Optimizing therapy for Acinetobacter baumannii.

abstract：:Cystic fibrosis (CF) is a complicated disease involving many organ systems. Identification of the cystic fibrosis transmembrane regulator (CFTR) genetic code has not only enhanced our understanding of the mechanism of CF pathology but has also provided explanations for phenotypic variation. Additionally, genetic testi...

journal_title：Seminars in respiratory and critical care medicine

authors： Lommatzsch ST,Aris R

更新日期：2009-10-01 00:00:00

abstract：:Community-acquired pneumonia (CAP) is associated with significant morbidity and mortality in Latin America and the Caribbean (LAC) region. Poverty, socioeconomic factors, and malnutrition influence the incidence and outcome of CAP in LAC. In LAC, Streptococcus pneumoniae is the most frequent microorganism responsible ...

journal_title：Seminars in respiratory and critical care medicine

authors： Iannella HA,Luna CM

更新日期：2016-12-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease of unknown cause, occurring in adults, limited to the lungs and associated with the pathologic and radiologic pattern of usual interstitial pneumonia. Prognosis is poor, and most patients die of respiratory failure within 3 to 6 years from the o...

journal_title：Seminars in respiratory and critical care medicine

authors： Puglisi S,Torrisi SE,Giuliano R,Vindigni V,Vancheri C

更新日期：2016-06-01 00:00:00

abstract：:Multiorgan dysfunction syndrome represents a continuum of cumulative organ dysfunction from very mildly altered function to total and, rarely, irreversible organ failure and is the major cause of death in the intensive care unit (ICU). The terms multiple organ failure syndrome (MOFS), multiple organ system failure (MO...

journal_title：Seminars in respiratory and critical care medicine

authors： Ferreira AM,Sakr Y

更新日期：2011-10-01 00:00:00

abstract：:Intensive care unit (ICU) acquired pneumonia is one of the most common and morbid health care-associated infections. Despite decades of work developing and testing prevention strategies, ICU-acquired pneumonia remains stubbornly pervasive. Pneumonia prevention studies are difficult to interpret because all are at risk...

journal_title：Seminars in respiratory and critical care medicine

authors： Klompas M

更新日期：2019-08-01 00:00:00

abstract：:In endemic areas, dimorphic fungal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides posadasii/immitis account for up to 30% of cases of community-acquired pneumonia. Because respiratory manifestations are often indistinguishable from common bacterial causes of pneumonia, the diagnos...

journal_title：Seminars in respiratory and critical care medicine

authors： Azar MM,Malo J,Hage CA

更新日期：2020-08-01 00:00:00

abstract：:This review summarizes the effects of beta2-agonists on asthma severity. There has been a controversy as to whether the regularly scheduled use of beta2-adrenergic agonists increases the risk of adverse outcomes in asthma. A number of epidemiological and clinical studies have found an association between the regularly...

journal_title：Seminars in respiratory and critical care medicine

authors： Ford JG,Iqbal J,Sunmonu Y

更新日期：2002-08-01 00:00:00

abstract：:The median age of presentation with lung cancer is 71, making the elderly the dominant subgroup. Although some elderly patients are frail, others have great physiological reserve. Geriatric assessment can clarify the specific strengths and weaknesses of older patients, improving management. This assessment should, at ...

journal_title：Seminars in respiratory and critical care medicine

authors： Weiss J,Langer C

更新日期：2013-12-01 00:00:00

abstract：:The elderly are especially prone to the adverse health effects of chronic obstructive pulmonary disease (COPD), which is a common disorder in that population. While the prevalence and morbidity of COPD in the elderly are high, it is often undiagnosed and thus undertreated. The diagnosis of COPD is primarily based on t...

journal_title：Seminars in respiratory and critical care medicine

authors： Hanania NA,Sharma G,Sharafkhaneh A

更新日期：2010-10-01 00:00:00

abstract：:Oral corticosteroids are powerful relatively nonspecific antiinflammatory agents with a range of well-characterized side effects. There is good evidence to show that they accelerate the rate of resolution of exacerbations of COPD and relapse is less likely if patients receive these drugs. Maintenance therapy with oral...

journal_title：Seminars in respiratory and critical care medicine

authors： Calverley PM

更新日期：2005-04-01 00:00:00

abstract：:Cystic fibrosis (CF) is a multisystem disease. Some of this is accounted for by CF transmembrane regulator (CFTR) dysfunction in individual organs but in some cases this is compounded by the effects of systemic inflammation. The inflammation is in response to the chronic infection in the airways and is particularly im...

journal_title：Seminars in respiratory and critical care medicine

authors： Elborn JS

更新日期：2007-06-01 00:00:00

abstract：:The genus Scedosporium comprises a group of filamentous fungi found ubiquitously in the environment. The two major human pathogens within this genus are S. apiospermum-the asexual state of Pseudallescheria boydii-and S. prolificans. Both histologically resemble Aspergillus species, with hyphae that are septated and br...

journal_title：Seminars in respiratory and critical care medicine

authors： Panackal AA,Marr KA

更新日期：2004-04-01 00:00:00

abstract：:Sarcoidosis is an immune-mediated systemic syndrome of unknown etiology. The treatment of the granulomatous inflammation in sarcoidosis is thus dependent on nonspecific suppression of the immune response. Although steroid-sparing approaches have moved to front-line therapy for many other immune-mediated inflammatory d...

journal_title：Seminars in respiratory and critical care medicine

authors： Lazar CA,Culver DA

更新日期：2010-08-01 00:00:00

abstract：:Nonspecific interstitial pneumonia (NSIP) represents one histologic subtype of idiopathic interstitial pneumonia (IIP). NSIP is typified by temporal homogeneity and less profusion of fibroblastic foci than is seen with usual interstitial pneumonia (UIP), the most common IIP. Clinically patients with NSIP present with ...

journal_title：Seminars in respiratory and critical care medicine

authors： Flaherty KR,Martinez FJ,Travis W,Lynch JP 3rd

更新日期：2001-08-01 00:00:00

abstract：:The diaphragm is the most important muscle of ventilation. Its contraction is key to the development of intrathoracic pressures. Diseases that affect diaphragmatic function result in decreased pressure-generating capacity by the respiratory muscles. If the involvement is severe or if there is underlying respiratory pa...

journal_title：Seminars in respiratory and critical care medicine

authors： Celli BR

更新日期：2002-06-01 00:00:00

abstract：:Coccidioidomycosis manifests as a variety of clinical manifestations and ranges in severity from asymptomatic exposure with resultant immunity to reinfection, to fulminant, and life-threatening disseminated disease. Primary coccidioidal pneumonia represents the most common clinical form of infection, and the incidence...

journal_title：Seminars in respiratory and critical care medicine

authors： Twarog M,Thompson GR 3rd

更新日期：2015-10-01 00:00:00

abstract：:Computed tomography (CT) is the core imaging modality for the evaluation of thoracic disorders. With the recently developed dual-energy CT (DECT) technique, the clinical utility of CT in the management of pulmonary diseases can be expanded. The most actively investigated principle of dual energy is material decomposit...

journal_title：Seminars in respiratory and critical care medicine

authors： Remy-Jardin M,Faivre JB,Pontana F,Molinari F,Tacelli N,Remy J

更新日期：2014-02-01 00:00:00

abstract：:This review provides an update on literature published over the past 5 years that is relevant to using chest computed tomography (CT) as a tool for preventing occupational respiratory disease. An important area of investigation has been in the use of low-dose CT (LDCT) to screen asbestos-exposed populations for lung c...

journal_title：Seminars in respiratory and critical care medicine

authors： Weissman DN

更新日期：2015-06-01 00:00:00

abstract：:Pain is experienced by the overwhelming majority of patients during their intensive care unit stay, but it remains an underappreciated problem. To effectively treat pain, it must be detected and quantified using a validated assessment tool. It is acknowledged that optimal pain relief may be difficult to achieve given ...

journal_title：Seminars in respiratory and critical care medicine

authors： Joffe AM,Hallman M,Gélinas C,Herr DL,Puntillo K

更新日期：2013-04-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer and the leading cause of cancer-related death. Although durable local control rates are high after surgical resection or definitive radiotherapy for early-stage disease, a substantial proportion of these patients eventually experience regiona...

journal_title：Seminars in respiratory and critical care medicine

authors： Dams RV,Yuan Y,Robinson CG,Lee P

更新日期：2020-06-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a common chronic autoimmune disorder that characteristically causes joint inflammation and damage. In addition, many patients develop extraarticular manifestations which may cause significant comorbidity and premature mortality.Some respiratory tract involvement of the upper and lower airw...

journal_title：Seminars in respiratory and critical care medicine

authors： Farquhar H,Vassallo R,Edwards AL,Matteson EL

更新日期：2019-04-01 00:00:00

abstract：:Catheters are the leading source of bloodstream infections in critically ill patients. Because the clinical signs of infection are nonspecific, such infections are overly suspected, which results in unnecessary removal of catheters. A conservative approach might be attempted in mild infections, whereas catheters shoul...

journal_title：Seminars in respiratory and critical care medicine

authors： Timsit JF,Dubois Y,Minet C,Bonadona A,Lugosi M,Ara-Somohano C,Hamidfar-Roy R,Schwebel C

更新日期：2011-04-01 00:00:00

abstract：:Cardiopulmonary resuscitation (CPR) is performed frequently by paramedics, emergency department personnel, and inpatient physicians. Unfortunately, after more than 40 years of practice and study, there are still many controversies and unresolved treatment issues. This article focuses on four current controversies in C...

journal_title：Seminars in respiratory and critical care medicine

authors： White SJ,Himes D,Rouhani M,Slovis CM

更新日期：2001-01-01 00:00:00

abstract：:Among immunocompromised individuals, members of the human Herpesviridae family are frequently encountered pathogens. Cytomegalovirus, herpes simplex virus 1 and 2, varicella zoster virus, Epstein-Barr virus, and human herpesvirus-6, -7, and -8 all establish latency after infection and can reactivate during periods of ...

journal_title：Seminars in respiratory and critical care medicine

authors： Reid GE,Lynch JP 3rd,Weigt S,Sayah D,Belperio JA,Grim SA,Clark NM

更新日期：2016-08-01 00:00:00

abstract：:Ultrasonography of the thorax has become a more recognized tool in pulmonary medicine, thanks to continuing clinical research that has proven its many valuable roles in the day-to-day management of pulmonary and pleural diseases. Ultrasound examination is a cost-effective imaging modality that permits the pulmonologis...

journal_title：Seminars in respiratory and critical care medicine

authors： Shojaee S,Argento AC

更新日期：2014-12-01 00:00:00

abstract：:Nonneoplastic pulmonary lymphoid disorders consist of a complex spectrum of diseases for pathologists and pulmonologists alike. Advances in our understanding of these disorders in recent years have led to revisions in the classification scheme. This review summarizes the clinicoradiological and pathological features o...

journal_title：Seminars in respiratory and critical care medicine

authors： Tian X,Yi ES,Ryu JH

更新日期：2012-10-01 00:00:00

abstract：:Aspirin-exacerbated respiratory disease (AERD) is a unique syndrome of airway inflammation that frequently occurs in patients with nasal polyposis, chronic sinusitis, and asthma. These patients tend to have progressive and recalcitrant sinus disease requiring frequent surgical intervention and in many cases systemic c...

journal_title：Seminars in respiratory and critical care medicine

authors： White AA,Stevenson DD

更新日期：2012-12-01 00:00:00

abstract：:Cor pulmonale frequently develops in patients with restrictive lung disease and neuromuscular disorders. Sleep disordered breathing, including nocturnal hypoventilation and obstructive apnea, has been associated with the development of cor pulmonale and may affect morbidity. The mechanisms responsible for sleep disord...

journal_title：Seminars in respiratory and critical care medicine

authors： Krachman SL,Criner GJ,Chatila W

更新日期：2003-06-01 00:00:00

abstract：:Survivors of critical illness often experience long-lasting impairments in mental, cognitive, and physical functioning. Acute stress reactions and delusional memories appear to play an important role in psychological morbidity following critical illness, and few interventions exist to address these symptoms. This revi...

journal_title：Seminars in respiratory and critical care medicine

authors： Karnatovskaia LV,Philbrick KL,Parker AM,Needham DM

更新日期：2016-02-01 00:00:00

abstract：:The evolution of scientific investigation in acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) is replete with examples of effective bench-to-bedside transitions, pioneering research methodology, and international collaboration. This article highlights for clinicians a selection of challenges and ...

journal_title：Seminars in respiratory and critical care medicine

authors： Meade MO,Lamontagne F

更新日期：2013-08-01 00:00:00