Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation.

abstract：:NAD(P)H oxidase plays an important role in hypertension and its complication in aldosterone-salt rat. We questioned whether NAD(P)H oxidase subunit expression and activity are modulated by aldosterone and whether this is associated with target-organ damage. Rats were infused with aldosterone (0.75 microg/hr/day) for 6...

journal_title：Journal of Korean medical science

authors： Park YM,Lim BH,Touyz RM,Park JB

更新日期：2008-12-01 00:00:00

abstract：:p21 protein has been reported to be a critical downstream effector of p53 and a potent inhibitor of cyclin-dependent kinases. Thus, the p21 gene is thought to play a central role in tumor suppression. In this study we investigated p21 protein expression and mutation in gastric adenocarcinoma. A total of 76 primary gas...

journal_title：Journal of Korean medical science

authors： Park YE,Choi KC,Choi YH

更新日期：1998-10-01 00:00:00

abstract：BACKGROUND:Endoscopic diagnosis of atrophic gastritis can contribute to risk stratification and thereby tailored screening for gastric cancer. We aimed to evaluate the effect of training on inter-observer agreement in diagnosis and grading of endoscopic atrophic gastritis (EAG) according to the level of endoscopists' e...

journal_title：Journal of Korean medical science

authors： Jin EH,Chung SJ,Lim JH,Chung GE,Lee C,Yang JI,Kim JS

更新日期：2018-04-09 00:00:00

abstract：:A patient with renal cell carcinoma (RCC) developed synchronous bone metastasis with metachronous relapses to the bone and renal fossa. The primary lesion was initially removed surgically, and the metastatic bone lesions and locally recurrent tumours were treated by a high-fractional dose and high-total-dose intensity...

journal_title：Journal of Korean medical science

authors： Cho J,Kim GE,Rha KH,Ahn JB,Lee CG,Suh CO,Seong J,Keum KC,Kim SIe,Lee YH

更新日期：2008-08-01 00:00:00

abstract：:Perinatal stroke in neonates can lead to disability in later life. However, its etiology and prognosis are poorly understood. The aim of this study was to describe clinical presentations and neurodevelopmental outcomes of our case series of perinatal stroke in Korea. Thirteen term and preterm neonates who were diagnos...

journal_title：Journal of Korean medical science

authors： Lee HJ,Lim BC,Hwang H,Hong JS,Kim EK,Kim HS,Kim BI,Choi JH,Choi CW

更新日期：2010-06-01 00:00:00

abstract：:This study was to clarify whether Behcet's disease (BD) could be classified into the spondyloarthropathy (SpA) complex. It was undertaken on 58 patients with BD (BD group), 56 patients with SpA (SpA group), and 3 patients who concurrently satisfied the criteria for BD and SpA (BDSpA group). The clinical parameters and...

journal_title：Journal of Korean medical science

authors： Chang HK,Lee DH,Jung SM,Choi SJ,Kim JU,Choi YJ,Baek SK,Cheon KS,Cho EH,Won KS

更新日期：2002-08-01 00:00:00

abstract：:There have been numerous reports on the relationship between eosinophilia and toxocariasis. The present study investigated seropositive rates of toxocariasis among healthy people with or without eosinophilia in urban and rural areas, and assessed risk factors for positive antibody test. A total of 610 healthy people, ...

journal_title：Journal of Korean medical science

authors： Kim HS,Jin Y,Choi MH,Kim JH,Lee YH,Yoon CH,Hwang EH,Kang H,Ahn SY,Kim GJ,Hong ST

更新日期：2014-12-01 00:00:00

abstract：:Allergen-specific immunotherapy (SIT) reduces allergen specific IgE (sIgE) levels and achieves clinical and immunological tolerance by modulating innate and adaptive immunological responses. Increased temperature and CO2 concentrations caused by climate changes contribute to an increase of pollen count and allergenici...

journal_title：Journal of Korean medical science

authors： Kim MA,Yoon MG,Jin HJ,Shin YS,Park HS

更新日期：2014-07-01 00:00:00

abstract：:The objective of this study was to evaluate the prevalence of asthma, allergic rhinitis, and atopic dermatitis, as well as the risk factors of wheezing among young adults in the Korean military. Young military conscripts in five areas completed a modified International Study of Asthma and Allergies in Childhood (ISAAC...

journal_title：Journal of Korean medical science

authors： Lee SM,Ahn JS,Noh CS,Lee SW

更新日期：2011-02-01 00:00:00

abstract：:We aimed to elucidate the effect of bilirubin on dyslipidemia and nephropathy in a diabetes mellitus (DM) type I animal model. Sprague-Dawley rats were separated into control, DM, and bilirubin-treated DM (Bil) groups. The Bil group was injected intraperitoneally with 60 mg/kg bilirubin 3 times per week and hepatoma c...

journal_title：Journal of Korean medical science

authors： Xu J,Lee ES,Baek SH,Ahn SY,Kim S,Na KY,Chae DW,Chin HJ

更新日期：2014-09-01 00:00:00

abstract：:Recommended infant vaccination in Korea includes DTaP-IPV and Hib vaccines administered as separate injections. In this randomized, open, controlled study we assessed the non-inferiority of immunogenicity of DTaP-IPV//Hib pentavalent combination vaccine (Pentaxim™) compared with licensed DTaP-IPV and Hib (PRP~T) vacci...

journal_title：Journal of Korean medical science

authors： Kang JH,Lee HJ,Kim KH,Oh SH,Cha SH,Lee J,Kim NH,Eun BW,Kim CH,Hong YJ,Kim HH,Lee KY,Kim YJ,Cho EY,Kim HS,Guitton F,Ortiz E

更新日期：2016-09-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is an autosomal recessive disorder, caused by homozygous absence of the survival motor neuron gene (SMN1) in approximately 94% of patients. Since most carriers have only one SMN1 gene copy, several SMN1 quantitative analyses have been used for the SMA carrier detection. We developed a rel...

journal_title：Journal of Korean medical science

authors： Lee TM,Kim SW,Lee KS,Jin HS,Koo SK,Jo I,Kang S,Jung SC

更新日期：2004-12-01 00:00:00

abstract：:Low quality clinical trials have a possibility to have errors in the process of deriving the results and therefore distort the study. Quality assessment of clinical trial is necessary in order to prevent any clinical application erroneous results is important. Randomized controlled trial (RCT) is a design for evaluate...

journal_title：Journal of Korean medical science

authors： Chung JH,Kang DH,Jo JK,Lee SW

更新日期：2012-09-01 00:00:00

abstract：:The hepatitis A virus (HAV) has been the leading cause of viral hepatitis in Korea since the 2000s. We aimed to describe the current status and regional differences in hepatitis A incidence. We studied the total number of hepatitis A cases reported to the Korea Centers for Disease Control and Prevention through the Na...

journal_title：Journal of Korean medical science

authors： Moon S,Han JH,Bae GR,Cho E,Kim B

更新日期：2016-01-01 00:00:00

abstract：:Blood-borne metastatic involvement of the stomach by cancer is a rare entity. According to the number of reports in the literature, the most common tumors that spread to the stomach through the blood stream are malignant melanoma, breast carcinoma and lung carcinoma. Recently, two cases of metastatic involvement of th...

journal_title：Journal of Korean medical science

authors： Kim HS,Jang WI,Hong HS,Lee CI,Lee DK,Yong SJ,Shin KC,Shim YH

更新日期：1993-02-01 00:00:00

abstract：:1) A beta agonist stimulated Na+ transport and decreased the intracellular Cl concentration ([Cl]c) associated with cell shrinkage via an increase in cytosolic cAMP level by activating adenylate cyclase in rat fetal distal lung epithelial (FDLE) cells. 2) Lowering [Cl-]c activated a 28-pS nonselective cation (NSC) cha...

journal_title：Journal of Korean medical science

authors： Marunaka Y,Niisato N,Ito Y

更新日期：2000-08-01 00:00:00

abstract：:This study was performed to investigate the etiologic agents, age distribution, clinical manifestations and seasonal occurrence of acute viral lower respiratory tract infections in children. We confirmed viral etiologies using nasopharyngeal aspirates in 237 patients of the ages of 15 years or younger who were hospita...

journal_title：Journal of Korean medical science

authors： Ahn KM,Chung SH,Chung EH,Koh YJ,Nam SY,Kim JH,Son JA,Park JY,Lee NY,Lee SI

更新日期：1999-08-01 00:00:00

abstract：:Atherosclerotic renal artery stenosis (RAS) usually involves the ostium and the proximal one-third of the renal artery main branch. Percutaneous renal artery angioplasty with stent placement is a well recognized treatment for atherosclerotic RAS. Occasionally, atherosclerotic RAS involves renal artery bifurcations. Ho...

journal_title：Journal of Korean medical science

authors： Ahn J,Park SH,Shin WY,Lee SW,Lee SJ,Jin DK,Kim D,Kim TH

更新日期：2011-11-01 00:00:00

abstract：:The purpose of the current study was to propose a Korean-specific parameter set for calculating the risk of Down syndrome in the second trimester of pregnancy and to determine the screening performances of triple and quadruple tests in Korean women. Using the data on triple or quadruple screening from three hospitals ...

journal_title：Journal of Korean medical science

authors： Kwon JY,Park IY,Park YG,Lee Y,Lee G,Shin JC

更新日期：2011-12-01 00:00:00

abstract：:Despite rapid increase in incidence of prostate cancer (PC) and PC survivors, there are few studies regarding competing causes of death and time trends in Asian population. We conducted a cohort study of 2% nationwide random sample of Korean National Health Insurance employees. A total of 873 patients who had received...

journal_title：Journal of Korean medical science

authors： Park J,Suh B,Shin DW,Hong JH,Ahn H

更新日期：2016-11-01 00:00:00

abstract：:Initially, acute loss of smell (anosmia) and taste (ageusia) was not considered important symptoms for coronavirus disease 2019 (COVID-19). To determine the prevalence of these symptoms and to evaluate their diagnostic significance, we (approximately 150 physicians of the Daegu Medical Association) prospectively colle...

journal_title：Journal of Korean medical science

authors： Lee Y,Min P,Lee S,Kim SW

更新日期：2020-05-11 00:00:00

abstract：:This study was conducted to evaluate the effectiveness and safety of a practical protocol for titrating positive end-expiratory pressure (PEEP) involving recruitment maneuver (RM) and decremental PEEP. Seventeen consecutive patients with acute lung injury who underwent PEEP titration were included in the analysis. Aft...

journal_title：Journal of Korean medical science

authors： Suh GY,Kwon OJ,Yoon JW,Park SJ,Ham HS,Kang SJ,Koh WJ,Chung MP,Kim HJ

更新日期：2003-06-01 00:00:00

abstract：:Neonatal sepsis remains one of the most important causes of death and co-morbidity in very-low-birth-weight (VLBW) infants. The aim of this study was to determine the current incidences of early-onset sepsis (EOS) and late-onset sepsis (LOS), the distribution of pathogens, and the impact of infection on co-morbidities...

journal_title：Journal of Korean medical science

authors： Lee SM,Chang M,Kim KS

更新日期：2015-10-01 00:00:00

abstract：:Scleroderma (SSc) renal crisis has been reported to be associated with anti-RNA polymerase I and III (RNAP I/III) antibodies in Caucasians and the Japanese. However, no report is available for Korean SSc patients. Here, we describe the case of a 65-yr-old female SSc patient who developed renal crisis and whose serum c...

journal_title：Journal of Korean medical science

authors： Kang EH,Im CH,Kim SH,Chung JR,Lee EY,Kim DJ,Lee EB,Song YW

更新日期：2006-12-01 00:00:00

abstract：:The purpose of the study was to define characteristics of children with acute carbon monoxide poisoning. Eighty children hospitalized with acute carbon monoxide poisoning were recruited prospectively over a period of 12 months. Sociodemographic features, complaints and laboratory data were recorded. When the patient w...

journal_title：Journal of Korean medical science

authors： Unsal Sac R,Taşar MA,Bostancı İ,Şimşek Y,Bilge Dallar Y

更新日期：2015-12-01 00:00:00

abstract：:Adult intussusception is rare, and the majority of cases has an underlying cause that requires surgical resection. We report a case of a 39 yr-old man with ileo-ileo-colic intussusception caused by ileal lipoma that was successfully managed by a laparoscopic-assisted surgical maneuver. Using a three-cannula technique,...

journal_title：Journal of Korean medical science

authors： Park KT,Kim SH,Song TJ,Moon HY

更新日期：2001-02-01 00:00:00

abstract：:Congenital insensitivity to pain with anhidrosis (CIPA) is a very rare genetic disorder of the peripheral nervous system characterized by recurrent episodes of unexplained fever, generalized anhidrosis, insensitivity to pain and temperature, and accompanied by self-mutilating behavior and mental retardation. We report...

journal_title：Journal of Korean medical science

authors： Kim JS,Woo YJ,Kim GM,Kim CJ,Ma JS,Hwang TJ,Lee MC

更新日期：1999-08-01 00:00:00

abstract：:In some patients, eosinophilic gastroenteritis(EG) occurs in those with food allergy. We experienced a non-atopic asthmatic who had an EG associated with food allergy to fish and eggs, and blood eosinophilia. A skin prick test and RAST to causative food allergens showed a negative result. A fiber-optic endoscopic biop...

journal_title：Journal of Korean medical science

authors： Park HS,Kim HS,Jang HJ

更新日期：1995-06-01 00:00:00

abstract：:In this cross-sectional study, we aimed to identify distinguishing factors between populations with suicidal ideation recruited from hospitals and communities to make an efficient allocation of limited anti-suicidal resources according to group differences. We analyzed the baseline data from 120 individuals in a commu...

journal_title：Journal of Korean medical science

authors： Park CHK,Lee JW,Lee SY,Moon J,Shim SH,Paik JW,Kim SG,Cho SJ,Kim MH,Kim S,Park JH,You S,Jeon HJ,Ahn YM

更新日期：2017-09-01 00:00:00

abstract：:Previous epidemiologic studies have shown the clinical association between non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease (CVD). However, there is only limited information about the effect of NAFLD on the development of hypertension. Accordingly, we investigated the clinical association between N...

journal_title：Journal of Korean medical science

authors： Ryoo JH,Ham WT,Choi JM,Kang MA,An SH,Lee JK,Shin HC,Park SK

更新日期：2014-07-01 00:00:00