Nucleolar organizer regions of lymphomas in Korea.

Abstract:

:Nucleolar organizer regions (NORs) are loops of DNA which occur in the nucleoli of cells and which possess ribosomal RNA (rRNA) genes. The numbers and/or configurations of NORs have been thought to be related to cellular activities. To assess the applicability of NORs associated protein (Ag-NORs) in the field of diagnostic histopathology, a silver staining was done in paraffin sections of malignant lymphomas, tonsils and reactive lymph nodes and the numbers of Ag-NORs in the nuclei of low-grade and those of high-grade lymphomas were compared. A significant difference was found between the numbers of Ag-NORs in the nuclei of low-grade lymphoma (a mean of 1.3 per nucleus) and those of high-grade lymphomas (a mean of 4.2 to 8.3 per nucleus). The Ag-NORs were often observed in nuclei in areas where nucleoli themselves were not visible in H&E stain. It is suggested that this method would be of great value in the field of tumor histopathology.

journal_name

J Korean Med Sci

authors

Kim I,Park SH,Paik SY

doi

10.3346/jkms.1988.3.3.99

subject

Has Abstract

pub_date

1988-09-01 00:00:00

pages

99-105

issue

3

eissn

1011-8934

issn

1598-6357

journal_volume

3

pub_type

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