Malignant inverted papilloma of the urinary bladder: the histopathological aspect of malignant potential of inverted papilloma.

Abstract:

:To investigate the histopathological characteristics of inverted papillomas of the urinary bladder, including the possibility of malignant transformation, we studied the indicators of cellular proliferation activity in 7 inverted papillomas of the bladder including two cases of malignant inverted papilloma of the bladder. PCNA expression rates in two cases of malignant inverted papilloma were higher than in benign inverted papillomas. Mean numbers of AgNORs per nucleus in malignant inverted papillomas were much more than in benign inverted papillomas. The c-erbB-2 oncoprotein was expressed only in malignant inverted papillomas. These results suggest that PCNA expression rate, mean number of AgNORs per nucleus and c-erB-2 oncoprotein expression may be merited as good indicators to detect the inverted papilloma with more proliferative and aggressive lesions, and with the potential of malignant transformation.

journal_name

J Korean Med Sci

authors

Cheon J,Kim HK,Kim JJ,Yoon DK,Koh SK,Kim IS

doi

10.3346/jkms.1995.10.2.103

subject

Has Abstract

pub_date

1995-04-01 00:00:00

pages

103-10

issue

2

eissn

1011-8934

issn

1598-6357

journal_volume

10

pub_type

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