Anaplastic thyroid carcinoma: dismal outcome despite current treatment approach.

Abstract:

BACKGROUND:Anaplastic thyroid carcinoma (ATC) accounts for <5% of all thyroid malignancies and is one of the most aggressive malignancies known. Survival is limited to months and death is often caused by uncontrolled neck disease. There is evidence that multimodality treatment, incorporating surgery (Sx), external beam radiotherapy (RT) and chemotherapy (CT), might enhance local control and improve survival. METHODS:Between 1979 and 2002, 18 patients with ATC were referred to the multidisciplinary Head and Neck Cancer Service, Westmead Hospital, Sydney, Australia. The aim of the present study is to report on the treatment and outcome of these patients. Survival was calculated from the time of diagnosis until death using the Kaplan-Meier method. RESULTS:Median age at diagnosis was 72 years (29-92 years) in 12 women and six men. Five patients had distant metastases at diagnosis. Seven patients were treated with various combinations of Sx, RT and/or CT. Ten patients received a single modality, including three undergoing a total thyroidectomy. Many patients died from local disease progression. Only one patient received triple modality treatment (Sx/RT/CT), surviving 26 months, and maintaining local control until death. Sixteen patients died from disease with a median survival of 6.2 months (0.3-56.8 months). CONCLUSION:Most patients with ATC are incurable; however, a multimodality approach incorporating Sx and RT +/- CT, in selected individuals, might improve local control and extend survival.

journal_name

ANZ J Surg

journal_title

ANZ journal of surgery

authors

Veness MJ,Porter GS,Morgan GJ

doi

10.1111/j.1445-2197.2004.03062.x

keywords:

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

559-62

issue

7

eissn

1445-1433

issn

1445-2197

pii

ANS3062

journal_volume

74

pub_type

杂志文章,评审
  • Caseload distribution of general surgeons in regional Australia: is there a role for a rural surgery sub-specialization?

    abstract:BACKGROUND:Rural and regional Australia presents a unique challenge in the delivery of surgical services by virtue of its geographical vastness and low population density. While up to 33% of Australians live in rural or regional areas, only 14.8% of surgeons work in a rural or regional area. Data regarding the caseload...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.14680

    authors: Bappayya S,Chen F,Alderuccio M,Schwalb H

    更新日期:2019-06-01 00:00:00

  • Bilateral thoracoscopy, mediastinoscopy and laparoscopy, in addition to CT, MRI and PET imaging, are essential to correctly stage and treat patients with mesothelioma prior to trimodality therapy.

    abstract:BACKGROUND:Trimodality therapy (TMT; extrapleural pneumonectomy (EPP), chemotherapy and radiation therapy) offers the potential of optimal survival in selected patients with Brigham stage I-II epitheliod mesothelioma based on CT, MRI and PET scanning. We hypothesized that these scanning modalities were inadequate to ac...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2009.05060.x

    authors: Alvarez JM,Hasani A,Segal A,Sterret G,Millward M,Nowak A,Musk W,Bydder S

    更新日期:2009-10-01 00:00:00

  • Adenoid cystic carcinoma of the trachea: a long-term problem.

    abstract::Adenoid cystic carcinoma of the trachea, although rare, is the second most common primary tumour of the trachea. It is a slow-growing tumour found in younger patients than the more common squamous cell carcinoma and is relatively resistant to treatment, but metastasizes late in the course of disease and even in unrese...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2006.03848.x

    authors: Clough A,Clarke P

    更新日期:2006-08-01 00:00:00

  • Desmoplastic melanoma: the role of radiotherapy in improving local control.

    abstract:BACKGROUND:Desmoplastic melanoma (DM) is a rare subtype of cutaneous malignant melanoma reported to have a high local recurrence rate with surgical excision alone. The incidence of regional and distant metastasis is considered to be lower than traditional cutaneous melanoma, warranting more aggressive treatment of loca...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2008.04436.x

    authors: Foote MC,Burmeister B,Burmeister E,Bayley G,Smithers BM

    更新日期:2008-04-01 00:00:00

  • Laparoscopic gastric resection for benign and malignant conditions: lessons learned from 35 consecutive cases.

    abstract:INTRODUCTION:Despite significant advances in laparoscopy, gastric surgery is still generally carried out by conventional open techniques. The aim of the study was to report the short- and medium-term outcomes of gastric surgery when carried out laparoscopically for a variety of benign and malignant conditions. METHODS...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2007.04224.x

    authors: Liew V,Taylor C,Ghusn M,Jamnagerwalla M,Layani L

    更新日期:2007-09-01 00:00:00

  • Treatment of scaphoid fractures using a memory alloy nail-feet-fixation device.

    abstract:BACKGROUND:Scaphoid fracture is a common carpal fracture, and its treatment often requires fixation devices. This study aimed to investigate the efficacy and safety of a memory alloy nail-feet-fixation (MANFF) device in treating scaphoid fractures. METHODS:Sixty-six patients with closed scaphoid fractures were treated...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.13641

    authors: Li C,Xu X,Su Y,Zhou T,Fan X,Xu Y

    更新日期:2016-07-01 00:00:00

  • Neoadjuvant chemoradiotherapy for rectal cancer: how important is tumour regression?

    abstract:BACKGROUND:Pathological complete response following neoadjuvant chemoradiotherapy (CRT) for locally advanced rectal cancer is associated with reduced local recurrence and improved long-term outcome. However, the prognostic value of a partial response, or of tumour regression in patients with metastatic disease, is less...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.13394

    authors: McCoy MJ,Hemmings C,Hillery S,Penter C,Bulsara MK,Zeps N,Platell CF

    更新日期:2017-12-01 00:00:00

  • Why do surgeons receive more complaints than their physician peers?

    abstract:BACKGROUND:Compared with other doctors, surgeons are at an increased risk of medicolegal events, including patient complaints and negligence claims. This retrospective study aimed to describe the frequency and nature of complaints involving surgeons compared with physicians. METHODS:We assembled a national data set of...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.14225

    authors: Tibble HM,Broughton NS,Studdert DM,Spittal MJ,Hill N,Morris JM,Bismark MM

    更新日期:2018-04-01 00:00:00

  • Long-term comparison of external valvular stenting and stripping of varicose veins.

    abstract:BACKGROUND:The recurrence rate following stripping of the long saphenous vein is unacceptable. Repair of the terminal valve of the long saphenous vein is a physiological alternative. The aim of the present study was to prospectively compare the long-term recurrence rates in patients having had reparative and ablative p...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1046/j.1445-2197.2003.02714.x

    authors: Lane RJ,Graiche JA,Coroneos JC,Cuzzilla ML

    更新日期:2003-08-01 00:00:00

  • Hepatic artery thrombosis and intraoperative hepatic artery flow rates in adult orthotopic liver transplantation.

    abstract:INTRODUCTION:Thrombosis of the hepatic artery following orthotopic liver transplantation (OLT) can be a devastating com-plication impacting on recipient outcome. The utility of routine intraoperative flow measurements of the hepatic artery in predicting subsequent hepatic artery thrombosis (HAT) is presented in this st...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1046/j.1445-2197.2002.02552.x

    authors: Lin M,Crawford M,Fisher J,Hitos K,Verran D

    更新日期:2002-11-01 00:00:00

  • Internal pancreatic fistulas with pancreatic ascites and pancreatic pleural effusions: recognition and management.

    abstract:BACKGROUND:Internal pancreatic fistulas are well recognized complications of chronic pancreatitis. METHODS:Six patients with internal pancreatic fistulas were treated over a period of 5 years from 1995 to 1999. Four patients presented with ascites, one patient presented with ascites and bilateral pleural effusion and ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1046/j.1440-1622.2001.02077.x

    authors: Kaman L,Behera A,Singh R,Katariya RN

    更新日期:2001-04-01 00:00:00

  • Impact of COVID-19-related social restrictions on orthopaedic trauma in a level 1 trauma centre in Sydney: the first wave.

    abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) pandemic has affected communities worldwide. This study examines the impact that public health measures to control viral spread have had on orthopaedic trauma presenting to an Australian level 1 trauma centre. We hypothesized that the volume of orthopaedic trauma in th...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.16375

    authors: Probert AC,Sivakumar BS,An V,Nicholls SL,Shatrov JG,Symes MJ,Ellis AM

    更新日期:2020-10-13 00:00:00

  • Nausea, vomiting and return of bowel function after colorectal surgery.

    abstract:BACKGROUND:Although patterns of return of bowel function (ROBF) following colorectal surgery with enhanced recovery after surgery (ERAS) programmes have been well delineated, regular morphine use is uncommon. This study describes the patterns of post-operative nausea and vomiting (PONV) and ROBF in this context. METHO...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.13290

    authors: Barclay KL,Zhu YY,Tacey MA

    更新日期:2015-11-01 00:00:00

  • Paediatric appendicitis: increased disease severity and complication rates in rural children.

    abstract:BACKGROUND:Appendicitis is the most common surgical emergency affecting children. Rurality has been shown to be a predictor of worse surgical outcomes in patients with acute appendicitis compared to urban residents. There are no previously published studies investigating this in Australasia. METHODS:A 10-year retrospe...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.15328

    authors: Elliott BM,Witcomb Cahill H,Harmston C

    更新日期:2019-09-01 00:00:00

  • How to do it: value-driven sharp recanalization of central vein occlusion.

    abstract::Patients on haemodialysis are susceptible for central vein occlusions, which can result in debilitating clinical consequences. These may be resistant to conventional revascularization with guidewire and catheter technique. Value-driven sharp recanalization of central vein occlusion is depicted as a safe and affordable...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.15599

    authors: Yoong GSW,Koh FHX,Wee BBK,Anil G,Ho P

    更新日期:2020-03-01 00:00:00

  • Systematic review of the impact of sacral neuromodulation on clinical symptoms and gastrointestinal physiology.

    abstract:BACKGROUND:Sacral neuromodulation (SNM) has emerged as a treatment option for faecal incontinence (FI). However, its objective effect on symptoms and anorectal function is inconsistently described. This study aimed to systematically review the impact of SNM on clinical symptoms and gastrointestinal physiology in patien...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1111/ans.13257

    authors: Mirbagheri N,Sivakumaran Y,Nassar N,Gladman MA

    更新日期:2016-04-01 00:00:00

  • Gastrin is not required for liver regeneration.

    abstract:BACKGROUND:Although several growth factors are known to be essential for liver regeneration, the role of gastrin remains controversial. METHODS:Liver regeneration was examined in wild-type (WT) and gastrin-deficient (gastrin KO) mice at days 2 and 10 after partial (40%) hepatectomy by measurement of liver weight. Hepa...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2007.04360.x

    authors: Dizdarevic A,Harun N,Malcontenti-Wilson C,Shulkes A,Christophi C,Baldwin GS

    更新日期:2008-01-01 00:00:00

  • Endovascular grafting of the thoracic aorta, an evolving therapy: ten-year experience in a single centre.

    abstract:BACKGROUND:Surgical therapy for the thoracic aorta carries a high morbidity and mortality. Endovascular therapy for aneurysms and its adaptation to the thoracic aorta over the past 10 years is an exciting advance. This is a retrospective review of endovascular grafting of the thoracic aorta during the past decade at Ro...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2007.04293.x

    authors: Sandroussi C,Waltham M,Hughes CF,May J,Harris JP,Stephen MS,White GH

    更新日期:2007-11-01 00:00:00

  • Ten-year review of gastrointestinal stromal tumours at a tertiary referral hospital in New Zealand.

    abstract:BACKGROUND:Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract and make up 1-2% of all gastrointestinal malignancies. Traditionally, the treatment of choice for primary disease is surgical resection; however, no single surgeon or institution gets extensive expo...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.12429

    authors: Siu J,Lim M,Fischer J,Dobbs B,Wakeman C,Ing A,Frizelle F

    更新日期:2016-03-01 00:00:00

  • Surgical wisdom and Genghis Khan's Pax Mongolica.

    abstract:BACKGROUND:The unrivalled conquests of Genghis Khan (CE c.1162-1227) led to the establishment of the Greater Mongolian Empire. By 1279, the Mongol dynasty controlled a vast Empire which, for the first time in history, unified Europe and China via the famous Silk Road. The ensuing century of peace and stability is refer...

    journal_title:ANZ journal of surgery

    pub_type: 历史文章,杂志文章

    doi:10.1111/ans.13813

    authors: Köstenbauer J

    更新日期:2017-03-01 00:00:00

  • Tracheal repair in children: reduction of mortality with advent of slide tracheoplasty.

    abstract:BACKGROUND:Severe tracheal stenosis is a rare life-threatening condition that often requires early surgical intervention. The management of this anomaly has been associated with significant mortality and morbidity. We describe our experience with repair of this condition. METHODS:From 1986 to 2011, 20 patients underwe...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.12132

    authors: Yong MS,d'Udekem Y,Robertson CF,Butt W,Brizard CP,Konstantinov IE

    更新日期:2014-10-01 00:00:00

  • Necrotizing myositis: highlighting the hidden depths - case series and review of the literature.

    abstract:BACKGROUND:Necrotizing myositis (NM) is a life-threatening emergency. It causes focal muscle necrosis without abscess formation or extensive involvement of the overlying fascia and soft tissue. It is a clinical diagnosis requiring a high index of clinical suspicion. Usual presentation can readily be mistaken to represe...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1111/ans.15429

    authors: Khanna A,Gurusinghe D,Taylor D

    更新日期:2020-01-01 00:00:00

  • Paediatric constipation for adult surgeons--article 1: targeting the cause.

    abstract::Constipation is very common in all age groups and can be resistant to standard therapies, producing chronic morbidity. Childhood onset constipation frequently produces symptoms that persist into adulthood. Recent advances have been made in the diagnosis and treatment of childhood constipation that could have applicati...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1111/j.1445-1433.2004.03149.x

    authors: Sutcliffe JR,King SK,Southwell BR,Hutson JM

    更新日期:2004-09-01 00:00:00

  • Acute forearm compartment syndrome following haemodialysis access fistula puncture in uraemia.

    abstract:BACKGROUND:Acute compartment syndrome is a well-described surgical emergency that requires immediate diagnosis and operative intervention. Vascular access-associated compartment syndrome is rarely reported in haemodialysis patients. The purpose of this article is to document evidence that catheter-related puncture, whi...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.12701

    authors: Lin CT,Dai NT,Chen SG,Chang SC

    更新日期:2016-10-01 00:00:00

  • Two-year serum metal ion levels in minimally invasive total conservative hip resurfacing: preliminary results of a prospective study.

    abstract:BACKGROUND:Metal-on-metal (MoM) hip resurfacings have been associated with the potential development of metallic debris and its associated pathology. Serum cobalt and chromium levels are a reliable surrogate marker of wear rates in MoM bearings. The aim of the study was to examine the trend in serum metal ion levels in...

    journal_title:ANZ journal of surgery

    pub_type: 临床试验,杂志文章

    doi:10.1111/ans.12868

    authors: Tai SM,Millard N,Munir S,Jenabzadeh AR,Walter LR,Walter WL

    更新日期:2015-03-01 00:00:00

  • Workplace-based assessment: assessing technical skill throughout the continuum of surgical training.

    abstract::The Royal Colleges of Surgeons and Surgical Specialty Associations in the UK have introduced competence-based syllabi and curricula for surgical training. The syllabi of the Intercollegiate Surgical Curriculum Programme (ISCP) and Orthopaedic Curriculum and Assessment Programme (OCAP) define the core competencies, tha...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2008.04832.x

    authors: Beard J,Rowley D,Bussey M,Pitts D

    更新日期:2009-03-01 00:00:00

  • Interventional management of necrotizing pancreatitis: an Australian experience.

    abstract:BACKGROUND:The interventional management of necrotizing pancreatitis has evolved from early open surgery to delayed endoscopic or percutaneous intervention. However, few studies have directly compared the three treatment modalities. We aim to compare the outcomes of patients who had endoscopic, percutaneous or surgical...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.13381

    authors: Woo S,Walklin R,Wewelwala C,Berry R,Devonshire D,Croagh D

    更新日期:2017-09-01 00:00:00

  • Laryngoscopic techniques to assess vocal cord mobility following thyroid surgery.

    abstract:BACKGROUND:Assessment of vocal cord mobility using Macintosh laryngoscope is frequently performed after extubation following thyroid surgery to rule out laryngeal nerve palsy. This study compared patient comfort and assessment accuracy of post-operative vocal fold mobility with Macintosh laryngoscope and fibreoptic end...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/j.1445-2197.2010.05441.x

    authors: Kundra P,Kumar V,Srinivasan K,Gopalakrishnan S,Krishnappa S

    更新日期:2010-11-01 00:00:00

  • How could management of rectoceles be optimized?

    abstract::A posterior vaginal wall prolapse, also known as a rectocele, is a common condition and is an outpouching of the posterior vaginal wall and anterior rectal wall into the lumen of the vagina.1-5 Although more common in parous women, rectoceles of over 1 cm in size have been demonstrated in over 40% of nulliparous women...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章,评审

    doi:10.1046/j.1445-2197.2002.t01-1-02577.x

    authors: Goh JT,Tjandra JJ,Carey MP

    更新日期:2002-12-01 00:00:00

  • Quad bike injuries at an Australian regional hospital: a trauma registry review.

    abstract:BACKGROUND:Quad bikes are a prominent cause of morbidity and mortality in Australia in both agriculture and recreation. This study describes the clinical and epidemiological characteristics of quad bike injuries at the Royal Darwin Hospital (RDH). METHODS:A retrospective review of the RDH Trauma Registry for all quad ...

    journal_title:ANZ journal of surgery

    pub_type: 杂志文章

    doi:10.1111/ans.15631

    authors: Liddle SE,McDermott KM,Ward LM,Lim HH,Read DJ

    更新日期:2020-04-01 00:00:00