Abstract:
:Previous studies have supported the hypothesis that macromolecular synthesis occurs in the brain during sleep as a response to prior waking activities and that prostaglandin D2 (PGD2) is an endogenous sleep substance whose effects are dependent on adenosine A2a receptor-mediated signaling. We compared gene expression in the cerebral cortex, basal forebrain, and hypothalamus during PGD2-induced and adenosinergically-induced sleep to results from our previously published study of recovery sleep (RS) after sleep deprivation (SD). Immediate early gene expression in the cortex during sleep induced by PGD2- or by the selective adenosine A2a agonist CGS21680 showed limited similarity to that observed during RS while, in the basal forebrain and hypothalamus, widespread activation of immediate early genes not seen during RS occurred. In all three brain regions, PGD2 and CGS21680 reduced the expression of arc, a transcript whose expression is elevated during SD. Using GeneChips, the majority of genes induced by either PGD2 or CGS21680 were induced by both, suggesting activation of the same pathways. However, gene expression induced in the brain after PGD2 or CGS21680 treatment was distinct from that described during RS after SD and apparently involves glial cell gene activation and signaling pathways in neural-immune interactions.
journal_name
J Neurochemjournal_title
Journal of neurochemistryauthors
Terao A,Huang ZL,Wisor JP,Mochizuki T,Gerashchenko D,Urade Y,Kilduff TSdoi
10.1111/j.1471-4159.2008.05257.xsubject
Has Abstractpub_date
2008-05-01 00:00:00pages
1480-98issue
4eissn
0022-3042issn
1471-4159pii
JNC5257journal_volume
105pub_type
杂志文章abstract::The release of gamma-aminobutyric acid (GABA) was studied in slices of the head of the rabbit caudate nucleus. The slices were preincubated with [3H]GABA and then superfused. Aminooxyacetic acid was present throughout. Both the tritium in the slices and that in the superfusate consisted practically entirely of [3H]GAB...
journal_title:Journal of neurochemistry
pub_type: 杂志文章
doi:10.1111/j.1471-4159.1986.tb00624.x
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journal_title:Journal of neurochemistry
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
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更新日期:2002-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1471-4159.1981.tb00454.x
更新日期:1981-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:1982-05-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
doi:10.1111/j.1471-4159.1993.tb13391.x
更新日期:1993-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:1997-06-01 00:00:00
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pub_type: 评论,社论
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更新日期:2017-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2004-04-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
doi:10.1111/j.1471-4159.1985.tb07191.x
更新日期:1985-06-01 00:00:00
abstract::This study focuses on the potential involvement of carnitine palmitoyltransferase (CPT) on the phospholipid and triglyceride fatty acid turnover in neurons. This category of enzymes, which has been identified in several rat brain tissues, is well known for its role in modulating cellular fatty acid oxidation. Neuronal...
journal_title:Journal of neurochemistry
pub_type: 杂志文章
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更新日期:1994-04-01 00:00:00
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更新日期:1996-03-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
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更新日期:1985-07-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章
doi:10.1046/j.1471-4159.2001.00469.x
更新日期:2001-09-01 00:00:00
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journal_title:Journal of neurochemistry
pub_type: 杂志文章,评审
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更新日期:2010-09-01 00:00:00
abstract::Calsenilin/DREAM/KChIP3 was identified as a calcium-binding protein that interacts with presenilins, serves as a transcription repressor, and binds to the A-type potassium channel. In this study, we hypothesized that calsenilin might be involved in the neurodegeneration of Alzheimer's disease and examined calsenilin e...
journal_title:Journal of neurochemistry
pub_type: 杂志文章
doi:10.1111/j.1471-4159.2004.02159.x
更新日期:2004-02-01 00:00:00