Abstract：
BACKGROUND:Desmoplastic melanoma (DM) is a rare subtype of cutaneous malignant melanoma reported to have a high local recurrence rate with surgical excision alone. The incidence of regional and distant metastasis is considered to be lower than traditional cutaneous melanoma, warranting more aggressive treatment of local disease. We conducted a retrospective analysis of patients with DM treated through the Princess Alexandra Hospital Melanoma Clinic to address the role of radiotherapy in the local control of this tumour. METHODS:A review of a clinical database identified 24 patients between January 1997 and March 2006 with histopathologically confirmed DM who had received surgical excision as initial treatment followed by postoperative radiotherapy. All histopathology reports and radiotherapy treatment plans were reviewed. The primary outcome measure was 3-year in-field relapse-free survival. RESULTS:There were 24 patients with 22 having a DM in the head and neck region. The median tumour thickness was 5.2 mm. The histopathological margin was less than 10 mm in 17 (71%) of patients. The 3-year in-field relapse-free survival was 91% (95% confidence interval 68.1-97.6%), the 3-year relapse-free survival was 86% (95% confidence interval 63.2-95.4%) with a 3-year overall survival of 83% (95% confidence interval 54.9-94.3%). CONCLUSION:In a selected series of patients with DM with a high risk of local recurrence, adjuvant radiotherapy may have been effective in reducing the rate of local recurrence after surgical resection. A randomized trial is currently being developed to confirm this possible benefit.
journal_name
ANZ J Surgjournal_title
ANZ journal of surgeryauthors
Foote MC,Burmeister B,Burmeister E,Bayley G,Smithers BMdoi
10.1111/j.1445-2197.2008.04436.xsubject
Has Abstractpub_date
2008-04-01 00:00:00pages
273-6issue
4eissn
1445-1433issn
1445-2197pii
ANS4436journal_volume
78pub_type
杂志文章abstract：BACKGROUND:Late laparoscopic cholecystectomy (LC) after endoscopic retrograde cholangiopancreatography (ERCP) and sphincterotomy (ES) for common bile duct (CBD) stone clearance, two-stage LC (TSLC), is associated with difficult surgical dissection and an increased rate of conversion to open procedure. The purpose of th...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.12967
更新日期：2016-01-01 00:00:00
abstract：INTRODUCTION:Ludwig's angina (LA) is an uncommon and potentially life-threatening condition of the upper aero-digestive tract that often requires the coordinated efforts of the surgical, anesthetic and intensive care teams to optimize management. The purpose of the present study was to investigate the documented clinic...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
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journal_title：ANZ journal of surgery
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doi：10.1111/ans.14395
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Anaplastic thyroid carcinoma (ATC) accounts for <5% of all thyroid malignancies and is one of the most aggressive malignancies known. Survival is limited to months and death is often caused by uncontrolled neck disease. There is evidence that multimodality treatment, incorporating surgery (Sx), external beam...
journal_title：ANZ journal of surgery
pub_type： 杂志文章,评审
doi：10.1111/j.1445-2197.2004.03062.x
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journal_title：ANZ journal of surgery
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doi：10.1111/j.1445-2197.2007.04028.x
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pub_type： 杂志文章
doi：10.1111/j.1445-2197.2007.04260.x
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abstract：BACKGROUND:Depletion of liver glycogen stores and subsequent hypoglycaemia is one of the unresolved features in endotoxaemia. The aim of this study was to elucidate the effect of L-arginine treatment on the glucose requirement and impending liver damage during the hypoglycaemic period of endotoxaemia. METHODS:Sixty-th...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
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更新日期：2006-06-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章,多中心研究
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journal_title：ANZ journal of surgery
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journal_title：ANZ journal of surgery
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15282
更新日期：2019-07-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 传,历史文章,杂志文章
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更新日期：2019-12-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
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更新日期：2019-09-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 历史文章,杂志文章
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更新日期：2005-05-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15506
更新日期：2020-01-01 00:00:00
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journal_title：ANZ journal of surgery
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pub_type： 杂志文章
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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journal_title：ANZ journal of surgery
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更新日期：2020-11-05 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章,评审
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更新日期：2014-04-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
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更新日期：2005-11-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2005.03526.x
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-1433.2004.03226.x
更新日期：2004-11-01 00:00:00
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journal_title：ANZ journal of surgery
pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
abstract：INTRODUCTION:There are very little clinical and pathological data on colorectal cancer among Indigenous people in Australia. METHODS:A retrospective study on Indigenous patients treated for colorectal cancer at the Townsville and Cairns Base Hospitals from 1999 to 2004 was carried out in order to better characterise t...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2005.03592.x
更新日期：2005-11-01 00:00:00
