RNA base damage and repair.

abstract：BACKGROUND:To date, an increasing number of pet owners, especially in the USA, are using cannabis-derived products containing generally delta 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) to help their animals' health. Unfortunately, studies on the clinical use of cannabinoids in veterinary medicine are still limi...

journal_title：Current pharmaceutical biotechnology

authors： Rotolo MC,Graziano S,Pellegrini M,Corlazzoli D,Antinori L,Porcarelli L,Pichini S

更新日期：2017-01-01 00:00:00

abstract：:Recent technological advances in NMR methods and instrumentation are having a significant impact in structural biology. These innovations are also impacting pharmaceutical biotechnology as it is now possible to use NMR spectroscopy to rapidly characterize a growing number of prospective protein drugs and protein drug ...

journal_title：Current pharmaceutical biotechnology

authors： Wishart D

更新日期：2005-04-01 00:00:00

abstract：:The growing prevalence of disorders of lipid and sterol homeostasis such as obesity and atherosclerosis in Western societies has increased demand for the development of therapies for their prevention and treatment. Crucial for this development is an understanding of the underlying cellular mechanisms which are involve...

journal_title：Current pharmaceutical biotechnology

authors： Traini M,Jessup W

更新日期：2012-02-01 00:00:00

abstract：:Staphylococcus aureus is a leading causative agent in sepsis, endocarditis, and pneumonia. An emerging concept is that prognosis worsens when the infecting S. aureus strain has the capacity to not only colonize tissue as an extracellular pathogen, but to invade host cells and establish intracellular bacterial populati...

journal_title：Current pharmaceutical biotechnology

authors： Cordero D,Fullenkamp CR,Pelly RR,Reed KM,Caffo LM,Zahrt AN,Newman M,Komanapalli S,Niemeier EM,Bishop DL,Bruns HA,Haynes MK,Sklar LA,Sammelson RE,McDowell SA

更新日期：2014-01-01 00:00:00

abstract：:Recent research has shown that the endogenous gas hydrogen sulphide (H2S) is a signalling molecule of considerable biological potential and has been suggested to be involved in a vast number of physiological processes. In the vascular system, H2S is synthesized from cysteine by cystathionine-γ-lyase (CSE) in smooth mu...

journal_title：Current pharmaceutical biotechnology

authors： Skovgaard N,Gouliaev A,Aalling M,Simonsen U

更新日期：2011-09-01 00:00:00

abstract：:Acute myeloid leukemia (AML) is characterized as a heterogeneous disease where the patients are sub grouped according to several classification systems and mutational analyses. Diagnosis of AML is based on identification of the specific myeloid cell initiating the disease, quantification of immature blasts in bone mar...

journal_title：Current pharmaceutical biotechnology

authors： Forthun RB,Hinrichs C,Dowling TH,Bruserud Ø,Selheim F

更新日期：2016-01-01 00:00:00

abstract：:Comprehensive analytical technologies are rapidly becoming a cornerstone of modern nutritional sciences. Two of these technologies, mass spectrometry (MS) and nuclear magnetic resonance (NMR), have proven highly informative for the global analysis of metabolites, commonly referred to as metabolomics. Metabolomics prov...

journal_title：Current pharmaceutical biotechnology

authors： Zulyniak MA,Mutch DM

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Burn is still an important global public health challenge. Wound colonization of antibiotic resistant bacteria such as Acinetobacter baumannii can lead to high morbidity and mortality in burn patients. The aim of this study was to evaluate the inhibitory effect of tazobactam on efflux pump, which can cause a...

journal_title：Current pharmaceutical biotechnology

authors： Azimi L,Tahbaz SV,Alaghehbandan R,Alinejad F,Lari AR

更新日期：2020-01-01 00:00:00

abstract：:Plants are rich in a wide variety of secondary metabolites with antimicrobial properties. Phytochemistry studies on the plants extracts in general, and on essential oils (EOs) in particular are focused on the isolation and identification of the components of complex mixtures, in order to determine structure - activity...

journal_title：Current pharmaceutical biotechnology

authors： Saviuc CM,Drumea V,Olariu L,Chifiriuc MC,Bezirtzoglou E,Lazăr V

更新日期：2015-01-01 00:00:00

abstract：:Bone grafts are widely used for augmentation procedures in oral and maxillofacial surgery, with autogenous bone being the gold standard. Recently, the focus of research has shifted towards synthetic bone substitutes, as no second surgery is needed and large quantities of graft can easily be provided. Within the broad ...

journal_title：Current pharmaceutical biotechnology

authors： Gotz W,Papageorgiou SN

更新日期：2017-01-01 00:00:00

abstract：:The bioethical and juridical debate on the status of frozen embryos sometimes adds new issues arising from new scientific evidence or by accidental occurrences that bring to the attention of the scientific community the need for new practical solutions. Within this scenario, there have been, in recent years, episodes ...

journal_title：Current pharmaceutical biotechnology

authors： Busardò FP,Vergallo GM,Turillazzi E,Bolino G,Vullo A,Frati P

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Alfalfa and red clover are the most widespread and most important perennial legumes, primarily used as a high-quality feed for livestock. Both alfalfa and red clover, as well as some other plant species from Fabaceae family, are a rich natural source of phytoestrogens, nonsteroidal compounds with an estrogen...

journal_title：Current pharmaceutical biotechnology

authors： Tucak M,Horvat D,Cupic T,Krizmanic G,Tomas V,Ravlic M,Popovic S

更新日期：2018-01-01 00:00:00

abstract：:MicroRNAs are small non-coding RNA molecules which do not code for proteins, but control the expression of a significant proportion of the genome. The microRNA expression differences of normal and malignant tissue, as well as the differences in various tumor entities qualify this RNA species as biomarker for cancer pa...

journal_title：Current pharmaceutical biotechnology

authors： Ellinger J,Muller SC

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Secondary metabolites of plants, the polyphenols, play a vital role in protection from many health problems in human beings. Structurally favored phytochemicals may be studied to protect multiorgan injury. At pharmacological doses, gallic acid is nontoxic to mammals and is generally absorbed in the intestine...

journal_title：Current pharmaceutical biotechnology

authors： Rakshit S,Nirala SK,Bhadauria M

更新日期：2020-01-01 00:00:00

abstract：:Signals relayed through G protein-coupled receptors (GPCR) play pivotal roles in human physiology and are important drug targets. About 40% of all GPCRs couple to the heterotrimeric G protein Gq. Biochemical studies as well as crystallography have improved our understanding of GqPCRs and their downstream partners. Her...

journal_title：Current pharmaceutical biotechnology

authors： Jalink K,Adjobo-Hermans MJ

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Connexin (Cx) proteins are the building blocks of gap junctions. Among these, Cx37 and Cx40 are expressed on vascular system and reported to have cardioprotective role. Linking polymorphisms in genes coding for Cx and coronary artery disease (CAD) risk showed conflicting results in different populations. Non...

journal_title：Current pharmaceutical biotechnology

authors： El Tahry FA,Hashad IM,Abdel Rahman MF,Gad MZ

更新日期：2017-11-10 00:00:00

abstract：BACKGROUND:Recombinant monoclonal antibodies (mAbs) are useful in research, diagnosis, and therapy. The increased demands of recombinant mAbs require efficient production systems. A variety of expression vectors have been developed for stable or transient production of mAbs in mammalian cells. Although a few commercial...

journal_title：Current pharmaceutical biotechnology

authors： Zhang G,Liu J,Fan W,Chen Q,Shi B

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND & OBJECTIVE:Nutritional culturomics (NCs) is a specific focus area of culturomics epistemology developing digital humanities and computational linguistics approaches to search for macro-patterns of public interest in food, nutrition and diet choice as a major component of cultural evolution. Cultural evoluti...

journal_title：Current pharmaceutical biotechnology

authors： Troumbis AY,Hatziantoniou M,Vasios GK

更新日期：2019-01-01 00:00:00

abstract：:More than 80% of all cancers are caused by solid malignancies. More than 90% of these tumours are of epithelial origin. The main principles in tumour treatment are surgery, radiotherapy, chemotherapy or combinations of these. Complete surgical removal of the tumour is the most effective therapy for solid malignancies....

journal_title：Current pharmaceutical biotechnology

authors： Mauerer R,Gruber R

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Oxymatrine is one of the most promising alkaloids from Sophora flavescens for its excellent pharmacological effects. OBJECTIVE:The aim of this research is to assess the biopharmaceutical and pharmacokinetic activities of oxymatrine, and clarify its mechanisms of absorption and metabolism. METHODS:The biolo...

journal_title：Current pharmaceutical biotechnology

authors： Wang HQ,Chen FH,Wang L,Chi LQ,Wang GH

更新日期：2021-01-18 00:00:00

abstract：:Progress in many therapies, in particular in the therapies based on peptides, proteins and nucleic acids used as bioactive compounds, strongly depends on development of appropriate carriers which would be suitable for controlled delivery of the intact abovementioned compounds to required tissues, cells and intracellul...

journal_title：Current pharmaceutical biotechnology

authors： Slomkowski S,Gosecki M

更新日期：2011-11-01 00:00:00

abstract：:The innate immune system protects against infectious microbes by the recognition of pathogen- associated molecular patterns, which serve to detect pathogens on the host cell surface or in endosomes by pattern recognition receptors such as Toll-like receptors, nucleotide-binding oligomerization domain-containing protei...

journal_title：Current pharmaceutical biotechnology

authors： Fischer S

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The present limitations related to the ocular administration of antifungal drugs for the treatment of fungal keratitis include poor ocular bioavailability, limited retention time, and low ocular tissues penetration. METHODS:This study aimed to prepare a novel ophthalmic voriconazole-loaded nanosuspension ba...

journal_title：Current pharmaceutical biotechnology

authors： Qin T,Dai Z,Xu X,Zhang Z,You X,Sun H,Liu M,Zhu H

更新日期：2020-08-20 00:00:00

abstract：BACKGROUND:Bacterial lipases especially Pseudomonas lipases are extensively used for different biotechnological applications. OBJECTIVES:With the better understanding and progressive needs for improving its activity in accordance with the growing market demand, we aimed in this study to improve the recombinant product...

journal_title：Current pharmaceutical biotechnology

authors： El-Aziz AMA,Shaker MA,Shaaban MI

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Alternative medicine is available for those diseases which cannot be treated by conventional medicine. Ayurveda and herbal medicines are important alternative methods in which the treatment is done with extracts of different medicinal plants. This work is concerned with the evaluation of anti-stress bioactiv...

journal_title：Current pharmaceutical biotechnology

authors： Daddam JR,Sreenivasulu B,Umamahesh K,Peddanna K,Rao DM

更新日期：2020-01-01 00:00:00

abstract：:Even though malnutrition is associated with an adverse prognosis after allogeneic stem cell transplantation, few studies have addressed the question what is the optimal nutritional support for these patients. There is a general agreement that the body weight, body mass index and nutritional intake can be used to guide...

journal_title：Current pharmaceutical biotechnology

authors： Tvedt TH,Reikvam H,Bruserud Ø

更新日期：2016-01-01 00:00:00

abstract：: ...

journal_title：Current pharmaceutical biotechnology

authors： Blum K,Baron D

更新日期：2019-01-01 00:00:00

abstract：:X-ray is a non-thermal technology that has shown good efficacy in reducing pathogenic and spoilage bacteria, viruses and parasites. X-ray hygiene technology resulted in a high microbial loss in numerous food products, such as dairy products, ready-to-eat shrimp, oysters, fresh products, strawberries, shredded iceberg ...

journal_title：Current pharmaceutical biotechnology

authors： Zehi ZB,Afshari A,Noori SMA,Jannat B,Hashemi M

更新日期：2020-01-01 00:00:00

abstract：:This mini-review describes how single-molecule sensitive fluorescence resonance energy transfer (FRET) and photoinduced electron transfer (PET) reactions can be successfully applied to monitor conformational dynamics in biopolymers. Single-pair FRET experiments are ideally suited to study conformational dynamics occur...

journal_title：Current pharmaceutical biotechnology

authors： Neuweiler H,Sauer M

更新日期：2004-06-01 00:00:00

abstract：:Fc-based therapeutics including therapeutic full-size monoclonal antibodies (mAbs) and Fcfusion proteins represent fastest-growing market in biopharmaceutical industrial. However, one major challenge during development of Fc-based therapeutics is how to maintain their efficacy in clinic use. Many factors may lead to f...

journal_title：Current pharmaceutical biotechnology

authors： Chen X,Zeng F,Huang T,Cheng L,Liu H,Gong R

更新日期：2016-01-01 00:00:00