[Fractalkine--a proinflammatory chemokine in rheumatoid arthritis].

abstract：:Osteoporosis is defined by decreased bone strength and increased susceptibility to fracture. Fractures and their consequences are the clinical manifestation of osteoporosis. Acute and chronic pain, functional limitations including permanent impairment and the need for long-term care may be caused by osteoporotic fract...

journal_title：Zeitschrift fur Rheumatologie

authors： Preisinger E

更新日期：2009-09-01 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis is found in approximately 2 % of the total population in Europe and the peak incidence of the disease is during the fourth and fifth decades of life. In approximately 15 % the first symptoms of the disease occur at the level of the foot and ankle. If the early stage-dependent therapy wit...

journal_title：Zeitschrift fur Rheumatologie

authors： Thomas M,Jordan M

更新日期：2014-11-01 00:00:00

abstract：:In order to measure therapeutic effects or assess disease course, outcomes measurement parameters are commonly used in patients with rheumatoid arthritis. From the patient's perspective, possibly the most important outcome measurement parameter is quality of life (QoL). QoL may be defined in terms of "health status" a...

journal_title：Zeitschrift fur Rheumatologie

authors： Stamm T

更新日期：2010-05-01 00:00:00

abstract：:Personalized healthcare tries to predict the effectiveness and safety in individual therapeutic approaches by defining individual patient characteristics (biomarkers), while stratification uses diagnostic patterns for groups of patients for prediction of therapeutic response with less adverse reactions caused by the d...

journal_title：Zeitschrift fur Rheumatologie

authors： Behrens F,Köhm M

更新日期：2013-02-01 00:00:00

abstract：:Superficial heat and cold are commonly used therapeutic methods in patients with rheumatoid arthritis. Both procedures have analgesic effect. In 30 inpatients with rheumatoid arthritis the pain threshold was measured before and after warm bath and ice massage. Rheumatoid patients had significantly lower pain threshold...

journal_title：Zeitschrift fur Rheumatologie

authors： Curković B,Vitulić V,Babić-Naglić D,Dürrigl T

更新日期：1993-09-01 00:00:00

abstract：:Low back pain (LBP) in patients with rheumatoid arthritis (RA) has so far been of little concern in clinical investigations. The main focus of scientific publications on spinal problems in RA was the cervical spine. In a recent study, we could demonstrate that LBP in RA patients leads to a significantly higher degree ...

journal_title：Zeitschrift fur Rheumatologie

authors： Kothe R

更新日期：2017-12-01 00:00:00

abstract：:Inflammation-mediated osteopenia is an animal model for bone mass reduction following chronic inflammation. We found a reduction of calcitriol serum concentrations during the inflammatory process, in addition cytokines are increased. Treatment of the animals with calcitriol is able to prevent bone mass reduction and t...

journal_title：Zeitschrift fur Rheumatologie

authors： Scharla SH,Lempert UG,Kamilli I

更新日期：2000-01-01 00:00:00

abstract：:The antidesoxyribonuclease B reaction shows in persons of all classes of age examined a similar distribution of titres as the antistreptolysin reaction. The anti DNase B titres however are mostly lower than the titres of the antistreptolysin reaction, except in the group of children, 6 to 17 years of age, suffering fr...

journal_title：Zeitschrift fur Rheumatologie

authors： Otto R,Richter M,Scholz E,Neumann G

更新日期：1981-01-01 00:00:00

abstract：:Patient education is a medical intervention for patients with chronic diseases to increase knowledge of their disease, self-efficacy, self-management and consumer behaviour. The goal is to improve their disease outcome, social participation and quality of life. This article reviews concepts, modalities and knowledge o...

journal_title：Zeitschrift fur Rheumatologie

authors： Genth E

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:Reliable data on the course and treatment of pediatric COVID-19 ("corona virus disease 2019") in immunosuppressed patients with rheumatic diseases are missing. AIM:Delineation of individual strategies of the members of the Society for Pediatric Rheumatology (GKJR) in cases of COVID-19. METHODS:In May 2020 ...

journal_title：Zeitschrift fur Rheumatologie

authors： Janda A,Schuetz C,Heeg M,Minden K,Hedrich CM,Kallinich T,Hinze C,Schulz A,Speth F

更新日期：2020-09-01 00:00:00

abstract：:42 patients with definite or classic rheumatoid arthritis were treated with an enzyme mixture (Wobenzym) for 6 weeks. Circulating immune complexes were investigated with a Clq-solid phase RIA in weekly intervals and also rheumatoid factors were determined together with other routine laboratory tests. The condition of ...

journal_title：Zeitschrift fur Rheumatologie

authors： Steffen C,Smolen J,Miehlke K,Hörger I,Menzel J

更新日期：1985-03-01 00:00:00

abstract：:Health services research in rheumatology investigates the healthcare needs, the quality of care and trends in healthcare for patients with musculoskeletal disorders. Using rheumatoid arthritis (RA) as an example, key results of health services research during the last 25 years are summarized. There are currently appro...

journal_title：Zeitschrift fur Rheumatologie

authors： Zink A

更新日期：2014-03-01 00:00:00

abstract：:The immune system is regulated by a variety of mechanisms that prevent overwhelming immune responses and a break in tolerance. There have been indications for some time that populations of B cells are also a part of this network and able to exert regulatory functions. Here we summarize current knowledge on this previo...

journal_title：Zeitschrift fur Rheumatologie

authors： Tretter T,Lorenz HM

更新日期：2010-11-01 00:00:00

abstract：:Inflammatory rheumatic diseases often affect females of childbearing age and pregnancy remains a challenge for this group of patients and their physicians. However, the majority of patients can now have successful pregnancies and deliver healthy babies as a result of our improved knowledge of the risks encountered dur...

journal_title：Zeitschrift fur Rheumatologie

authors： Fischer-Betz R,Gromnica-Ihle E

更新日期：2010-09-01 00:00:00

abstract：:Systemic sclerosis (SSc) is a polymorphic and heterogenic systemic disorder with inflammation, fibrosis and vascular damage. Early diagnosis and classification may be difficult if disease expression is oligosymptomatic (undifferentiated), presenting with only Raynaud's phenomenon or limited scleroderma. Scleroderma sp...

journal_title：Zeitschrift fur Rheumatologie

authors： Genth E,Krieg T

更新日期：2006-07-01 00:00:00

abstract：:Biochemical studies of rats with mycoplasma arthritis revealed new findings in pathogenesis and pathophysiology. Preliminary examinations showed that mycoplasmas release specific endonucleases and exonucleases. In evaluating the isoenzymes of the lactate dehydrogenases, malate dehydrogenases as well as of the esterase...

journal_title：Zeitschrift fur Rheumatologie

authors： Klein G

更新日期：1975-05-01 00:00:00

abstract：:The nephrotoxicity of methotrexate (MTX) is a phenomenon which is observed in high-dose therapy for treatment of malignant diseases. Even low-dose MTX therapy for treatment of rheumatic diseases is claimed to cause impairment in renal function. The necessity to adapt the dosage of MTX therapy for renal function disord...

journal_title：Zeitschrift fur Rheumatologie

authors： Fiehn C

更新日期：2011-12-01 00:00:00

abstract：:In general, the risk of serious infections increases with age, mainly explained by immunosenescence and accumulation of comorbidities. Those patients with rheumatoid arthritis who are of advanced age and require treatment with immunosuppressive agents are at particular risk to develop an infectious disease. Actual req...

journal_title：Zeitschrift fur Rheumatologie

authors： Kneitz C,Strangfeld A,Krüger K

更新日期：2014-04-01 00:00:00

abstract：:Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) require a differentiated therapeutic approach depending on the degree of organ dysfunction and disease activity. In organ dysfunction and life-threatening AAV cyclophosphamide and rituximab are recommended for the induction of remission. For remi...

journal_title：Zeitschrift fur Rheumatologie

authors： Schinke S,Riemekasten G,Lamprecht P

更新日期：2017-02-01 00:00:00

abstract：:Up to now stratified therapy concepts have not played an important role in the treatment of patients with rheumatoid arthritis; however, a high heterogeneity regarding the effectiveness of therapies and occurrence of side effects in patients with the same indications provokes research efforts aiming at identifying and...

journal_title：Zeitschrift fur Rheumatologie

authors： Frank M,Mittendorf T

更新日期：2013-02-01 00:00:00

abstract：:Cell-based therapeutical approaches are already in clinical use and are attracting growing interest for the treatment of joint defects. Mesenchymal stem and precursor cells (MSC) cover a wide range of properties that are useful for the regeneration process of bone and cartilage defects. The following article is an ove...

journal_title：Zeitschrift fur Rheumatologie

authors： Dehne T,Tschirschmann M,Lauster R,Sittinger M

更新日期：2009-05-01 00:00:00

abstract：:Ocular manifestations of systemic vasculitides are extraordinarily pleomorph and have been described for many decades. In the introduction the special interaction of the immune system and the eye is outlined. Thereafter diagnostic procedures of patients suffering from systemic vasculitides are shown from an ophthalmol...

journal_title：Zeitschrift fur Rheumatologie

authors： Nölle B

更新日期：2001-08-01 00:00:00

abstract：:Certolizumab pegol is a new anti-TNF-alpha inhibitor which has been approved for the treatment of rheumatoid arthritis since October 2009. Due to the modification of the antibody fragment by the adherence of polyethylene glycol (PEG) a sufficient distribution in inflammatory tissue was found in animal experiments. In ...

journal_title：Zeitschrift fur Rheumatologie

authors： Schmeiser T,Müller-Ladner U

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:To assess the relative efficacy and safety of apremilast, secukinumab, and ustekinumab at different doses in patients with active psoriatic arthritis (PsA). METHOD:A Bayesian network meta-analysis was conducted, which included randomized controlled trials (RCTs) that examined the efficacy and safety of aprem...

journal_title：Zeitschrift fur Rheumatologie

authors： Song GG,Lee YH

更新日期：2018-09-01 00:00:00

abstract：:The modified significance of radiological criterion in the new ACR/EULAR classification criteria for rheumatoid arthritis is based on the fact that the bone erosion seen using conventional radiology is the result of an already longstanding inflammatory process.In contrast, new imaging modalities such as magnetic reson...

journal_title：Zeitschrift fur Rheumatologie

authors： Strunk J

更新日期：2011-04-01 00:00:00

abstract：:Heberden nodes affect mainly middle-aged women. Inheritance is autosomal dominant in female and autosomal recessive in male patients. We report the case of a young man who presented already with 12 years of age with pain in the distal finger joints. There were no other clinical or serological signs for other rheumatoi...

journal_title：Zeitschrift fur Rheumatologie

authors： Rascu A,Kraetsch HG,Grünke M,Kalden JR,Manger B

更新日期：1999-04-01 00:00:00

abstract：:Three new findings are reviewed that help to understand the mechanisms of action of anti-rheumatic gold drugs, such as disodium aurothiomalate (Na2Au(I)TM): i) We found that Na2Au(I)TM selectively inhibits T-cell receptor-mediated antigen recognition by murine CD4+ T-cell hybridomas specific for antigenic peptides con...

journal_title：Zeitschrift fur Rheumatologie

authors： Griem P,Gleichmann E

更新日期：1996-09-01 00:00:00

abstract：INTRODUCTION:Data with respect to safety and therapeutic efficacy for the combination of biological DMARDs is scarce and inhomogeneous in order to make final conclusions. To this end, data to biologic combinations is disappointing due to relatively low therapeutic efficacy and partially enhanced rates of severe infecti...

journal_title：Zeitschrift fur Rheumatologie

authors： Härle P

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:Early detection of patients with axial spondylarthritis (axSpA) in primary care is difficult. The combination of various parameters indicative of inflammatory back pain (AWARE criteria) was found to be beneficial in an initial study. OBJECTIVE:Review of the criteria for the identification of young patients ...

journal_title：Zeitschrift fur Rheumatologie

authors： Braun J,Mosch T,Fischer I,Kiltz U

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Since the introduction of biologic treatment in rheumatoid arthritis (RA), disease activity and treatment modalities have changed substantially. The current provision and developments in recent years are analyzed with annual data from the National Database of the Collaborative Arthritis Centers in Germany. ...

journal_title：Zeitschrift fur Rheumatologie

authors： Albrecht K,Huscher D,Eidner T,Kleinert S,Späthling-Mestekemper S,Bischoff S,Zink A

更新日期：2017-02-01 00:00:00