Histiocyte-rich reactive lymphoid hyperplasia of the liver: unusual morphologic features.

Abstract:

:Reactive lymphoid hyperplasia (RLH) of the liver is a rare entity and has also been termed nodular lymphoid lesion or pseudolymphoma of the liver. We report a case of hepatic RLH exhibiting unusual histiocyte-rich histologic features in a 47-yr-old woman in conjunction with a renal cell carcinoma. A follow-up computed tomography scan was done 14 months after a right radical nephrectomy for renal cell carcinoma revealed a nodular lesion in segment 5 of the liver. The lesion was interpreted as metastatic renal cell carcinoma or hepatocellular carcinoma based on the history of the patient and radiologic findings. Wedge resection of segment 5 was done with sufficient distance from the mass. Microscopically, the lesion was composed predominantly of peculiar histiocytic proliferation and was characterized by lymphoid aggregates forming a lymphoid follicle with germinal centers. The present case and prior cases reported in the literature suggest that RLH of the liver appear to be a heterogenous group of reactive inflammatory lesions that are often associated with autoimmune disease or malignant tumors.

journal_name

J Korean Med Sci

authors

Park HS,Jang KY,Kim YK,Cho BH,Moon WS

doi

10.3346/jkms.2008.23.1.156

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

156-60

issue

1

eissn

1011-8934

issn

1598-6357

pii

200802156

journal_volume

23

pub_type

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