Abstract：
:The purpose of the present study was to find novel loci associated with hyperuricemia using data from a genome-wide association study (GWAS) conducted on healthy Koreans. We conducted a GWAS using data from a community-based cohort study where 3,647 subjects aged 40-89 were recruited by the Korea National Institute of Health (KNIH). The community-based cohort consisted of subjects who did not suffer from any of 6 major diseases (hypertension, hyperlipidemia, diabetes, heart diseases, brain diseases, and cancers). Epidemiologic information includes 249 traits such as epidemiological surveys, physical examinations, and laboratory tests. A total of 3,647 participants, including 234 hyperuricemia cases (serum uric acid [SUA] level was 7 mg/dL or higher) and 3,413 controls, were genotyped by Illumina HumanOmni1-Quad BeadChip GWAS array at KNIH. In the multivariate regression analysis of clinical variables, significant variables associated with hyperuricemia were male gender (odds ratio [OR], 5.526; P = 3.2 × 10⁻¹⁰), old age (OR, 1.017; P = 0.040), high body mass index (BMI) (OR, 1.147; P = 5.4 × 10⁻⁷), current alcohol intake (OR, 2.413; P = 4.7 × 10⁻⁷), and high creatinine (OR, 1.647; P = 1.6 × 10⁻¹³). We identified a hyperuricemia susceptible loci (rs2054576 in ABCG2, OR, 1.883; P = 4.7 × 10⁻⁸) that passed a genome-wide significance threshold, adjusted by clinical variables (male, age, BMI, current alcohol, and creatinine). It was first identified that rs2054576 in ABCG2 is associated with hyperuricemia. Our results should be validated through replication studies among other Korean subjects or various ethnic groups.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Son CN,Bang SY,Kim SH,Sung YK,Bae SC,Jun JBdoi
10.3346/jkms.2017.32.9.1451subject
Has Abstractpub_date
2017-09-01 00:00:00pages
1451-1459issue
9eissn
1011-8934issn
1598-6357pii
32.1451journal_volume
32pub_type
杂志文章abstract：:Cardiac resynchronization therapy (CRT) has been shown to reduce the risk of death and hospitalization in patients with advanced heart failure with left ventricular dysfunction. However, controversy remains regarding who would most benefit from CRT. We performed a meta-analysis, and meta-regression in an attempt to id...
journal_title：Journal of Korean medical science
pub_type： 杂志文章,meta分析,评审
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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abstract：BACKGROUND:Few studies have reported on breakthrough urinary tract infection (UTI) associated with the susceptibility of index UTI to prophylactic antibiotics in children with primary vesicoureteral reflux (VUR) receiving continuous antibiotic prophylaxis (CAP). We assessed the impact of the susceptibility of index UTI...
journal_title：Journal of Korean medical science
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abstract：:It has been reported that the particulate matter under 10 microm (PM10) has deleterious effects on respiratory health. The purpose of this study was to assess the influence of PM10 upon normal children's lung function. The subjects were 368 middle school students in two areas of Incheon Metropolitan City. One (Incheon...
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2018.33.e11
更新日期：2018-01-08 00:00:00
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journal_title：Journal of Korean medical science
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doi：10.3346/jkms.1998.13.6.676
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abstract：:Invasive pulmonary aspergillosis (IPA) is the most frequent form of invasive fungal diseases in immunocompromised patients. However, there are only a few studies on IPA in immunocompromised children in Korea. This study was designed to characterize IPA in Korean children with hematologic/oncologic diseases. Medical re...
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