Ethanol-induced aspartate and taurine release from primary astrocyte cultures.

Abstract:

:Exposure of primary astrocyte cultures to isosmotic ethanol from 10-100 mM led to both swelling of the cells and release of [3H]taurine and D-[3H]aspartate. Exposure to hyperosmotic ethanol, in the same concentration range, caused neither swelling nor release. Release was inhibited by the anion transport blocker L-644,711, already shown to inhibit amino acid release evoked by hypoosmotic or high-potassium medium, conditions that also cause astrocytic swelling. Ethanol-induced release generally showed a decline in response to successive exposures to ethanol, and release was not dependent on extracellular calcium. Thus, the characteristics of swelling-induced release of amino acids by isosmotic ethanol seem to correspond to those of swelling-induced release from astrocytes due to exposure to hypotonic or high-K+ media. We discuss whether such effects may contribute to CNS damage after head injury and stroke.

journal_name

J Neurochem

authors

Kimelberg HK,Cheema M,O'Connor ER,Tong H,Goderie SK,Rossman PA

doi

10.1111/j.1471-4159.1993.tb13391.x

subject

Has Abstract

pub_date

1993-05-01 00:00:00

pages

1682-9

issue

5

eissn

0022-3042

issn

1471-4159

journal_volume

60

pub_type

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