Cell-mediated immunity to varicella-zoster virus demonstrated by viral inactivation with human leukocytes.

Abstract:

:Cell-mediated immunity to varicella-zoster (V-Z) virus in persons immune to varicella has been demonstrated, using a tissue culture technique. Cell-mediated immunity was reflected by the ability of peripheral leukocytes (lymphocytes and monocytes) from human donors to inactivate V-Z virus. Leukocytes were stimulated by the addition of noninfectious V-Z antigen to cultures newly infected with V-Z virus. Several days leter, the V-Z virus in these cultures was titered. When leukocytes from donors immune to caricella were used, a significant decrease in V-Z titer, compared with controls, was noted. When leukocytes from donors susceptible to varicella were tested, no decrease in V-Z virus titer was found. A mixed population of lymphocytes and monocytes from immune donors was required to demonstrate inactivation of V-Z virus. The development of specific cell-mediated immunity to V-Z virus may play a role in termination of varicella and in prevention of second attacks of this disease.

journal_name

Infect Immun

journal_title

Infection and immunity

authors

Gershon AA,Steinberg S,Smith M

doi

10.1128/IAI.13.6.1549-1553.1976

subject

Has Abstract

pub_date

1976-06-01 00:00:00

pages

1549-53

issue

6

eissn

0019-9567

issn

1098-5522

journal_volume

13

pub_type

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