Different functional boundaries for the major antigenic region of two cytochromes c.

abstract：:Opioid drugs produce their pharmacological effects by activating inhibitory guanine nucleotide-binding regulatory protein-linked mu, delta, and kappa opioid receptors. One major effector for these receptors is adenylyl cyclase, which is inhibited upon receptor activation. However, little is known about which of the te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim KS,Lee KW,Lee KW,Im JY,Yoo JY,Kim SW,Lee JK,Nestler EJ,Han PL

更新日期：2006-03-07 00:00:00

abstract：:Analysis of commercial catches reveals a serial depletion of some oceanic fish stocks over time, resulting in fisheries focusing on increasingly smaller species closer to the base of the food chain. This effect, described as fishing down the marine food web, is observed when the trophic level of the catch declines ove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dunlop ES,Goto D,Jackson DA

更新日期：2019-10-01 00:00:00

abstract：:Invading organisms may spread through local movements (giving rise to a diffusion-like process) and by long-distance jumps, which are often human-mediated. The local spread of invading organisms has been fit with varying success to models that couple local population growth with diffusive spread, but to date no quanti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suarez AV,Holway DA,Case TJ

更新日期：2001-01-30 00:00:00

abstract：:We have isolated from vaccinia virus cores an enzyme, 5'-phosphate-polyribonucleotide kinase, that in the presence of ATP and Mg2+ catalyzes the conversion of 5'-phosphate and 5'-diphosphate termini of RNA to the 5'-triphosphate species. With the exception of dATP, other nucleoside triphosphates were inactive as phosp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spencer E,Loring D,Hurwitz J,Monroy G

更新日期：1978-10-01 00:00:00

abstract：:We reported previously that Go-deficient mice develop severe neurological defects that include hyperalgesia, a generalized tremor, lack of coordination, and a turning syndrome somewhat reminiscent of unilateral lesions of the dopaminergic nigro-striatal pathway. By using frozen coronal sections of serially sectioned b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang M,Spicher K,Boulay G,Wang Y,Birnbaumer L

更新日期：2001-03-13 00:00:00

abstract：:Large quantities of mineral dust particles are frequently ejected into the atmosphere through the action of wind. The surface of dust particles acts as a sink for many gases, such as sulfur dioxide. It is well known that under most conditions, sulfur dioxide reacts on dust particle surfaces, leading to the production ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dupart Y,King SM,Nekat B,Nowak A,Wiedensohler A,Herrmann H,David G,Thomas B,Miffre A,Rairoux P,D'Anna B,George C

更新日期：2012-12-18 00:00:00

abstract：:High ambient ozone (O3) concentrations are a widespread and persistent problem globally. Although studies have documented the role of forests in removing O3 and one of its precursors, nitrogen dioxide (NO2), the cost effectiveness of using peri-urban reforestation for O3 abatement purposes has not been examined. We de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroeger T,Escobedo FJ,Hernandez JL,Varela S,Delphin S,Fisher JR,Waldron J

更新日期：2014-10-07 00:00:00

abstract：:The peptide chain release factor 2 (RF2) gene, prfB, was cloned from Salmonella typhimurium by DNA hybridization using the Escherichia coli prfB probe. The nucleotide and amino acid sequences of prfB are 87.0% and 95.6% homologous between E. coli and S. typhimurium, respectively, including an in-frame premature UGA st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawakami K,Nakamura Y

更新日期：1990-11-01 00:00:00

abstract：:We report the complete sequence of an extreme halophile, Halobacterium sp. NRC-1, harboring a dynamic 2,571,010-bp genome containing 91 insertion sequences representing 12 families and organized into a large chromosome and 2 related minichromosomes. The Halobacterium NRC-1 genome codes for 2,630 predicted proteins, 36...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ng WV,Kennedy SP,Mahairas GG,Berquist B,Pan M,Shukla HD,Lasky SR,Baliga NS,Thorsson V,Sbrogna J,Swartzell S,Weir D,Hall J,Dahl TA,Welti R,Goo YA,Leithauser B,Keller K,Cruz R,Danson MJ,Hough DW,Maddocks DG,Jabl

更新日期：2000-10-24 00:00:00

abstract：:The ovaries of the mosquito Aedes aegypti cultured in vitro secrete material that behaves like ecdysone in a radioimmunoassay. The material was identified as alpha-ecdysone by high-resolution liquid and gas-liquid chromatography. Secretion reached a maximum 16 hr after a blood meal as shown by bioassay and direct dete...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagedorn HH,O'Connor JD,Fuchs MS,Sage B,Schlaeger DA,Bohm MK

更新日期：1975-08-01 00:00:00

abstract：:The final step of ethylene biosynthesis in plants is catalyzed by the enzyme 1-aminocyclopropane-1-carboxylic acid (ACC) oxidase (ACCO). In addition to ACC, Fe(II), O2, CO2, and ascorbate are required for in vitro enzyme activity. Direct evidence for the role of the Fe(II) center in the recombinant avocado ACCO has no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rocklin AM,Tierney DL,Kofman V,Brunhuber NM,Hoffman BM,Christoffersen RE,Reich NO,Lipscomb JD,Que L Jr

更新日期：1999-07-06 00:00:00

abstract：:The complete amino acid sequence of Xenopus laevis nonmuscle myosin heavy chain B (MHC-B) has been deduced from overlapping cDNA clones isolated from an XTC cell library. RNA blots of various developmental stages, adult tissues, and XTC cells detect a single transcript of 7.5 kb which is expressed at similar levels th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhatia-Dey N,Adelstein RS,Dawid IB

更新日期：1993-04-01 00:00:00

abstract：:The function of many of the uncharacterized open reading frames discovered by genomic sequencing can be determined at the level of expressed gene products, the proteome. However, identifying the cognate gene from minute amounts of protein has been one of the major problems in molecular biology. Using yeast as an examp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shevchenko A,Jensen ON,Podtelejnikov AV,Sagliocco F,Wilm M,Vorm O,Mortensen P,Shevchenko A,Boucherie H,Mann M

更新日期：1996-12-10 00:00:00

abstract：:The human cerebral cortex contains many cell types that likely underwent independent functional changes during evolution. However, cell-type-specific regulatory landscapes in the cortex remain largely unexplored. Here we report epigenomic and transcriptomic analyses of the two main cortical neuronal subtypes, glutamat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kozlenkov A,Vermunt MW,Apontes P,Li J,Hao K,Sherwood CC,Hof PR,Ely JJ,Wegner M,Mukamel EA,Creyghton MP,Koonin EV,Dracheva S

更新日期：2020-11-10 00:00:00

abstract：:Alzheimer's disease (AD) is the most prevalent of a large group of related proteinopathies for which there is currently no cure. Here, we used Drosophila to explore a strategy to block Aβ42 neurotoxicity through engineering of the Heat shock protein 70 (Hsp70), a chaperone that has demonstrated neuroprotective activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandez-Funez P,Sanchez-Garcia J,de Mena L,Zhang Y,Levites Y,Khare S,Golde TE,Rincon-Limas DE

更新日期：2016-08-30 00:00:00

abstract：:Adrenocorticotropic hormone (ACTH) inhibited [3H]thymidine incorporation in normal adrenocortical cells of adult rats in culture, with a concomitant increase in corticosterone production and a characteristic retraction of cells. Both dibutyryl cyclic AMP and an analog of ACTH, which produces virtually no cyclic AMP, i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramachandran J,Suyama AT

更新日期：1975-01-01 00:00:00

abstract：:Nuclear factor of activated T cells (NFAT) proteins are Ca(2+)-regulated transcription factors that control gene expression in many cell types. NFAT proteins are heavily phosphorylated and reside in the cytoplasm of resting cells; when cells are stimulated by a rise in intracellular Ca(2+), NFAT proteins are dephospho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma S,Findlay GM,Bandukwala HS,Oberdoerffer S,Baust B,Li Z,Schmidt V,Hogan PG,Sacks DB,Rao A

更新日期：2011-07-12 00:00:00

abstract：:DNA methylation is an epigenetic mark that silences transposable elements (TEs) and repeats. Whereas the establishment and maintenance of DNA methylation are relatively well understood, little is known about their dynamics and biological relevance in plant and animal innate immunity. Here, we show that some TEs are de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu A,Lepère G,Jay F,Wang J,Bapaume L,Wang Y,Abraham AL,Penterman J,Fischer RL,Voinnet O,Navarro L

更新日期：2013-02-05 00:00:00

abstract：:Adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] activity of purified secretory vesicle membranes from the adrenal medulla is inhibited by I-isoproterenol and I-epinephrine, as well as by nerve growth factor (NGF). The effect of these agents was found to be dose-dependent and, in the case of the cat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikodijevic O,Nikodijevic B,Zinder O,Yu MY,Guroff G,Pollard HB

更新日期：1976-03-01 00:00:00

abstract：:Iron is an essential nutrient for the survival of most organisms and has played a central role in the virulence of many infectious disease pathogens. Mycobacterial IdeR is an iron-dependent repressor that shows 80% identity in the functional domains with its corynebacterial homologue, DtxR (diphtheria toxin repressor)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manabe YC,Saviola BJ,Sun L,Murphy JR,Bishai WR

更新日期：1999-10-26 00:00:00

abstract：:Cleavage of precursor proteins occurs during assembly of numerous viruses. Seven bacteriophage T4 head-related proteins areknown to be cleaved during morphogenesis. Sequences surrounding the cleavage sites in T4 head precursors P23 and IPIII are reported here. We previously determined the sequences of precursor and pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Isobe T,Black LW,Tsugita A

更新日期：1976-11-01 00:00:00

abstract：:All life on Earth is built of organic molecules, so the primordial sources of reduced carbon remain a major open question in studies of the origin of life. A variant of the alkaline-hydrothermal-vent theory for life's emergence suggests that organics could have been produced by the reduction of CO2 via H2 oxidation, f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hudson R,de Graaf R,Strandoo Rodin M,Ohno A,Lane N,McGlynn SE,Yamada YMA,Nakamura R,Barge LM,Braun D,Sojo V

更新日期：2020-09-15 00:00:00

abstract：:Sea urchins are a major component of recent marine communities where they exert a key role as grazers and benthic predators. However, their impact on past marine organisms, such as crinoids, is hard to infer in the fossil record. Analysis of bite mark frequencies on crinoid columnals and comprehensive genus-level dive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorzelak P,Salamon MA,Baumiller TK

更新日期：2012-05-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF), a cognate ligand for the tyrosine kinase receptor B (TrkB) receptor, mediates neuronal survival, differentiation, synaptic plasticity, and neurogenesis. However, BDNF has a poor pharmacokinetic profile that limits its therapeutic potential. Here we report the identification of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang SW,Liu X,Yepes M,Shepherd KR,Miller GW,Liu Y,Wilson WD,Xiao G,Blanchi B,Sun YE,Ye K

更新日期：2010-02-09 00:00:00

abstract：:Most natural populations are affected by seasonal changes in temperature, rainfall, or resource availability. Seasonally fluctuating selection could potentially make a large contribution to maintaining genetic polymorphism in populations. However, previous theory suggests that the conditions for multilocus polymorphis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wittmann MJ,Bergland AO,Feldman MW,Schmidt PS,Petrov DA

更新日期：2017-11-14 00:00:00

abstract：:A weakly nonlinear oscillator of natural frequency omega(0) and damping ratio delta is driven by an amplitude-modulated force of dimensionless amplitude epsilon, carrier frequency omega, and modulation frequency omega(1). Each of (omega - omega(0))/omega(0), omega(1)/omega(0), and delta is O(epsilon(2/3)) as epsilon -...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles J

更新日期：1984-06-01 00:00:00

abstract：:Social status motivates much of human behavior. However, status may have been a relatively weak target of selection for much of human evolution if ancestral foragers tended to be more egalitarian. We test the "egalitarianism hypothesis" that status has a significantly smaller effect on reproductive success (RS) in for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： von Rueden CR,Jaeggi AV

更新日期：2016-09-27 00:00:00

abstract：:The problem of Congressional apportionment is explained together with a brief history of the methods used or considered for its solution. Reasons are given for rejecting the presently used method of equal proportions and for accepting a new method, the quota method, which is the unique method satisfying three essentia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balinski ML,Young HP

更新日期：1974-11-01 00:00:00

abstract：:Very-long-baseline interferometry images of the nuclear region of the radio galaxy Cygnus A reveal a pronounced "core" and a knotty jet and counterjet. The knots are moving away from the core at apparent speeds which are subluminal for h = 1 [h = H0/100 km.s-1.Mpc-1;1 parsec (pc) = 3.09 x 10(16)m] and about c for h = ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartel N,Sorathia B,Bietenholz MF,Carilli CL,Diamond P

更新日期：1995-12-05 00:00:00

abstract：:To define the gene content of the HLA class I region, cDNA selection was applied to three overlapping yeast artificial chromosomes (YACs) that spanned 1 megabase (Mb) of this region of the human major histocompatibility complex. These YACs extended from the region centromeric to HLA-E to the region telomeric to HLA-F....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei H,Fan WF,Xu H,Parimoo S,Shukla H,Chaplin DD,Weissman SM

更新日期：1993-12-15 00:00:00