Abstract：
:A variety of immunological abnormalities have been reported in some patients with amyotrophic lateral sclerosis (ALS). It has been postulated that a disturbance of immunoregulation may play a role in the degeneration of motor neurons in ALS. We describe a 62-year-old man with a 9-month history of slowly progressive muscular weakness and atrophy of the upper and lower extremities and dysarthria. Neurological examinations revealed weakness and atrophy with fasciculation in the skeletal muscles including the face and tongue. In the limbs, distal muscles were affected predominantly. Electromyography showed chronic neurogenic changes with denervation potentials. Serum antibody testing demonstrated an increased titer of anti-N-acetylgalactosaminyl GD1a (GalNAc-GD1a) antibodies (IgGx160; normal, less than x40). The patient was treated with intravenous immunoglobulin (IVIg) therapy which was repeated two times at an interval of 2 months. However, the response to IVIg was negligible. To the authors' knowledge, this is the first report on ALS, in which the patient had anti-GalNAc-GD1a IgG antibody.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Yamazaki T,Suzuki M,Irie T,Watanabe T,Mikami H,Ono Sdoi
10.1016/j.clineuro.2008.03.010subject
Has Abstractpub_date
2008-07-01 00:00:00pages
722-4issue
7eissn
0303-8467issn
1872-6968pii
S0303-8467(08)00113-3journal_volume
110pub_type
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journal_title：Clinical neurology and neurosurgery
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,meta分析,评审
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更新日期：2002-05-01 00:00:00
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doi：10.1016/j.clineuro.2016.04.014
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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pub_type： 杂志文章
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章,评审
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更新日期：2007-09-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
pub_type： 杂志文章
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更新日期：2008-06-01 00:00:00
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journal_title：Clinical neurology and neurosurgery
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更新日期：2009-06-01 00:00:00
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更新日期：2015-08-01 00:00:00
