Abstract:
:Micro-organisms constantly invade the human body and may form a threat to our health. Traditionally, concepts of defence mechanisms have included a protective outer layer of epithelia and a vigilant immune system searching for areas where the integrity of the outer layer may be compromised. Instead of considering these elements as two independent mechanisms, we should be treating them as a single integrated system. This review will present and discuss the role of local immune-competent cells and local epithelia in the recognition of potential pathogens and how the interaction between the two components may affect the initiation of the airway immune response. A concept emerges where airway mucosal dendritic cells act as integrators of both immunostimulatory and immunosuppressive signals that act within actively-involved mucosal tissue.
journal_name
Allergyjournal_title
Allergyauthors
van Tongeren J,Reinartz SM,Fokkens WJ,de Jong EC,van Drunen CMdoi
10.1111/j.1398-9995.2008.01791.xsubject
Has Abstractpub_date
2008-09-01 00:00:00pages
1124-35issue
9eissn
0105-4538issn
1398-9995pii
ALL1791journal_volume
63pub_type
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