Homocysteine, vitamin B12 and folate status in pediatric acute lymphoblastic leukemia.

Abstract:

OBJECTIVE:The cause of majority of acute leukemias is unknown, but likely to involve interaction of environment, hematopoitic development and weak susceptibility loci within an individual's genetic constitution. The present study evaluates the association between plasma levels of homocysteine, folate and vitamin B12 and acute lymphoblastic leukemia. METHODS:Plasma levels of homocysteine, folate and vitamin B12 were compared between cases of acute lymphoblastic leukemia and age and sex matched normal controls. Homocysteine levels were measured by solid immunoassay, while folate and vitamin B12 levels were determined by radioassay. RESULTS:Folate levels were significantly among cases as compared to control group (8.56 +/- 4.35) vs (14.04 +/- 2.62) ng/ml, P< 0.001). Although individually vitamin B12 and homocysteine were not significant different between cases and controls, the combined effect of all three parameters was significantly different (P< 0.001), with 83.3% of correct classification of cases and controls was obtained by discriminate function analysis. CONCLUSION:The data provide evidence for the role of folate, vitamin B12 and homocysteine levels in acute lymphoblastic leukemia, suggesting that gene-environment interaction may be an important factor in the development of acute lymphoblastic leukemia.

journal_name

Indian J Pediatr

authors

Sadananda Adiga MN,Chandy S,Ramaswamy G,Appaji L,Krishnamoorthy L

doi

10.1007/s12098-008-0051-4

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

235-8

issue

3

eissn

0019-5456

issn

0973-7693

journal_volume

75

pub_type

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