Abstract：
BACKGROUND:The isolated limb infusion (ILI) technique is a simpler and less invasive alternative to isolated limb perfusion, which allows regional administration of high-dose chemotherapy to patients with advanced melanoma and other malignancies restricted to a limb. METHODS:Patients from two institutions, treated by ILI between 1998 and 2009 for extensive disease restricted to a limb, were included. The cohort included 31 patients with melanoma who presented with in-transit metastases or an extensive primary lesion, one patient with squamous cell carcinoma and another with epithelioid sarcoma not suitable for local surgical treatment. RESULTS:A complete response was achieved in 26.3% of patients and a partial response in 52.6%. Toxicity was assessed according to the Wieberdink limb toxicity scale. Grade II toxicity was noted in 39.5% of patients, grade III in 50% and grade IV in 10.5%. Toxicity was correlated with the results of a number of clinical and laboratory tests. The toxicity of melphalan and actinomycin D was dose-dependent. For melphalan, the relationship between toxicity and mean dose was as follows: grade II--34.7 mg; grades III and IV--47.5 mg (P = 0.012). The relationship between toxicity and maximum serum creatine phosphokinase (CPK) was as follows: grade II--431.5 U/L; grades III and IV--3228 U/L (P = 0.010). CONCLUSION:Toxicity after ILI is dose-dependent and serum CPK correlates with toxicity.
journal_name
ANZ J Surgjournal_title
ANZ journal of surgeryauthors
Duprat Neto JP,Mauro AC,Molina AS,Nishinari K,Zurstrassen CE,Costa OF,Belfort FA,Facure L,Fregnani JHdoi
10.1111/j.1445-2197.2012.06249.xsubject
Has Abstractpub_date
2014-09-01 00:00:00pages
677-82issue
9eissn
1445-1433issn
1445-2197journal_volume
84pub_type
杂志文章,多中心研究abstract：BACKGROUND:Despite conflicting data regarding oncological outcomes, studies demonstrate that complete mesocolic excision (CME) and central vascular ligation (CVL) for right-sided colon cancer removes significantly more tissue and yields higher lymph node counts when compared to conventional resection. This study aims t...
journal_title：ANZ journal of surgery
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abstract：BACKGROUND:A proportion of patients with acute pancreatitis (AP) develop necrosis. Around a third will become infected, and this is associated with a significant requirement for intervention and support. We evaluated the burden of necrotizing pancreatitis (NP) in an Australian tertiary hospital with regards to morbidit...
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abstract：BACKGROUND:Laparoscopic fundoplication is an effective treatment for gastro-oesophageal reflux disease (GERD). We aimed to assess quality of life (QoL), long-term residual symptoms, patient satisfaction and use of acid-suppression medication at 5, 10 and 20 years after surgery. METHODS:We identified a cohort of 100 pa...
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journal_title：ANZ journal of surgery
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abstract：:It was the achievement of Andreas Vesalius (1514-1564) to redefine the understanding of human anatomy; and that of Homer was to write the first historical novel. This paper offers a link between the works of these two venturers, by way of an examination of the clinical anatomy of the clavicle. ...
journal_title：ANZ journal of surgery
pub_type： 传,历史文章,杂志文章
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journal_title：ANZ journal of surgery
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journal_title：ANZ journal of surgery
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abstract：BACKGROUND:Burns are complex, multifaceted injuries that can pose significant challenges to the treating team. The Royal Adelaide Hospital (RAH) Burns Service has undergone a major evolution over the past two decades, with perceived improvement in outcomes. We present here a longitudinal audit of the RAH Burns Service ...
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abstract：BACKGROUND:Arthroscopic knee surgery has been a topic of significant controversy in recent orthopaedic literature. Multiple studies have used administrative (Victorian Admitted Episodes Dataset and Centre for Health Record Linkage) data to identify trends in practice. This study explored the usage and reporting of arth...
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abstract：BACKGROUND:Open cholecystectomy is still a fairly frequently performed operation worldwide, and is used where laparoscopic surgery has failed or is contraindicated, and where some surgeons do not operate laparoscopically for technical reasons. In developing countries laparoscopic cholecystectomy is costly and is availa...
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doi：10.1046/j.1440-1622.2001.02046.x
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abstract：BACKGROUND:To prevent postoperative hypoparathyroidism following total thyroidectomy, the parathyroid glands are preserved in situ and/or resected or devascularized parathyroid glands are autotransplanted. A retrospective investigation was conducted utilizing biochemical and specific endocrine assessments to evaluate t...
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doi：10.1111/j.1445-2197.2005.03435.x
更新日期：2005-07-01 00:00:00
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abstract：BACKGROUND:Single-incision laparoscopic cholecystectomy (SILC) is a common procedure performed worldwide. In this study, we evaluated the safety and efficacy of SILC for acute cholecystitis. METHODS:Patients who underwent SILC between September 2012 and December 2016 were retrospectively enrolled and divided into acut...
journal_title：ANZ journal of surgery
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更新日期：2016-05-01 00:00:00
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journal_title：ANZ journal of surgery
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更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:To extract from the biomedical published reports, the effects of hyperbaric oxygen (HBO) on inflammatory disease, in particular acute pancreatitis. METHODS:This review will explain these effects and evaluate potential mechanisms of action of HBO in acute pancreatitis. A Medline/PubMed search (January 1966 t...
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更新日期：2006-07-01 00:00:00
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更新日期：2013-04-01 00:00:00
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journal_title：ANZ journal of surgery
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更新日期：2018-09-01 00:00:00
