Dopamine acting through D2 receptors modulates the expression of PSA-NCAM, a molecule related to neuronal structural plasticity, in the medial prefrontal cortex of adult rats.

abstract：:Infant rats were subjected to pentylenetetrazol-induced convulsions on alternate days from 5 to 13 days of age. At 17 days of age, their susceptibility to the convulsant effects of hyperthermia was examined. It was found that previous pentylenetetrazol-induced convulsions caused a significant facilitation in the devel...

journal_title：Experimental neurology

authors： McCaughran JA Jr,Manetto C

更新日期：1983-01-01 00:00:00

abstract：:Axons of retinal ganglion cells (RGCs) of adult cats were transected and regenerated by the transplantation of peripheral nerves. Two months after transplantation dendritic arbors of RGCs with regenerated axons (r-RGCs) were visualized with intracellular injections of horseradish peroxidase (HRP). The HRP-filled r-RGC...

journal_title：Experimental neurology

authors： Watanabe M,Fukuda Y

更新日期：1997-01-01 00:00:00

abstract：:Chronically axotomized motoneurons progressively fail to regenerate their axons. Since axonal regeneration is associated with the increased expression of tubulin, actin and GAP-43, we examined whether the regenerative failure is due to failure of chronically axotomized motoneurons to express and sustain the expression...

journal_title：Experimental neurology

authors： Gordon T,You S,Cassar SL,Tetzlaff W

更新日期：2015-02-01 00:00:00

abstract：:The behavioral effects of augmenting dopamine D1 receptor expression in the brain were investigated in mice incorporating additional copies of the mouse D1 receptor gene. Two transgenic lines showed increases in brain D1 receptor binding sites, which were greatest in extrastriatal regions. The full D1 agonist SKF 8129...

journal_title：Experimental neurology

authors： Dracheva S,Xu M,Kelley KA,Haroutunian V,Holstein GR,Haun S,Silverstein JH,Sealfon SC

更新日期：1999-05-01 00:00:00

abstract：AIMS/HYPOTHESIS:Dorsal root ganglia (DRG) sensory neurons cultured from 3 to 5 month streptozotocin (STZ)-induced diabetic rats exhibit structural and biochemical changes seen in peripheral nerve fibers in vivo, including axonal swellings, oxidative damage, reduced axonal sprouting, and decreased NF-κB activity. NF-κB ...

journal_title：Experimental neurology

authors： Saleh A,Schapansky J,Smith DR,Young N,Odero GL,Aulston B,Fernyhough P,Glazner GW

更新日期：2013-03-01 00:00:00

abstract：:Recent evidence indicates that protein aggregation and in particular the formation of toxic protein oligomers is a key mechanism in synucleinopathies such as Parkinson's disease (PD). Post mortem brain tissue studies as well as animal studies furthermore suggest that matrix metalloproteinases (MMPs) are also involved ...

journal_title：Experimental neurology

authors： Levin J,Giese A,Boetzel K,Israel L,Högen T,Nübling G,Kretzschmar H,Lorenzl S

更新日期：2009-01-01 00:00:00

abstract：:There is evidence to suggest that the reticular activating system may have an influence on the neurons of the preoptic area (POA). We studied the responses of POA neurons and their relation to the cortical EEG, on stimulation of the midbrain reticular formation (MRF) at various frequencies, in unanesthetized, encéphal...

journal_title：Experimental neurology

authors： Mohan Kumar V,Mallick BN,Chhina GS,Singh B

更新日期：1984-10-01 00:00:00

abstract：:We report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited ...

journal_title：Experimental neurology

authors： Eickhoff SB,Dafotakis M,Grefkes C,Stöcker T,Shah NJ,Schnitzler A,Zilles K,Siebler M

更新日期：2008-12-01 00:00:00

abstract：:Intracranial collaterals provide residual blood flow to penumbral tissue in acute ischemic stroke and contribute to infarct size variability in humans. In the present study, hemodynamic monitoring of the borderzone territory between the leptomeningeal branches of middle cerebral artery and anterior cerebral artery was...

journal_title：Experimental neurology

authors： Riva M,Pappadà GB,Papadakis M,Cuccione E,Carone D,Menendez VR,Sganzerla EP,Beretta S

更新日期：2012-02-01 00:00:00

abstract：:Human recombinant activated factor-VII (rFVIIa) has been used successfully in the treatment of spontaneous intracerebral hemorrhage. In addition, there is increasing interest in its use to treat uncontrolled bleeding of other origins, including trauma. The aim of this study was to evaluate the safety and potential eff...

journal_title：Experimental neurology

authors： Zhang J,Groff RF 4th,Chen XH,Browne KD,Huang J,Schwartz ED,Meaney DF,Johnson VE,Stein SC,Rojkjaer R,Smith DH

更新日期：2008-04-01 00:00:00

abstract：:Aberrant accumulation of neurofilaments is a feature of human motor neuron diseases. Experimentally motor neuron disease can be induced in transgenic mice by overexpressing the mouse neurofilament light subunit (NF-L), the human heavy subunit (NF-H), or mouse peripherin. Here we describe that mice harboring a bacteria...

journal_title：Experimental neurology

authors： Gama Sosa MA,Friedrich VL Jr,DeGasperi R,Kelley K,Wen PH,Senturk E,Lazzarini RA,Elder GA

更新日期：2003-11-01 00:00:00

abstract：:Bombesin/gastrin-releasing peptide (BB/GRP) receptors were characterized in fetal cortex transplants in the rat. Using in vitro autoradiography techniques, the density of (125I-Tyr4)BB grains was low 2 weeks after transplantation but increased 4 weeks after cortex transplantation into the adult rat fourth ventricle. D...

journal_title：Experimental neurology

authors： Moody TW,Getz R,Rosenstein JM

更新日期：1996-11-01 00:00:00

abstract：:The left external auditory meatus was removed in 4-day-old CBA/J mice; after killing at 45 days, serial sections of the cochleae and brain stem were prepared. From these, the cross-sectional areas of spiral ganglion neurons and of 14 auditory brain stem neuronal types were measured, using a total of 210 neurons of eac...

journal_title：Experimental neurology

authors： Webster DB

更新日期：1983-01-01 00:00:00

abstract：:There is a consensus that active sleep (AS; i.e., REM sleep) is produced by cholinergic projections from the pedunculopontine tegmental nuclei (PPT) that activate AS-on neurons in the nucleus pontis oralis (NPO) that are components of the AS-Generator. However, there is a growing body of evidence indicating that other...

journal_title：Experimental neurology

authors： Xi M,Fung SJ,Zhang J,Sampogna S,Chase MH

更新日期：2012-11-01 00:00:00

abstract：:Breathing is a vital homeostatic behavior and must be precisely regulated throughout life. Clinical conditions commonly associated with inflammation, undermine respiratory function may involve plasticity in respiratory control circuits to compensate and maintain adequate ventilation. Alternatively, other clinical cond...

journal_title：Experimental neurology

authors： Hocker AD,Stokes JA,Powell FL,Huxtable AG

更新日期：2017-01-01 00:00:00

abstract：:Embryonic substantia nigra grafts partially reinnervate the dopamine-denervated corpus striatum when implanted adjacent to that structure. This reinnervation is generally limited to a small portion of the denervated striatum and does not completely compensate for the behavioral effects of a 6-hydroxydopamine lesion of...

journal_title：Experimental neurology

authors： de Beaurepaire R,Freed WJ

更新日期：1987-02-01 00:00:00

abstract：:Grafts of embryonic ventral mesencephalic tissue placed in the striatum of 6-hydroxydopamine-lesioned rats survive, and make and receive connections to and from the host brain. The dopaminergic neurons of the graft can grow processes into the host brain, and thereby alleviate many of the behavioral deficits of this fo...

journal_title：Experimental neurology

authors： Barker RA,Dunnett SB,Faissner A,Fawcett JW

更新日期：1996-09-01 00:00:00

abstract：:Neuropathological studies of human traumatic brain injury (TBI) cases have described amyloid plaques acutely after a single severe TBI, and tau pathology after repeat mild TBI (mTBI). This has helped drive the hypothesis that a single moderate to severe TBI increases the risk of developing late-onset Alzheimer's disea...

journal_title：Experimental neurology

authors： Washington PM,Villapol S,Burns MP

更新日期：2016-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis [ALS] is a rapidly progressive neurodegenerative disorder of motor neurons, heralded by the development of cortical hyperexcitability. Reduction of short interval intracortical inhibition [SICI] in ALS, a feature linked to the development of cortical hyperexcitability, may be mediated by ...

journal_title：Experimental neurology

authors： Vucic S,Cheah BC,Kiernan MC

更新日期：2009-11-01 00:00:00

abstract：:Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that are widely expressed throughout the developing and adult CNS. In vitro studies demonstrate their potential to restrict neurite outgrowth, and it is believed that CSPGs also inhibit axonal regeneration after CNS injury in vivo. Prev...

journal_title：Experimental neurology

authors： Jones LL,Margolis RU,Tuszynski MH

更新日期：2003-08-01 00:00:00

abstract：:Adrenergic-stimulated phosphatidylinositol (PI) hydrolysis was measured in cortical slices obtained from adult rats following electroconvulsive seizures (ECS). One group of animals received ECS daily for 15 days and a second group received a single ECS. Rats were then sacrificed at intervals of 15 min, 60 min, 4 h, an...

journal_title：Experimental neurology

authors： Dubeau F,Sherwin AL

更新日期：1989-08-01 00:00:00

abstract：:This study was undertaken as part of the NIH "Facilities of Research-Spinal Cord Injury" project to support independent replication of published studies. Here, we repeated a study reporting that a combinatorial treatment with transplants of Schwann cells, systemic delivery of Rolipram to enhance cyclic AMP levels, and...

journal_title：Experimental neurology

authors： Sharp KG,Flanagan LA,Yee KM,Steward O

更新日期：2012-02-01 00:00:00

abstract：:Neuronal activity in the locus ceruleus of awake, behaving stump-tailed monkeys increased consistently and vigorously after presentation of mildly aversive and threatening stimuli. These preliminary data increase the range of stimuli reported to elicit locus ceruleus activity in awake monkeys to include nonpainful thr...

journal_title：Experimental neurology

authors： Grant SJ,Redmond DE Jr

更新日期：1984-06-01 00:00:00

abstract：:Discovery of new central nervous system (CNS) acting therapeutics has been slowed down by the lack of useful applicable biomarkers of disease or drug action often due to inaccessibility of relevant human CNS tissue and cell types. In recent years, non-neuronal cells, such as astrocytes, have been reported to play a hi...

journal_title：Experimental neurology

authors： Sattler R,Ayukawa Y,Coddington L,Sawa A,Block D,Chipkin R,Rothstein JD

更新日期：2011-12-01 00:00:00

abstract：:A 168-nucleotide exon, found in alternatively spliced amyloid precursor protein (APP) mRNAs, encodes a Kunitz protease inhibitor (KPI) domain. Kainic acid (ip) caused a selective increase of KPI mRNA in rat hippocampus. By in situ hybridization, KPI mRNA was induced in the neuronal layers of the hippocampus 11-12 h af...

journal_title：Experimental neurology

authors： Willoughby DA,Johnson SA,Pasinetti GM,Tocco G,Najm I,Baudry M,Finch CE

更新日期：1992-12-01 00:00:00

abstract：:Thyroid hormones and spermidine, a motor neuron trophic polyamine (PA), have been shown to enhance peripheral motor nerve regeneration; however, the mechanism by which these treatment modalities exert their effect is unknown. Similarities in treatment outcome suggest that these molecules may be working via a common me...

journal_title：Experimental neurology

authors： Oble DA,Burton L,Maxwell K,Hassard T,Nathaniel EJ

更新日期：2004-09-01 00:00:00

abstract：:The blood-brain barrier function and the vasomotor response in rat microcirculation was studied using a closed cranial window technique and an intravital fluorescence microscope with an attempt to reduce both the light intensity and the amount of 2% Na(+)-fluorescein to as little as possible. The light intensities in ...

journal_title：Experimental neurology

authors： Kawamura S,Yasui N

更新日期：1992-09-01 00:00:00

abstract：:Peripheral nerve regeneration was studied across a tubulated 10-mm gap in the rat sciatic nerve using histomorphometry and electrophysiological measurements of A-fiber, B-fiber, and C-fiber peaks of the evoked action potentials. Tubes fabricated from large-pore collagen (max. pore diameter, 22 nm), small-pore collagen...

journal_title：Experimental neurology

authors： Chamberlain LJ,Yannas IV,Hsu HP,Strichartz G,Spector M

更新日期：1998-12-01 00:00:00

abstract：:Extracellular single-unit responses of neurons in the ipsilateral pulvinar-lateral posterior complex were recorded in 10 encéphale isolé cats with stimulating electrodes implanted in the substantia nigra pars reticulata and pars lateralis. Fifteen percent of 101 pulvinar-lateral posterior complex thalamic neurons incr...

journal_title：Experimental neurology

authors： Infante C,Leiva J,Motles E,Saavedra H

更新日期：1988-02-01 00:00:00

abstract：:Both fresh and cryopreserved-thawed human fetal ventral mesencephalon have been used for preclinical research and implantation into the brains of patients with Parkinson's disease. Further characterization and an evaluation of the effects of cryopreservation on immunocytochemical and neurochemical markers of monoamine...

journal_title：Experimental neurology

authors： Kontur PJ,Leranth C,Redmond DE Jr,Roth RH,Robbins RJ

更新日期：1993-06-01 00:00:00