Abstract:
BACKGROUND:Interleukin-12 (IL-12) has been shown to enhance the cytotoxic activity of NK cells and CTL. IL-12 also acts as a growth factor for activated NK, T and NKT cells. The soluble HLA class I (sHLA-I) has been reported to bind a killer-cell inhibitory receptor, which is expressed on the NK cell, and its signals inhibit NK cell-mediated cytotoxicity. Effects of fresh frozen plasma (FFP) on post-operative immune status have not yet been completely examined. METHODS:Thirty consecutive patients taking a hepatectomy were enrolled. The levels of IL-12 and sHLA-I were examined by enzyme-linked immunosorbent assay. RESULTS:The rate of complication after hepatectomy in the FFP-administered patients was higher than that in patients without FFP administration (P = 0.0358). Decreased IL-12 levels after surgery in patients without FFP administration recovered to the preoperative state earlier than those in patients with FFP administration (P < 0.05). The levels of sHLA-I in the FFP-administered patients were higher than those in the patients without FFP administration (P < 0.05). CONCLUSIONS:Administration of FFP, which contains sHLA-I, affected the levels of sHLA-I after hepatectomy. Both high levels of sHLA-I and low levels of IL-12 could attenuate NK activities after hepatectomy, especially when FFP would be administered.
journal_name
ANZ J Surgjournal_title
ANZ journal of surgeryauthors
Shimura T,Morinaga N,Suzuki H,Araki K,Kobayashi T,Ishizaki M,Kuwano Hdoi
10.1111/j.1445-2197.2009.04947.xsubject
Has Abstractpub_date
2009-06-01 00:00:00pages
462-6issue
6eissn
1445-1433issn
1445-2197pii
ANS4947journal_volume
79pub_type
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