Abstract:
:The aim of this study was to compare the impacts of terazosin and tamsulosin, on prostate activity, i.e., serum prostate-specific antigen, total prostate volume (TPV), and transition zone volume (TZV). A total of 90 patients who presented with lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH), ranging in age from 52 to 83 yr (median 65 yr), were included in the study. Patients were given 0.2 mg tamsulosin, 2 mg terazosin, or 4 mg terazosin once daily for an average of 14 months (range, 6-56 months). Subjective (International Prostate Symptom Scores, I-PSS) and objective (maximal flow rate and post-void residual) parameters were assessed both at baseline and at treatment cessation. Serum prostate-specific antigen (PSA) levels were found to be unaffected by treatment (1.2 and 1.3 ng/mL). In total patients, multivariate analysis showed that baseline TPV was the only independent predictor of treatment-related TPV reduction. Moreover, baseline TPV > or =30 g was found to be associated with a higher likelihood of TPV reduction (odds ratio [OR], 3.939; 95% confidence interval [CI], 1.506-10.304; p=0.005), and a baseline TZV of > or =10 g was associated with a 7.1-times greater chance of TZV reduction (OR, 7.100; 95% CI, 2.428-20.763; p<0.001). The same model showed that patients on 2 mg terazosin had a 10.8-fold greater likelihood (OR, 10.770; 95% CI, 1.409-82.323; p=0.022) and that those on 4 mg terazosin had a 9.0-fold greater likelihood (OR, 9.001; 95% CI, 1.724-46.995; p=0.009) of a TZV reduction than those on 0.2 mg tamsulosin. In addition, symptoms improved regardless of prostate activity after taking alpha1-blockers. Our findings suggest that terazosin reduces TZV and demonstrate that the relief of symptoms associated with BPH may not be due to a prostate activity reduction induced by apoptosis in the prostate gland.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Paick JS,Cho MC,Song SH,Kim SW,Ku JHdoi
10.3346/jkms.2008.23.3.509subject
Has Abstractpub_date
2008-06-01 00:00:00pages
509-13issue
3eissn
1011-8934issn
1598-6357pii
200806509journal_volume
23pub_type
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pub_type: 已发布勘误
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journal_title:Journal of Korean medical science
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.3346/jkms.2012.27.10.1273
更新日期:2012-10-01 00:00:00
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pub_type: 杂志文章
doi:10.3346/jkms.2006.21.6.1021
更新日期:2006-12-01 00:00:00
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