Abstract:
:The aim of this study was to assess the differences in the mortality and in-hospital outcomes of preterm infants with < 28 weeks of gestation who received ibuprofen treatment according to the presence of clinical symptoms (any of oliguria, hypotension, or moderate to severe respiratory difficulty) attributable to hemodynamically-significant patent ductus arteriosus (hsPDA) at the time of first ibuprofen treatment. In total, 91 infants born from April 2010 to March 2015 were included. Fourteen infants (15.4%) received ibuprofen treatment when there were clinical symptoms due to hsPDA (clinical symptoms group). In clinical symptoms group, infants were younger (25 [23-27] vs. 26 [23-27] weeks; P = 0.012) and lighter (655 [500-930] vs. 880 [370-1,780] grams; P < 0.001). Also, the clinical risk index for babies (CRIB)-II scores were higher and more infants received invasive ventilator care ≤ 2 postnatal days. More infants received multiple courses of ibuprofen in clinical symptoms group. Although the frequency of secondary patent ductus arteriosus (PDA) ligation and the incidence of bronchopulmonary dysplasia (BPD) was higher in the clinical symptoms group in the univariate analysis, after multivariate logistic regression analysis adjusting for the CRIB-II score, birthweight, birth year, and the invasive ventilator care ≤ 2 postnatal days, there were no significant differences in mortality, frequency of secondary ligation and in-hospital outcomes including necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), BPD or death. Our data suggest that we can hold off on PDA treatment until the clinical symptoms become prominent.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Yoo H,Lee JA,Oh S,Jung YH,Sohn JA,Shin SH,Choi CW,Kim EK,Kim HS,Kim BIdoi
10.3346/jkms.2017.32.1.115subject
Has Abstractpub_date
2017-01-01 00:00:00pages
115-123issue
1eissn
1011-8934issn
1598-6357pii
32.115journal_volume
32pub_type
杂志文章abstract:BACKGROUND:The coronavirus disease 2019 (COVID-19) outbreak has exposed healthcare workers to extreme physical workloads and psychological challenges. Thus, we aimed to assess the immediate correlates of emotional stress and to identify which specific jobs, departments, and exposure types are risk factors for emotional...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2020.35.e372
更新日期:2020-10-26 00:00:00
abstract::Multiple epiphyseal dysplasia is caused by heterogeneous genotypes involving more than six genes. Recessive mutations in the DTDST gene cause a phenotype of recessive multiple epiphyseal dysplasia (rMED). The authors report a 9-yr old Korean girl with the rMED phenotype having novel compound heterozygous mutations in ...
journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1998.13.4.431
更新日期:1998-08-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章,随机对照试验
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abstract::Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy individuals and cancer patients was evaluated. The methylation-variable sites of 14 genes, including ulcer-healing...
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abstract::Four cases of well differentiated lymphocytic lymphoma with or without plasmacytoid differentiation of the lung are described. Two cases were single and the others were multiple. Histologic pictures of the lesion showed mass with perivascular, interstitial and alveolar extension in three cases and only interstitial an...
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doi:10.3346/jkms.1987.2.2.103
更新日期:1987-06-01 00:00:00
abstract::Carcinosarcoma of the adrenal gland is an extremely rare variant of adrenocortical carcinoma, characterized by a biphasic pattern of carcinoma and sarcoma-like components. We report a case of adrenal carcinosarcoma occurring in a 61-year-old Korean man who presented with right flank pain of one month duration radiatin...
journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1997.12.4.374
更新日期:1997-08-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2012.27.10.1273
更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2015.30.3.278
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doi:10.3346/jkms.2008.23.4.635
更新日期:2008-08-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2020.35.e40
更新日期:2020-02-17 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2010.25.12.1754
更新日期:2010-12-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2010.25.11.1669
更新日期:2010-11-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2012.27.2.207
更新日期:2012-02-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.1999.14.6.629
更新日期:1999-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of Korean medical science
pub_type: 临床试验,杂志文章
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更新日期:2004-12-01 00:00:00
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更新日期:2018-07-05 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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更新日期:2010-07-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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journal_title:Journal of Korean medical science
pub_type: 杂志文章,随机对照试验
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更新日期:2017-06-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2006.21.6.1075
更新日期:2006-12-01 00:00:00
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
doi:10.3346/jkms.2019.34.e104
更新日期:2019-04-08 00:00:00