normal visual acuity (≥20/20) and normal stereopsis (≤40 arcseconds) participated. ...

journal_title：Investigative ophthalmology & visual science

authors： Zhou J,Reynaud A,Yao Z,Liu R,Feng L,Zhou Y,Hess RF

更新日期：2018-08-01 00:00:00

abstract：:Heightened interest in meibomian glands dysfunction prompted the authors to examine the ultrastructure of the glandular epithelium in specimens of surgical origin, by thin section and freeze-fracture electron microscopies. In meibomian glands, the morphology and ultrastructure of acinar cells varies considerably accor...

journal_title：Investigative ophthalmology & visual science

authors： Sirigu P,Shen RL,Pinto da Silva P

更新日期：1992-06-01 00:00:00

abstract：PURPOSE:To describe and analyze developmental change from birth through maturity of human electroretinogram (ERG) response, especially in terms of rod phototransduction as represented in the ERG a-wave. METHODS:Electroretinograms were recorded from 16 human infants from 5 to 270 days of age, two children 1.9 and 3.4 y...

journal_title：Investigative ophthalmology & visual science

authors： Breton ME,Quinn GE,Schueller AW

更新日期：1995-07-01 00:00:00

abstract：Purpose:Lens epithelial cell (LEC) conversion to myofibroblast is responsible for fibrotic cataract surgery complications including posterior capsular opacification. While transforming growth factor beta (TGFβ) signaling is important, the mechanisms by which the TGFβ pathway is activated post cataract surgery (PCS) are...

journal_title：Investigative ophthalmology & visual science

authors： Jiang J,Shihan MH,Wang Y,Duncan MK

更新日期：2018-10-01 00:00:00

abstract：Purpose:To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects. Methods:Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RT...

journal_title：Investigative ophthalmology & visual science

authors： Lin Y,Jiang H,Liu Y,Rosa Gameiro G,Gregori G,Dong C,Rundek T,Wang J

更新日期：2019-02-01 00:00:00

abstract：Purpose:To assess the phenotypic variability and natural course of inherited retinal diseases (IRDs) caused by EYS mutations. Methods:Multiethnic cohort study (N = 30) with biallelic EYS variants from a clinical IRD database (retinitis pigmentosa [RP], N = 27; cone-rod dystrophy [CRD], N = 1; and macular dystrophy, N ...

journal_title：Investigative ophthalmology & visual science

authors： Pierrache LHM,Messchaert M,Thiadens AAHJ,Haer-Wigman L,de Jong-Hesse Y,van Zelst-Stams WAG,Collin RWJ,Klaver CCW,van den Born LI

更新日期：2019-05-01 00:00:00

abstract：PURPOSE:To explore changes in iris curvature over a 2-year period. To investigate associations between iris curvature and ocular biometric parameters. To explore relationships between a number of nonocular measurements and ocular biometric parameters. METHODS:Schoolboys enrolled 2 years previously were invited to retu...

journal_title：Investigative ophthalmology & visual science

authors： Shah A,Lascaratos G,Garway-Heath DF,Foster PJ,Barton K

更新日期：2014-06-10 00:00:00

abstract：PURPOSE:Age-related nuclear cataracts involve denaturation and aggregation of intracellular proteins. We have documented age-dependent changes in membrane transport in the mouse lens to see what might initiate changes in the intracellular milieu. METHODS:Microelectrode-based intracellular impedance studies of intact l...

journal_title：Investigative ophthalmology & visual science

authors： Gao J,Wang H,Sun X,Varadaraj K,Li L,White TW,Mathias RT

更新日期：2013-11-01 00:00:00

abstract：PURPOSE:To assess the impact of zinc finger E-box binding homeobox 1 (ZEB1) gene mutations associated with posterior polymorphous corneal dystrophy 3 (PPCD3) and Fuchs' endothelial corneal dystrophy (FECD). METHODS:Thirteen of the 27 previously reported ZEB1 truncating mutations associated with PPCD3 and the six previ...

journal_title：Investigative ophthalmology & visual science

authors： Chung DW,Frausto RF,Ann LB,Jang MS,Aldave AJ

更新日期：2014-09-04 00:00:00

abstract：PURPOSE:Lectin studies have shown that in the rabbit corneal epithelium, alpha-2,3 sialylation of O-linked glycans differentiates limbal and corneal epithelial cell phenotypes. Because sialic acid can be regulated at the level of the expression of sialyltransferases (STs), the purpose of the present study was to analyz...

journal_title：Investigative ophthalmology & visual science

authors： Matic M,Petrov I,Stegman Z,Buku A,Wolosin JM

更新日期：1998-05-01 00:00:00

abstract：PURPOSE:To determine the association between ocular dominance and spherical or astigmatic anisometropia, age, and sex. METHODS:Medical records of 10,264 myopic refractive surgery candidates were filtered. Ocular dominance was assessed with the hole-in-the-card test. Manifest refractive error was measured in each subje...

journal_title：Investigative ophthalmology & visual science

authors： Linke SJ,Baviera J,Munzer G,Steinberg J,Richard G,Katz T

更新日期：2011-11-25 00:00:00

abstract：PURPOSE:To assess the reactive changes of the corneal epithelial thickness (ET) profile induced by small incision lenticule extraction (SMILE) for treatment of myopia. METHODS:This prospective observational study included 46 eyes of 23 patients that were scheduled for myopic SMILE. High-resolution spectral-domain opti...

journal_title：Investigative ophthalmology & visual science

authors： Luft N,Ring MH,Dirisamer M,Mursch-Edlmayr AS,Kreutzer TC,Pretzl J,Bolz M,Priglinger SG

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Homocysteine (Hcys), a well-known inducer of vascular endothelial cell damage has been associated with extracellular matrix changes. Lysyl oxidase (LOX) is a copper-dependent amine oxidase that initiates the covalent cross-linking of collagen and elastin in the extracellular matrix (ECM). LOX contributes to the...

journal_title：Investigative ophthalmology & visual science

authors： Coral K,Angayarkanni N,Gomathy N,Bharathselvi M,Pukhraj R,Rupak R

更新日期：2009-08-01 00:00:00

abstract：PURPOSE:Retinal blood vessel diameter and arteriovenous ratio (AVR) are commonly used diagnostic parameters. Because vascular walls are typically not visible in funduscopy, clinical AVR estimation is based on the lumen rather than the entire vessel diameter. Here the authors used a transgenic mouse model to quantify AV...

journal_title：Investigative ophthalmology & visual science

authors： Fischer MD,Huber G,Feng Y,Tanimoto N,Mühlfriedel R,Beck SC,Tröger E,Kernstock C,Preising MN,Lorenz B,Hammes HP,Seeliger MW

更新日期：2010-10-01 00:00:00

abstract：:The properties of the oscillatory potentials (OPs) of the mudpuppy electroretinogram (ERG) were studied and compared with the properties of the b-wave of the ERG and the proximal negative response (PNR). Both transretinal and intraretinal ERGs were recorded in response to full-field as well as 200 and 500 microgram sp...

journal_title：Investigative ophthalmology & visual science

authors： Wachtmeister L,Dowling JE

更新日期：1978-12-01 00:00:00

abstract：:Ocular sympathetic nerves were stimulated chronically in awake rabbits using electrodes unilaterally implanted on the cervical sympathetic trunk. IOP was measured by pneumatonometry and aqueous inflow was measured by fluorophotometry. In each animal, continuous trains of 1 msec pulses were delivered by means of a port...

journal_title：Investigative ophthalmology & visual science

authors： Belmonte C,Bartels SP,Liu JH,Neufeld AH

更新日期：1987-10-01 00:00:00

abstract：PURPOSE:Limited integration is consistently observed between subretinal transplants and host retinas. In the current study, an in vitro model system for studying connections forming between two abutting retinas was developed. METHODS:Neuroretinas were dissected from normal wild-type (WT) mice and green fluorescent pro...

journal_title：Investigative ophthalmology & visual science

authors： Zhang Y,Caffé AR,Azadi S,van Veen T,Ehinger B,Perez MT

更新日期：2003-11-01 00:00:00

abstract：:In order to induce stereoscopic depth, retinal images in the right and left eyes must differ. Our experiments demonstrate that these uniocular differences for simple three-line configurations at stereo-threshold cannot usually be distinguished one from the other. We confirm that depth values are associated with indivi...

journal_title：Investigative ophthalmology & visual science

authors： Westheimer G,McKee SP

更新日期：1979-06-01 00:00:00

abstract：PURPOSE:To evaluate the occurrence and time course of hem- and lymphangiogenesis after normal-risk corneal transplantation in the mouse model and to test whether pharmacologic strategies inhibiting both processes improve long-term graft survival. METHODS:Normal-risk allogeneic (C57BL/6 to BALB/c) and syngeneic (BALB/c...

journal_title：Investigative ophthalmology & visual science

authors： Cursiefen C,Cao J,Chen L,Liu Y,Maruyama K,Jackson D,Kruse FE,Wiegand SJ,Dana MR,Streilein JW

更新日期：2004-08-01 00:00:00

abstract：PURPOSE:High intraocular pressure (IOP) is a major risk factor for glaucoma, one of the leading causes of blindness worldwide. Because it has been demonstrated that African populations are at increased risk for glaucoma, the authors investigated the genetic basis of IOP in a sample of West Africans with type 2 diabetes...

journal_title：Investigative ophthalmology & visual science

authors： Rotimi CN,Chen G,Adeyemo AA,Jones LS,Agyenim-Boateng K,Eghan BA Jr,Zhou J,Doumatey A,Lashley K,Huang H,Fasanmade O,Akinsola FB,Ezepue F,Amoah A,Akafo S,Chen Y,Oli J,Johnson T

更新日期：2006-08-01 00:00:00

abstract：PURPOSE:The purpose of this study was to investigate the effect of bovine lactoferrin (BLF) on human corneal epithelial wound healing using an in vitro alkali-induced wound model and to understand its role in promoting wound healing. METHODS:Confluent human corneal limbal epithelial (HCLE) cells wounded using 0.5 micr...

journal_title：Investigative ophthalmology & visual science

authors： Pattamatta U,Willcox M,Stapleton F,Cole N,Garrett Q

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:This study sought to examine the acute effects of ocular ischemia and reperfusion on retinal function and determine the extent to which recovery during reperfusion is improved by allopurinol (AP), a blocker of xanthine oxidase (XO). The latter is presumed to be a major factor in the formation of free radicals a...

journal_title：Investigative ophthalmology & visual science

authors： Peachey NS,Green DJ,Ripps H

更新日期：1993-01-01 00:00:00