Abstract:
:The natural course of clinical manifestations and electrophysiological changes were studied in six patients with carbon disulfide (CS(2)) induced polyneuropathy. All of the six patients worked in the cutting-machine department of a viscose rayon plant. The environmental monitoring was also conducted in the initial stage and followed up 3 years later. In the 3-year follow-up period, the neurological symptoms and signs persisted. The highest concentration of CS(2) in the cutting machine where these patients worked was about 100-200 ppm. Three years later, the highest concentration was decreased to between 10 and 20 ppm in the cutting machine of the new production line after the engineering control had been improved. Nerve conduction velocity (NCV) studies revealed persistent abnormality in motor and sensory NCVs. Although, a tendency to improvement was noted, it did not reach a statistical significance except for conduction velocity of sural nerve in sensory NCV. Sural nerve biopsy from one patient, 2 years after diagnosis showed degeneration of both axon and myelin and a predominant loss of large myelinated fibers. A remyelination process was also noted. We concluded that CS(2) intoxication may induce a persistent damage to the peripheral nerves even after CS(2) exposure had ceased for 3 years.
journal_name
Clin Neurol Neurosurgjournal_title
Clinical neurology and neurosurgeryauthors
Huang CC,Chu CC,Wu TN,Shih TS,Chu NSdoi
10.1016/s0303-8467(01)00187-1keywords:
subject
Has Abstractpub_date
2002-05-01 00:00:00pages
115-20issue
2eissn
0303-8467issn
1872-6968pii
S0303846701001871journal_volume
104pub_type
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
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journal_title:Clinical neurology and neurosurgery
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2009.12.005
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章,评审
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/S0303-8467(15)30009-3
更新日期:2015-02-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2018.02.031
更新日期:2018-04-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2005.08.007
更新日期:2006-09-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2009.09.003
更新日期:2010-01-01 00:00:00
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doi:10.1016/j.clineuro.2016.03.019
更新日期:2016-06-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/0303-8467(95)00087-9
更新日期:1996-02-01 00:00:00
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doi:10.1016/0303-8467(92)90049-9
更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2014-07-01 00:00:00
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doi:10.1016/j.clineuro.2017.04.001
更新日期:2017-06-01 00:00:00
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更新日期:1984-01-01 00:00:00
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更新日期:2019-09-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
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doi:10.1016/j.clineuro.2009.07.004
更新日期:2009-10-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2012.01.007
更新日期:2012-07-01 00:00:00
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journal_title:Clinical neurology and neurosurgery
pub_type: 杂志文章
doi:10.1016/j.clineuro.2018.04.017
更新日期:2018-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.clineuro.2016.06.009
更新日期:2016-10-01 00:00:00