Abstract：
BACKGROUND:Previous studies on the relationship between gastrointestinal (GI) cancer and cholecystectomy remain inconclusive. We aimed to evaluate this relationship, albeit particularly between cholecystectomy and gastric cancer or colorectal cancer (CRC), and the risk factors of cancer among individuals who have undergone cholecystectomy in Korea. METHODS:In total, 4,222 patients who underwent laparoscopic or open cholecystectomy at our institution between January 2006 and December 2013 were included. Patients who underwent cholecystectomy for gallbladder cancer or were undergoing surgery for GI, hepatic, or pancreatobiliary cancers were excluded, as were those who developed stomach cancer or CRC within a year of their cholecystectomy. The included patients were followed until July 20, 2020. The standardized incidence ratio (SIR) was used to calculate the relative risk of GI cancer in cholecystectomy patients. RESULTS:The median patient age (n = 3,588) at the time of cholecystectomy was 54.0 (range, 19-95) years, and the male-to-female ratio was 1:1.04. The median follow-up period after cholecystectomy was 15.0 (range, 0-146) months. We found a 108% greater risk of CRC (SIR, 2.08; 95% confidence interval [CI], 1.28-3.17) and 154% increased risk of CRC in females (SIR, 2.54; 95% CI, 1.16-4.84). Based on multivariate analysis, an age of > 60 years was a significant risk factor for GI cancer in cholecystectomy patients. CONCLUSION:Cholecystectomy may increase risk of CRC, especially in females. Age was considered a risk factor of GI cancers in patients with history of cholecystectomy.
journal_name
J Korean Med Scijournal_title
Journal of Korean medical scienceauthors
Kim SB,Kim KO,Kim TNdoi
10.3346/jkms.2020.35.e354subject
Has Abstractpub_date
2020-11-02 00:00:00pages
e354issue
42eissn
1011-8934issn
1598-6357pii
35.e354journal_volume
35pub_type
杂志文章abstract：Background:The zoonotic disease Q fever is caused by Coxiella burnetii and usually affects high-risk human populations. We conducted a serological survey of dairy cattle farmers in Korea to determine seroreactivity and identify risk factors for C. burnetii infection. Methods:This cross-sectional study included 1,824 o...
journal_title：Journal of Korean medical science
pub_type： 杂志文章
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journal_title：Journal of Korean medical science
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journal_title：Journal of Korean medical science
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.1992.7.3.214
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journal_title：Journal of Korean medical science
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journal_title：Journal of Korean medical science
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
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journal_title：Journal of Korean medical science
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journal_title：Journal of Korean medical science
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pub_type： 临床试验,杂志文章
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更新日期：2004-10-01 00:00:00
abstract：:The purpose of the current study was to propose a Korean-specific parameter set for calculating the risk of Down syndrome in the second trimester of pregnancy and to determine the screening performances of triple and quadruple tests in Korean women. Using the data on triple or quadruple screening from three hospitals ...
journal_title：Journal of Korean medical science
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doi：10.3346/jkms.2011.26.12.1619
更新日期：2011-12-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2006.21.3.406
更新日期：2006-06-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2000.15.3.289
更新日期：2000-06-01 00:00:00
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journal_title：Journal of Korean medical science
pub_type： 杂志文章
doi：10.3346/jkms.2001.16.1.119
更新日期：2001-02-01 00:00:00
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doi：10.3346/jkms.2020.35.e301
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pub_type： 杂志文章,实务指引
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journal_title：Journal of Korean medical science
pub_type： 杂志文章,评审
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abstract：:Low quality clinical trials have a possibility to have errors in the process of deriving the results and therefore distort the study. Quality assessment of clinical trial is necessary in order to prevent any clinical application erroneous results is important. Randomized controlled trial (RCT) is a design for evaluate...
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