Renal effects of dual renin-angiotensin-aldosterone system blockade in patients with diabetic nephropathy.

Abstract:

:Evidence from recent studies indicates that in patients with diabetic nephropathy combined therapy with ACE inhibitors (ACEI) and AT1-receptor antagonists (ARB) results in more complete blockade of the renin-angiotensin-aldosterone system (RAS) than monotherapy, and reduces proteinuria. Most of these trials, however, had short follow-up, included a small number of patients, and were heterogeneous, so the opportunity to start this treatment in these patients remains unclear. This review summarizes the results of these studies, describing the renal effects of dual RAS blockade in both type 1 and type 2 diabetic patients.

journal_name

Int Urol Nephrol

authors

Dalla Vestra M,Simioni N,Masiero A

doi

10.1007/s11255-008-9490-0

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

119-26

issue

1

eissn

0301-1623

issn

1573-2584

journal_volume

41

pub_type

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