Digital-image analysis of the left common carotid artery in human foetuses.

Abstract:

:The rate of growth of the left common carotid artery during gestation has not been sufficiently evaluated. The present study was performed on 128 spontaneously aborted human foetuses aged 15-34 weeks to compile normative data for the dimensions of the left common carotid artery at varying gestational ages. Using anatomical dissection, digital image analysis (system of Leica Q Win Pro 16) and statistical analysis (ANOVA, regression analysis), a range of measurements (length, original external diameter and volume) for the left common carotid artery during gestation was examined. No significant gender differences were found (p > 0.05). The growth curves of the best fit for the plot of each morphometric parameter against gestational age were generated. The lengths ranged from 14.82 +/- 2.22 to 42.84 +/- 4.32 mm, according to the linear model y = -9.6918 + 1.5963 x +/- 3.1706 (r = 0.95; p < 0.001). The original external diameter increased from 0.72 +/- 0.18 to 3.28 +/- 0.40 mm, according to the linear function y = -1.5228 + 0.1428 x +/- 0.2749 (r = 0.95; p < 0.001). The left common carotid artery-to-aortic root diameter ratio increased from 0.356 +/- 0.062 to 0.480 +/- 0.101. The left common carotid artery-to-aortic arch diameter ratio increased from 0.447 +/- 0.079 to 0.535 +/- +/- 0.113. The volume ranged from 6.73 +/- 4.06 to 369.30 +/- 107.42 mm3 in accordance with the quadratic function y = 344.8 - 41.001 x + 1.254 x2 +/- +/- 46.955 (R2 = 0.87). The parameters examined have clinical application in the early recognition of arterial abnormalities, especially aortic coarctation.

journal_name

Folia Morphol (Warsz)

journal_title

Folia morphologica

authors

Szpinda M,Flisiński P,Wiśniewski M,Dombek M,Krakowiak-Sarnowska E

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

186-92

issue

3

eissn

0015-5659

issn

1644-3284

journal_volume

67

pub_type

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