Expression of TGFbeta family in the developing internal ear of rat embryos.

Abstract:

:In order to investigate the expression patterns of the transforming growth factor (TGF)beta isoforms in the internal ear, an immunohistochemical study of rat embryos was performed. Rat embryos were taken on the 13th, 15th, 17th, and 19th day after conception and their internal ears were immunohistochemically stained against TGF beta1, beta2, and beta3. As a result, the 13-day-old embryo showed a very weak positivity to TGF beta1. After the 15th day of pregnancy, no reactivity to TGF beta1 was defected. Immunoreactivity to TGF beta2 was observed from the 15th day of pregnancy throughout the rest of the period. The ampulla of the semicircular canal and the cochlear duct showed a notably strong immunohistochemical reaction. A strong reaction to TGF beta3 was observed on the 15th day of pregnancy. However, no positive reactions were observed thereafter. A strong immunoreactivity was observed especially on the apical cytoplasms, the surfaces of the epithelial cells, and basement membranes of the cochlear duct, as well as the semicircular canals of the developing internal ear of rat embryo.

journal_name

J Korean Med Sci

authors

Kim HJ,Kang KY,Baek JG,Jo HC,Kim H

doi

10.3346/jkms.2006.21.1.136

keywords:

subject

Has Abstract

pub_date

2006-02-01 00:00:00

pages

136-42

issue

1

eissn

1011-8934

issn

1598-6357

pii

200602136

journal_volume

21

pub_type

杂志文章
  • Acute diffuse phlegmonous esophagogastritis: a case report.

    abstract::Acute phlegmonous infection of the gastrointestinal tract is characterized by purulent inflammation of the submucosa and muscular layer with sparing of the mucosa. The authors report a rare case of acute diffuse phlegmonous esophagogastritis, which was well diagnosed based on the typical chest computed tomographic (CT...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2010.25.10.1532

    authors: Kim HS,Hwang JH,Hong SS,Chang WH,Kim HJ,Chang YW,Kwon KH,Choi DL

    更新日期:2010-10-01 00:00:00

  • Erythropoietin attenuates hyperoxia-induced lung injury by down-modulating inflammation in neonatal rats.

    abstract::This study was done to determine whether recombinant human erythropoietin (rhEPO) treatment could attenuate hyperoxia-induced lung injury, and if so, whether this protective effect is mediated by the down-modulation of inflammation in neonatal rats. Newborn Sprague Dawley rat pups were subjected to 14 days of hyperoxi...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2007.22.6.1042

    authors: Lee JH,Sung DK,Koo SH,Shin BK,Hong YS,Son CS,Lee JW,Chang YS,Park WS

    更新日期:2007-12-01 00:00:00

  • Antidepressant Prescription Patterns in Bipolar Disorder: a Nationwide, Register-based Study in Korea.

    abstract:Background:The role of antidepressants (ADs) in bipolar disorder is long-standing controversial issue in psychiatry. Many clinicians have used ADs as a treatment for bipolar depression, and the selection of therapeutic agents is very diverse and inconsistent. This study aimed to examine recent AD prescription patterns ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2018.33.e290

    authors: Yoon W,Shon SH,Hong Y,Joo YH,Lee JS

    更新日期:2018-10-19 00:00:00

  • Amplification of c-erbB-2 proto-oncogene in cancer foci, adjacent normal, metastatic and normal tissues of human primary gastric adenocarcinomas.

    abstract::Genetic damages are frequently found in both tumor and normal cells at carcinogen exposed areas in the patients with upper aerodigestive tract cancer. These phenomena are explained by the multistage process and/or field cancerization theories. The c-erbB-2 proto-oncogene has been amplified in many human tumors includi...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1997.12.4.311

    authors: Kim JS,Choi CW,Kim BS,Shin SW,Kim YH,Mok YJ,Kim JS,Koo BH

    更新日期:1997-08-01 00:00:00

  • Antitumor activity of TRAIL recombinant adenovirus in human malignant glioma cells.

    abstract::Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL) has been reported to specifically kill malignant cells but to be relatively nontoxic to normal cells. One of disadvantages to previous in vivo protocols was the need for large quantities of TRAIL recombinant protein to suppress tumor growth. To evaluate t...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2005.20.6.1046

    authors: Kim KU,Seo SY,Heo KY,Yoo YH,Kim HJ,Lee HS,Choi SS,Hwang TH,Lee HJ

    更新日期:2005-12-01 00:00:00

  • Effects of pH on vascular tone in rabbit basilar arteries.

    abstract::Effects of pH on vascular tone and L-type Ca2+ channels were investigated using Mulvany myograph and voltage-clamp technique in rabbit basilar arteries. In rabbit basilar arteries, high K+ produced tonic contractions by 11+/-0.6 mN (mean+/-S.E.,n=19). When extracellular pH (pHo) was changed from control 7.4 to 7.9 ([a...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2004.19.1.42

    authors: Kim YC,Lee SJ,Kim KW

    更新日期:2004-02-01 00:00:00

  • Large subcutaneous calcification in systemic lupus erythematosus: treatment with oral aluminum hydroxide administration followed by surgical excision.

    abstract::A 32-year-old woman with a long-standing systemic lupus erythematosus had multiple subcutaneous nodules on her axillae, iliac crests and limbs. Three years ago, these nodules began to appear and slowly became larger. Some of them amassed to form a large, fungating, lobulated mass on her right iliac crest. Roentgenogra...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1999.14.5.589

    authors: Park YM,Lee SJ,Kang H,Cho SH

    更新日期:1999-10-01 00:00:00

  • Correlation between proliferating index and prognostic factors in papillary cystic tumors of the pancreas.

    abstract::Fifteen cases of papillary cystic tumor of the pancreas (PCTP) were studied (14 female patients, one male patient; mean age: 23.5 years). Most tumors developed in the head of the pancreas as a well circumscribed large mass. The tumor had a mean diameter of 6.7 cm(range; 2 to 15 cm). Histopathologically abundant delica...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1995.10.5.342

    authors: Cho NH,Go JH,Jung SH,Jung WH,Lee KK

    更新日期:1995-10-01 00:00:00

  • Added Value of Bone Suppression Image in the Detection of Subtle Lung Lesions on Chest Radiographs with Regard to Reader's Expertise.

    abstract:BACKGROUND:Chest radiographs (CXR) are the most commonly used imaging techniques by various clinicians and radiologists. However, detecting lung lesions on CXR depends largely on the reader's experience level, so there have been several trials to overcome this problem using post-processing of CXR. We investigated the a...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2019.34.e250

    authors: Hong GS,Do KH,Lee CW

    更新日期:2019-10-07 00:00:00

  • Prevalence and Risk Factors of Gastric and Colorectal Cancer after Cholecystectomy.

    abstract:BACKGROUND:Previous studies on the relationship between gastrointestinal (GI) cancer and cholecystectomy remain inconclusive. We aimed to evaluate this relationship, albeit particularly between cholecystectomy and gastric cancer or colorectal cancer (CRC), and the risk factors of cancer among individuals who have under...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2020.35.e354

    authors: Kim SB,Kim KO,Kim TN

    更新日期:2020-11-02 00:00:00

  • Clinical presentations and neurodevelopmental outcomes of perinatal stroke in preterm and term neonates: a case series.

    abstract::Perinatal stroke in neonates can lead to disability in later life. However, its etiology and prognosis are poorly understood. The aim of this study was to describe clinical presentations and neurodevelopmental outcomes of our case series of perinatal stroke in Korea. Thirteen term and preterm neonates who were diagnos...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2010.25.6.888

    authors: Lee HJ,Lim BC,Hwang H,Hong JS,Kim EK,Kim HS,Kim BI,Choi JH,Choi CW

    更新日期:2010-06-01 00:00:00

  • Chronic Intussusception Caused by Diffuse Large B-Cell Lymphoma in a 6-Year-Old Girl Presenting with Abdominal Pain and Constipation for 2 Months.

    abstract::The classical triad of abdominal pain, vomiting, and bloody stool is absent in chronic intussusception for more than 2 weeks. Here, we report a 6-year-old female with recurrent abdominal pain for 2 months. Ultrasonography of the abdomen revealed an ileocolic-type intussusception. The lesion accompanying the tight fibr...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2016.31.2.321

    authors: Choi SH,Han SA,Won KY

    更新日期:2016-02-01 00:00:00

  • Efficacy of dendritic cells matured early with OK-432 (Picibanil), prostaglandin E2, and interferon-alpha as a vaccine for a hormone refractory prostate cancer cell line.

    abstract::Dendritic cells (DCs) are potent antigen-presenting cells. OK432 (Picibanil) was introduced as a potent stimulator of DC maturation in combination with prostaglandin-E(2) and interferon-alpha. We compared the efficacy of a DC-prostate cancer vaccine using early-mature DCs stimulated with OK432, PGE2 and INF-alpha (OPA...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2010.25.9.1284

    authors: Yoo C,Do HA,Jeong IG,Park H,Hwang JJ,Hong JH,Cho JS,Choo MS,Ahn H,Kim CS

    更新日期:2010-09-01 00:00:00

  • Prevalence and risk factors of early-stage age-related macular degeneration in patients examined at a health promotion center in Korea.

    abstract::We evaluated the prevalence and risk factors for early age-related macular degeneration (AMD) in Koreans 50 yr of age or older who were examined at a single health promotion center. We retrospectively reviewed the records of 10,449 subjects who visited the center over a 6-month period. Fundus photography was performed...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2012.27.5.537

    authors: Moon BG,Joe SG,Hwang JU,Kim HK,Choe J,Yoon YH

    更新日期:2012-05-01 00:00:00

  • Association between genetic polymorphisms of CYP2D6 and outcomes in breast cancer patients with tamoxifen treatment.

    abstract::The aim of the study was to evaluate the association between genetic polymorphisms of CYP2D6 and outcomes in breast cancer patients with tamoxifen treatment. We evaluated the CYP2D6 genetic polymorphisms in 766 breast cancer patients. Among them, 110 patients whose samples were prospectively collected before surgery a...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2011.26.8.1007

    authors: Park HS,Choi JY,Lee MJ,Park S,Yeo CW,Lee SS,Shin JG,Park BW

    更新日期:2011-08-01 00:00:00

  • Intravascular papillary endothelial hyperplasia (Masson's hemangioma) of the liver: a new hepatic lesion.

    abstract::Intravascular papillary endothelial hyperplasia (Masson's hemangioma) is a disease characterized by exuberant endothelial proliferation within the lumen of medium-sized veins. In 1923, Masson regarded this disease as a neoplasm inducing endothelial proliferation, however, now it is considered to be a reactive vascular...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2004.19.2.305

    authors: Hong SG,Cho HM,Chin HM,Park IY,Yoo JY,Hwang SS,Kim JG,Park WB,Chun CS

    更新日期:2004-04-01 00:00:00

  • Predictive value of Kushida index and acoustic pharyngometry for the evaluation of upper airway in subjects with or without obstructive sleep apnea.

    abstract::Acoustic pharyngometry is a relatively new noninvasive method that quantifies geometrically complexed pharyngeal dimensions. Our study aimed to investigate the predictability and usefulness of acoustic pharyngometry in diagnosis of obstructive sleep apnea (OSA), and we developed a prospective clinical trial in 16 subj...

    journal_title:Journal of Korean medical science

    pub_type: 临床试验,杂志文章

    doi:10.3346/jkms.2004.19.5.662

    authors: Jung DG,Cho HY,Grunstein RR,Yee B

    更新日期:2004-10-01 00:00:00

  • Comparison of the Mortality and In-Hospital Outcomes of Preterm Infants Treated with Ibuprofen for Patent Ductus Arteriosus with or without Clinical Symptoms Attributable to the Patent Ductus Arteriosus at the Time of Ibuprofen Treatment.

    abstract::The aim of this study was to assess the differences in the mortality and in-hospital outcomes of preterm infants with < 28 weeks of gestation who received ibuprofen treatment according to the presence of clinical symptoms (any of oliguria, hypotension, or moderate to severe respiratory difficulty) attributable to hemo...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2017.32.1.115

    authors: Yoo H,Lee JA,Oh S,Jung YH,Sohn JA,Shin SH,Choi CW,Kim EK,Kim HS,Kim BI

    更新日期:2017-01-01 00:00:00

  • Prevalence of otitis media and allied diseases in Korea--results of a nation-wide survey, 1991.

    abstract::A nation-wide survey was conducted to estimate the prevalence of otitis media and allied diseases through physical examination by otolaryngologic doctors from July to October, 1991. A sample study population was selected from a panel to be representative of the Korean population by multistage clustered and stratified ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1993.8.1.34

    authors: Kim CS,Jung HW,Yoo KY

    更新日期:1993-02-01 00:00:00

  • Hip and Subtrochanteric or Femoral Shaft Fractures after Bisphosphonate Use in Korean Women, Using Korean National Sample Cohort.

    abstract:BACKGROUND:Concern about bisphosphonate-associated subtrochanteric and femoral shaft (ST/FS) fractures has been raised. However, its real risk is still debatable, because there is no study to estimate risk and benefit of bisphosphonate. The objective of this study was to evaluate the risk of typical hip fractures and S...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2020.35.e193

    authors: Won SH,Ahn S,Ji E,Park JW,Kim JK,Lee YK

    更新日期:2020-06-29 00:00:00

  • Differentiation of malignant from benign pancreatic mass by Tl-201 abdominal SPECT.

    abstract::The aim of the present study was to evaluate the ability of Tl-201 abdominal SPECT to differentiate between chronic focal pancreatitis and pancreatic malignancy. Seventeen patients (12 men, 5 women; mean age, 56 years; 9 pancreatic cancer, 8 chronic pancreatitis) with pancreatic mass were prospectively investigated wi...

    journal_title:Journal of Korean medical science

    pub_type: 临床试验,杂志文章

    doi:10.3346/jkms.1995.10.2.93

    authors: Bom HS,Song HC,Kim JY,Choi SK,Rew JS,Yoon CM

    更新日期:1995-04-01 00:00:00

  • Hematopoietic stem cell transplantation in children with leukemia: a single institution experience with respect to donors.

    abstract::Aim of this study was to compare the outcomes of transplantation by donor source and to help select the best alternative donor in children with leukemia. Donor sources included matched related donor (MRD, n = 35), allele-matched unrelated donor (M-UD, n = 10) or -mismatched (MM)-UD (n = 13) or unrelated umbilical cord...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2011.26.12.1548

    authors: Baek HJ,Kook H,Han DK,Hwang TJ

    更新日期:2011-12-01 00:00:00

  • ABCG2 Polymorphism Is Associated with Hyperuricemia in a Study of a Community-Based Korean Cohort.

    abstract::The purpose of the present study was to find novel loci associated with hyperuricemia using data from a genome-wide association study (GWAS) conducted on healthy Koreans. We conducted a GWAS using data from a community-based cohort study where 3,647 subjects aged 40-89 were recruited by the Korea National Institute of...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2017.32.9.1451

    authors: Son CN,Bang SY,Kim SH,Sung YK,Bae SC,Jun JB

    更新日期:2017-09-01 00:00:00

  • Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation.

    abstract::The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P), recently was reported to induce apoptosis of some cancer cells and neurons, although it generally known to exert mitogenic and antiapoptotic effects. In this study, we investigated the effects of S1P on the cell growth, melanogenesis, and apoptosis o...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2007.22.2.298

    authors: Shin JH,Choi GS,Kang WH,Myung KB

    更新日期:2007-04-01 00:00:00

  • Comparison of ertapenem and ceftriaxone therapy for acute pyelonephritis and other complicated urinary tract infections in Korean adults: a randomized, double-blind, multicenter trial.

    abstract::The efficacy and safety of ertapenem, 1 g once daily, were compared with that of ceftriaxone, 2 g once daily, for the treatment of adults with acute pyelonephritis (APN) and complicated urinary tract infections (cUTIs) in a prospective, multicenter, double-blinded, randomized study. After ≥ 3 days of parenteral study ...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.3346/jkms.2012.27.5.476

    authors: Park DW,Peck KR,Chung MH,Lee JS,Park YS,Kim HY,Lee MS,Kim JY,Yeom JS,Kim MJ

    更新日期:2012-05-01 00:00:00

  • Human Urine-derived Stem Cells Seeded Surface Modified Composite Scaffold Grafts for Bladder Reconstruction in a Rat Model.

    abstract::We conducted this study to investigate the synergistic effect of human urine-derived stem cells (USCs) and surface modified composite scaffold for bladder reconstruction in a rat model. The composite scaffold (Polycaprolactone/Pluronic F127/3 wt% bladder submucosa matrix) was fabricated using an immersion precipitatio...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2015.30.12.1754

    authors: Lee JN,Chun SY,Lee HJ,Jang YJ,Choi SH,Kim DH,Oh SH,Song PH,Lee JH,Kim JK,Kwon TG

    更新日期:2015-12-01 00:00:00

  • Impacts of the quinazoline-based alpha1-antagonist, terazosin, and of the sulfonamide derivative, tamsulosin, on serum prostate-specific antigen and prostate volume.

    abstract::The aim of this study was to compare the impacts of terazosin and tamsulosin, on prostate activity, i.e., serum prostate-specific antigen, total prostate volume (TPV), and transition zone volume (TZV). A total of 90 patients who presented with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplas...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2008.23.3.509

    authors: Paick JS,Cho MC,Song SH,Kim SW,Ku JH

    更新日期:2008-06-01 00:00:00

  • Virtual Endoscopic and Laparoscopic Exploration of Stomach Wall Based on a Cadaver's Sectioned Images.

    abstract::We intended to determine that virtual endoscopy and laparoscopy of the stomach based on serially sectioned cadaver images is beneficial. Therefore, the outlines between the gastric wall and lumen were traced using the new female data of the Visible Korean to build a volume model. While the outlines were expanded at ap...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2015.30.5.658

    authors: Kwon K,Shin DS,Shin BS,Park HS,Lee S,Jang HG,Park JS,Chung MS

    更新日期:2015-05-01 00:00:00

  • Characteristics of Children with Acute Carbon Monoxide Poisoning in Ankara: A Single Centre Experience.

    abstract::The purpose of the study was to define characteristics of children with acute carbon monoxide poisoning. Eighty children hospitalized with acute carbon monoxide poisoning were recruited prospectively over a period of 12 months. Sociodemographic features, complaints and laboratory data were recorded. When the patient w...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.2015.30.12.1836

    authors: Unsal Sac R,Taşar MA,Bostancı İ,Şimşek Y,Bilge Dallar Y

    更新日期:2015-12-01 00:00:00

  • Button battery impaction in nasal cavity.

    abstract::A button battery inserted in the nose of children is an unusual foreign body which is capable of causing extensive tissue damage, resulting from electrical and chemical burns. We report a case of button battery in the nose of a 4-year-old boy presenting with unilateral nasal discharge, and necrosis in the septum and t...

    journal_title:Journal of Korean medical science

    pub_type: 杂志文章

    doi:10.3346/jkms.1999.14.2.210

    authors: Kim KK,Kim JR,Kim JY

    更新日期:1999-04-01 00:00:00