Abstract：
:Genetic damages are frequently found in both tumor and normal cells at carcinogen exposed areas in the patients with upper aerodigestive tract cancer. These phenomena are explained by the multistage process and/or field cancerization theories. The c-erbB-2 proto-oncogene has been amplified in many human tumors including breast, stomach, kidney and lung cancers. To study the possible evidence of multistage process and/or field cancerization in the development of gastric adenocarcinoma, the amplification statuses of c-erbB-2 proto-oncogene using the Southern hybridization technique were evaluated at the 45 gastric adenocarcinoma specimen sets consisting of tumor tissue, adjacent normal tissue (within 2 cm of the primary tumor), metastatic tissue and normal stomach tissue (at least 5 cm away from primary tumor). As a result, c-erbB-2 proto-oncogene at 2 specimen sets (4.4%) was amplified 2- to 4-fold to normal control status. In these 2 cases, c-erbB-2 proto-oncogene at histologically normal tissue adjacent to tumor tissue was amplified. And, the metastatic tissue of 1 case also exhibited c-erbB-2 proto-oncogene amplification of which the degree was less than that of tumor tissue. From these results, we were able to suspect that c-erbB-2 proto-oncogene amplification in the normal tissue adjacent to tumor tissue could be a biomarker of premalignant changes in a small proportion of gastric adenocarcinoma patients. And, this result might suggest the possible role of multistage process and/or field cancerization in the development of gastric adenocarcinoma.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Kim JS,Choi CW,Kim BS,Shin SW,Kim YH,Mok YJ,Kim JS,Koo BHdoi
10.3346/jkms.1997.12.4.311subject
Has Abstractpub_date
1997-08-01 00:00:00pages
311-5issue
4eissn
1011-8934issn
1598-6357journal_volume
12pub_type
杂志文章abstract：:Central obesity has been reported as a risk for atherosclerosis and metabolic syndrome. The influence of central obesity on diurnal blood pressure (BP) has not been established. In this study, we investigated the influence of central obesity on the circadian parameters of BP by 24 hr ambulatory BP monitoring. Total 1,...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2013.28.10.1461
更新日期：2013-10-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1997.12.2.143
更新日期：1997-04-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2010.25.7.1005
更新日期：2010-07-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1995.10.4.287
更新日期：1995-08-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2021.36.e6
更新日期：2021-01-11 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2007.22.1.149
更新日期：2007-02-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2009.24.3.461
更新日期：2009-06-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章,评审
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2002.17.4.468
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1992.7.2.170
更新日期：1992-06-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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journal_title：Journal of Korean medical science
pub_type： 杂志文章,随机对照试验,收录出版
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更新日期：2014-11-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2002.17.2.279
更新日期：2002-04-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2007.22.4.629
更新日期：2007-08-01 00:00:00
abstract：:[This corrects the article on p. 1308 in vol. 29, PMID: 25246752.]. ...
journal_title：Journal of Korean medical science
pub_type： 已发布勘误
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更新日期：2015-01-01 00:00:00
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journal_title：Journal of Korean medical science
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更新日期：2017-10-01 00:00:00
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journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2012.27.3.285
更新日期：2012-03-01 00:00:00
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journal_title：Journal of Korean medical science
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