Abstract:
:This article explores the occurrence of U-shaped dose responses induced by neuroprotective agents in animal stroke and traumatic brain injury (TBI) screening/preclinical studies. The assessment was stimulated by suggestions that U-shaped dose responses may be common for neuroprotective agents in stroke and TBI models, and its lack of both recognition and understanding may be a factor contributing to the failure of many promising drugs to be protective in clinical trials. Over 30 agents with neuroprotective properties in animal stroke/TBI models were identified that act via U-shaped dose responses in a broad range of experimental protocols. These findings suggest that U-shaped dose responses in animal stroke/TBI models may be a general occurrence and have significant implications for drug discovery, drug development, and clinical practice.
journal_name
Crit Rev Toxicoljournal_title
Critical reviews in toxicologyauthors
Calabrese EJdoi
10.1080/10408440802014287subject
Has Abstractpub_date
2008-01-01 00:00:00pages
557-77issue
6eissn
1040-8444issn
1547-6898pii
794862548journal_volume
38pub_type
杂志文章,评审abstract::In the first half of the twentieth century epidemiologic evidence linked elevated incidences of pulmonary fibrosis and cancer with inhalation of chrysotile and crocidolite asbestos, a family of naturally occurring inorganic fibrous materials. As the serpentine and amphibole forms of asbestos were phased out, synthetic...
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journal_title:Critical reviews in toxicology
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abstract::Hydroquinone (HQ) is a high-volume commodity chemical used as a reducing agent, antioxidant, polymerization inhibitor, and chemical intermediate. It is also used in over-the-counter (OTC) drugs as an ingredient in skin lighteners and is a natural ingredient in many plant-derived products, including vegetables, fruits,...
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journal_title:Critical reviews in toxicology
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journal_title:Critical reviews in toxicology
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journal_title:Critical reviews in toxicology
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abstract::As long as no effective malaria vaccine is available, chemotherapy belongs to the most important weapons fighting malaria. One of the most promising new drug developments is the sesquiterpene artemisinin (ARS) and its derivatives, e.g., artemether, arteether, and sodium artesunate. Large clinical studies and meta-anal...
journal_title:Critical reviews in toxicology
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