Activation of JNK and PAK2 is essential for citrinin-induced apoptosis in a human osteoblast cell line.

abstract：:Acetaminophen (AP) is a widely used, cheap, and over-the-counter nonsteroidal anti-inflammatory drug. Its toxicity depends on the cytochrome P-450 (CYP)-mediated oxidation to the toxic metabolite N-acetyl-p-benzoquinoneimine. On the other hand, arsenic, a global groundwater and environmental contaminant of major publi...

journal_title：Environmental toxicology

authors： Manimaran A,Sarkar SN,Sankar P

更新日期：2011-06-01 00:00:00

abstract：:Petroleum products-petrol, kerosene, and diesel-composed of volatile organic constituents contribute to air pollution. Exposure of gas station attendants (GSAs) to petroleum products fumes (PPFs) may account for occupation-related predisposition to respiratory toxicity and disease pathogenesis. We simulated GSA exposu...

journal_title：Environmental toxicology

authors： Owumi SE,Elebiyo TC,Oladimeji BN

更新日期：2020-09-07 00:00:00

abstract：:Nickel oxide nanoparticles (nano NiO) could induce hepatocyte apoptosis, while its potential mechanisms are unclear. This study aimed to explore the role of endoplasmic reticulum (ER) stress pathways in hepatocyte apoptosis induced by nano NiO. Male Wistar rats were administrated with nano NiO (0.015, 0.06, and 0.24 m...

journal_title：Environmental toxicology

authors： Chang X,Liu F,Tian M,Zhao H,Han A,Sun Y

更新日期：2017-12-01 00:00:00

abstract：:Bisphenol AF (BPAF) has been shown to inhibit testicular steroidogenesis in male rats. However, the precise mechanisms related to the toxic effects of BPAF on reproduction remain poorly understood. In the present study, a mouse Leydig tumor cell line (mLTC-1) was used as a model to investigate the mechanism of steroid...

journal_title：Environmental toxicology

authors： Feng Y,Shi J,Jiao Z,Duan H,Shao B

更新日期：2018-06-01 00:00:00

abstract：:Smoking increases the risk of cardiovascular disorders and leads to damage caused by inflammation and oxidative stress. The actin cytoskeleton is a key player in the response to inflammatory stimuli and is an early target of cellular oxidative stress. The purpose of this study was to investigate the changes in actin c...

journal_title：Environmental toxicology

authors： Lin BH,Tsai MH,Lii CK,Wang TS

更新日期：2016-11-01 00:00:00

abstract：:PM10 was collected in a Milan urban site, representative of the city air quality, during winter and summer 2006. Mean daily PM10 concentration was 48 μg m(-3) during summer and 148 μg m(-3) during winter. Particles collected on Teflon filters were chemically characterized and the endotoxin content determined by the ...

journal_title：Environmental toxicology

authors： Camatini M,Corvaja V,Pezzolato E,Mantecca P,Gualtieri M

更新日期：2012-02-01 00:00:00

abstract：:Environmental stress factors may be responsible for biological changes in living species that are able to overcome deleterious effects depending on their detoxifying capacities. Defense systems present in every living species are involved in elimination of reactive chemical species of endogenous or exogenous origin, n...

journal_title：Environmental toxicology

authors： Vasseur P,Leguille C

更新日期：2004-08-01 00:00:00

abstract：:Toxicity of lead on male reproductive functions has raised wide public concern as environmental lead contamination remains common worldwide. Conflicting and controversial data are available regarding effects of lead on male fertility. More importantly, our knowledge on effects of lead on sperm DNA integrity is signifi...

journal_title：Environmental toxicology

authors： Li C,Zhao K,Zhang H,Liu L,Xiong F,Wang K,Chen B

更新日期：2018-05-01 00:00:00

abstract：:The aim of this study was to evaluate whether the enzyme-linked immunosorbent assay (ELISA) anti-Adda technique could be used to monitor free microcystins (MCs) in biological samples from fish naturally exposed to toxic cyanobacteria by using receiver operating characteristic (ROC) curve software to establish an optim...

journal_title：Environmental toxicology

authors： Moreno IM,Herrador MÁ,Atencio L,Puerto M,González AG,Cameán AM

更新日期：2011-02-01 00:00:00

abstract：:The use of malachite green (MG) in fish farming is prohibited in China due to its potentially toxicological and carcinogenic nature, but it is still illegally used in some places. The aim of this study was to investigate the time and concentration-dependent responses of xenobiotic metabolizing and detoxification-relat...

journal_title：Environmental toxicology

authors： Li G,Shen D,Liang XF,He Y,He S

更新日期：2013-03-01 00:00:00

abstract：:In recent years cyanobacteria blooms have become a severe problem in Taihu Lake, a large shallow eutrophic lake in China. Microcystins produced by certain genera of cyanobacteria can affect public health in this area because of their acute and chronic toxic effects. In this study, samples of cyanobacteria were collect...

journal_title：Environmental toxicology

authors： Wu JY,Xu QJ,Gao G,Shen JH

更新日期：2006-06-01 00:00:00

abstract：:Oral cancer is one of the cancer-related diseases in human populations and its incidence rates are rising worldwide. Fisetin, a flavonoid from natural products, has been shown to exhibit anticancer activities in many human cancer cell lines but the molecular mechanism of fisetin-induced apoptosis in human oral cancer ...

journal_title：Environmental toxicology

authors： Su CH,Kuo CL,Lu KW,Yu FS,Ma YS,Yang JL,Chu YL,Chueh FS,Liu KC,Chung JG

更新日期：2017-06-01 00:00:00

abstract：:Ecological risk assessments are, in part, based on results of toxicity tests conducted under standard exposure conditions. Global climate change will have a wide range of effects on estuarine habitats, including potentially increasing water temperature and salinity, which may alter the risk assessment of estuarine pol...

journal_title：Environmental toxicology

authors： DeLorenzo ME,Danese LE,Baird TD

更新日期：2013-07-01 00:00:00

abstract：:There is emerging evidence suggesting that oxidative stress and DNA methylation can alter miRNA expression. However, little is known on the mechanism of miR-17-5p expression changes in paraquat (PQ)-induced nerve cell damage. In the present study, neuro-2a cells were pretreated with antioxidant N-acetylcysteine (NAC) ...

journal_title：Environmental toxicology

authors： Zhan Y,Guo Z,Zheng F,Zhang Z,Li K,Wang Q,Wang L,Cai Z,Chen N,Wu S,Li H

更新日期：2020-12-01 00:00:00

abstract：:The correlation between the content of three microcystins (types LR, RR and YR) and the cell cycle of an axenic strain of Microcystis viridis, NIES-102, was investigated under conditions of high (16 mg L(-1)) and low (1.0 mg L(-1)) nitrate (NO(3)-N) concentrations. Each phase of the cell cycle was identified using a f...

journal_title：Environmental toxicology

authors： Kameyama K,Sugiura N,Inamori Y,Maekawa T

更新日期：2004-02-01 00:00:00

abstract：:Irradiation of polycyclic aromatic hydrocarbons (PAHs) in aqueous solution with simulated solar radiation (SSR; a light source with a visible light: UV-A:UV-B ratio similar to that of sunlight) can greatly enhance their toxicity. Two microbial toxicity tests with Vibrio fischeri were used to investigate the effect of ...

journal_title：Environmental toxicology

authors： el-Alawi YS,Dixon DG,Greenberg BM

更新日期：2001-06-01 00:00:00

abstract：:Three methods of algal assays--the standard assay, microassay, and the proposed fluorescence assay--are compared from the point of view of reliability of EC50 detection, the minimum required time for the detection, sensitivity of individual measurement, i.e. at which cell density the particular assay can be used for E...

journal_title：Environmental toxicology

authors： Kvíderová J

更新日期：2010-12-01 00:00:00

abstract：:Widespread occupational and environmental exposure to benzene is unavoidable and poses a public health threat. Studies of potential interventions to prevent or relieve benzene toxicity are, thus, essential. Research has shown l-carnitine (LC) has beneficial effects against various pathological processes and diseases. ...

journal_title：Environmental toxicology

authors： Sun R,Man Z,Ji J,Ji S,Xu K,Pu Y,Yu L,Zhang J,Yin L,Pu Y

更新日期：2020-10-01 00:00:00

abstract：:Methoxychlor (MXC), an organochloride insecticide, is a potent toxicant-targeting female reproductive system and known to cause follicular atresia by inducing apoptosis within granulosa cells. Oxidative stress plays a pivotal role in apoptosis; thus, this study focuses on the ameliorative action of N-acetyl cysteine (...

journal_title：Environmental toxicology

authors： Bhardwaj JK,Saraf P

更新日期：2017-01-01 00:00:00

abstract：:Methyl tert-butyl ether (MTBE) is a gasoline oxygenate and antiknock additive substituting for lead alkyls currently in use worldwide. Previous studies have shown that MTBE at very high doses induces tumors in rodents. The aim of the present study was to examine directly the binding ability of MTBE onto DNA, demonstra...

journal_title：Environmental toxicology

authors： Du HF,Xu LH,Wang HF,Liu YF,Tang XY,Liu KX,Peng SX

更新日期：2005-08-01 00:00:00

abstract：:7,12-Dimethylbenz[α]anthracene (DMBA) is a hazardous component present in polluted environments. DMBA has been used as an experimental tool for in vivo tumor formation owing to its carcinogenic effects, but the detailed molecular mechanism of DMBA has not been fully established. To comprehend the carcinogenic mechanis...

journal_title：Environmental toxicology

authors： Kwon YJ,Ye DJ,Baek HS,Chun YJ

更新日期：2018-07-01 00:00:00

abstract：:The sensitivities of juvenile and adult amphipods to metals (Cd, Cu, Ni, Pb, and Zn) in whole sediment and water-only exposures were compared using a newly developed acute test with the estuarine species Melita plumulosa. Endpoints included survival and bioaccumulation in adults, and survival and growth (body length) ...

journal_title：Environmental toxicology

authors： King CK,Gale SA,Stauber JL

更新日期：2006-10-01 00:00:00

abstract：:We hypothesized that chronic exposure to arsenic would deplete the reduced glutathione (GSH) and methionine in vivo, thereby impair the methylation capacity of inorganic arsenic (iAs) ingested. Our experiment was designed to explore the effects of exogenous GSH and methionine on arsenic methylation in mice exposed to ...

journal_title：Environmental toxicology

authors： Jin Y,Zhao F,Zhong Y,Yu X,Sun D,Liao Y,Lv X,Li G,Sun G

更新日期：2010-08-01 00:00:00

abstract：:Although marine and coastal environments which are contaminated with xenobiotic organic compounds often become hypoxic during the summer, the interactive effects of hypoxia and xenobiotic exposure on marine species such as teleost fishes remain poorly understood. The expression and activity of monooxygenase enzyme cyt...

journal_title：Environmental toxicology

authors： Rahman MS,Thomas P

更新日期：2018-04-01 00:00:00

abstract：:A high throughput culture methodology of unicellular eukaryote Tetrahymena pyriformis, strain GL were used for the determination of catecholamines toxicity and their metabolism. Catecholamines exhibited acute toxicity to Tetrahymena cells where dopamine and L-DOPA showed higher toxic potential of EC(10) (0.39 and 0.63...

journal_title：Environmental toxicology

authors： Ud-Daula A,Pfister G,Schramm KW

更新日期：2009-12-01 00:00:00

abstract：:Increasing use of pesticides all over the world makes it necessary to reveal the toxic risk in populations of nontargeted organisms. Bendiocarb is one of the 12 insecticides recommended by the World Health Organization for use in malaria control in Africa, and is used against a variety of insects. The liver has an imp...

journal_title：Environmental toxicology

authors： Petrovova E,Purzyc H,Mazensky D,Luptakova L,Torma N,Sopoliga I,Sedmera D

更新日期：2015-02-01 00:00:00

abstract：:Alpha-cypermethrin (α-CYP) is one of the most widely used insecticides. It may become an air pollutant and adversely affect the health. The present study was designed to determine whether treatment with N-acetyl cysteine (NAC), a well-known antioxidant, can be useful for the management of the deleterious effects of α-...

journal_title：Environmental toxicology

authors： Arafa MH,Mohamed DA,Atteia HH

更新日期：2015-01-01 00:00:00

abstract：:The acute toxicity of the insecticide fenitrothion was measured using four freshwater algae (Chlorella saccharophila, Chlorella vulgaris, Scenedesmus acutus, and Scenedesmus subspicatus) and one cyanobacteria (Pseudanabaena galeata). Insecticide concentrations eliciting 50% growth reduction over 96 hr (EC50) ranged fr...

journal_title：Environmental toxicology

authors： Sabater C,Carrasco JM

更新日期：2001-01-01 00:00:00

abstract：:Sulfur dioxide (SO2 ) is a ubiquitous air pollutant. The previous studies have documented the adverse effects of SO2 on nervous system health, suggesting that acutely SO2 inhalation at high concentration may be associated with neurotoxicity and increase risk of hospitalization and mortality of many brain disorders. Ho...

journal_title：Environmental toxicology

authors： Yao G,Yun Y,Sang N

更新日期：2016-07-01 00:00:00

abstract：:Titanium dioxide nanoparticles (TiO2 NPs) have been used in environmental management, food, medicine, and industry. But TiO2 NPs have been demonstrated to cross the blood-brain barrier and store up in the brain organization, leading to glutamate-mediated neurotoxicity. However, the neurotoxicity in the brain is not we...

journal_title：Environmental toxicology

authors： Ze X,Su M,Zhao X,Jiang H,Hong J,Yu X,Liu D,Xu B,Sheng L,Zhou Q,Zhou J,Cui J,Li K,Wang L,Ze Y,Hong F

更新日期：2016-06-01 00:00:00