Angiotensin II type 2 receptors facilitate reinnervation of phenol-lesioned vascular calcitonin gene-related peptide-containing nerves in rat mesenteric arteries.

abstract：:Glutamate, the main excitatory amino acid transmitter in the vertebrate brain is involved in the dynamic changes in protein repertoire that underlie synaptic plasticity. Activity-dependent differential expression patterns occur not only in neurons but also in glial cells. In fact, a membrane to nuclei signaling has be...

journal_title：Neuroscience

authors： González-Mejia ME,Morales M,Hernández-Kelly LC,Zepeda RC,Bernabé A,Ortega A

更新日期：2006-09-01 00:00:00

abstract：:Ca(v)2.1 channels mediate neurotransmitter release at the neuromuscular junction (NMJ) and at many central synapses. Mutations in the encoding gene, CACNA1A, are thus likely to affect neurotransmitter release. Previously, we generated mice carrying the R192Q mutation, associated with human familial hemiplegic migraine...

journal_title：Neuroscience

authors： Kaja S,van de Ven RC,Broos LA,Veldman H,van Dijk JG,Verschuuren JJ,Frants RR,Ferrari MD,van den Maagdenberg AM,Plomp JJ

更新日期：2005-01-01 00:00:00

abstract：:The long-term effects of intrastriatal injections of the agonist of N-methyl-D-aspartate receptors, quinolinic acid, have been extensively characterized. Much less is known, however, about the early molecular and neurochemical changes which occur within a few hours of the toxin injection. In the present study, we have...

journal_title：Neuroscience

authors： Bordelon YM,Chesselet MF

更新日期：1999-01-01 00:00:00

abstract：:Prialt, a synthetic version of Ca(v)2.2 antagonist ω-conotoxin MVIIA derived from Conus magus, is the first clinically approved voltage-gated calcium channel blocker for refractory chronic pain. However, due to the narrow therapeutic window and considerable side effects associated with systemic dosing, Prialt is only ...

journal_title：Neuroscience

authors： Patel R,Rutten K,Valdor M,Schiene K,Wigge S,Schunk S,Damann N,Christoph T,Dickenson AH

更新日期：2015-06-25 00:00:00

abstract：:The ultrastructure of rat neurohypophyses incubated in vitro was studied to investigate secretion-related changes that may be intrinsic to the isolated neurohypophysis and to establish the morphological integrity of this preparation. Neurohypophyses were incubated for 2 h in an in vitro chamber in medium of low (290 m...

journal_title：Neuroscience

authors： Perlmutter LS,Hatton GI,Tweedle CD

更新日期：1984-06-01 00:00:00

abstract：:In recent years, there has been a great deal of progress toward understanding the role of the striatum and dopamine in action selection. The advent of new animal models and the development of optical techniques for imaging and stimulating select neuronal populations have provided the means by which identified synapses...

journal_title：Neuroscience

authors： Surmeier DJ,Carrillo-Reid L,Bargas J

更新日期：2011-12-15 00:00:00

abstract：:In the present study, we used co-culture of astrocytes from one species with neurons from a different species to examine neuritic outgrowth. We include a focus on human cells. Three types of neuron were used, including rat hippocampal dentate granule cells, rat hypothalamic neurons and human cortical neurons. To visua...

journal_title：Neuroscience

authors： van den Pol AN,Spencer DD

更新日期：2000-01-01 00:00:00

abstract：:Simvastatin is an HMG-CoA reductase inhibitor commonly used in the clinic to treat hypercholesterolemia. In addition, simvastatin has been shown to cross the blood-brain barrier and pleiotropic effects of simvastatin have been reported including anti-inflammatory properties, enhancement of neurite outgrowth, and memor...

journal_title：Neuroscience

authors： Métais C,Hughes B,Herron CE

更新日期：2015-04-16 00:00:00

abstract：:We have investigated a potential mechanism by which a diet, similar in composition to the typical diet of most industrialized western societies rich in saturated fat and refined sugar (HFS), can influence brain structure and function via regulation of neurotrophins. We show that animals that learn a spatial memory tas...

journal_title：Neuroscience

authors： Molteni R,Barnard RJ,Ying Z,Roberts CK,Gómez-Pinilla F

更新日期：2002-01-01 00:00:00

abstract：:We have recently identified a third subtype of glutamate vesicular transporter (VGLUT) named VGLUT3. In the present study, we provide a detailed account of the regional and cellular distributions of VGLUT3 in the rat brain, using specific nucleotide probes and antisera. The distribution of VGLUT3 protein was compared ...

journal_title：Neuroscience

authors： Herzog E,Gilchrist J,Gras C,Muzerelle A,Ravassard P,Giros B,Gaspar P,El Mestikawy S

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Psychiatric illness and anxiety disorders have strong neurodevelopmental components. Environmental insults such as prenatal exposure to stress and genetic differences in stress responses may affect brain development. METHODS:A rat model of random variable prenatal stress was used to study the expression and...

journal_title：Neuroscience

authors： Neeley EW,Berger R,Koenig JI,Leonard S

更新日期：2011-07-28 00:00:00

abstract：:The enzyme choline-O-acetyltransferase catalyses the biosynthesis of acetylcholine from acetyl coenzyme A and choline and is considered as one of the best markers for cholinergic nerve endings. The distribution of this enzymatic activity was analysed during the purification of plasma membranes of purely cholinergic ne...

journal_title：Neuroscience

authors： Eder-Colli L,Amato S

更新日期：1985-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the accumulation and deposition of plaques of amyloid-β (Aβ) peptide in the brain. Growing epidemiological and experimental studies have shown that 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) exerts neuroprotection against AD. However, the underlying mechanisms of the action rem...

journal_title：Neuroscience

authors： Guo YX,He LY,Zhang M,Wang F,Liu F,Peng WX

更新日期：2016-05-13 00:00:00

abstract：:Seizures and status epilepticus induce an excessive production of reactive oxygen species leading to oxidative stress. Vitamin E, a classic antioxidant, has a neuroprotective effect on rats with seizures by regulating reactive oxygen species production. The activity of chaperone-mediated autophagy, a selective pathway...

journal_title：Neuroscience

authors： Cao L,Chen R,Xu J,Lin Y,Wang R,Chi Z

更新日期：2009-06-16 00:00:00

abstract：:The distribution of different metabotropic glutamate receptors (mGluRs 1a, 1b, 1c, 2/3, 4 and 5) has been compared in the superior colliculus of the rat, cat and ferret using immunohistochemical techniques and light microscopy. We found that although there are differences in labelling patterns between the species, the...

journal_title：Neuroscience

authors： Cirone J,Sharp C,Jeffery G,Salt TE

更新日期：2002-01-01 00:00:00

abstract：:The distributions of the alpha 1-adrenoceptor and its subtypes (alpha 1A and alpha 1B) in human and rat hippocampus are analysed by quantitative receptor autoradiography. alpha 1-Adrenoceptors are labelled by [3H]prazosin. The alpha 1A subtype is visualized by [3H]prazosin after irreversible blockade of alpha 1B adren...

journal_title：Neuroscience

authors： Zilles K,Gross G,Schleicher A,Schildgen S,Bauer A,Bahro M,Schwendemann G,Zech K,Kolassa N

更新日期：1991-01-01 00:00:00

abstract：:It is well established that the supramammillary nucleus plays a critical role in hippocampal theta rhythm generation/regulation by its direct and indirect (via the septal complex) connections to the hippocampus. Previous morphological and electrophysiological studies indicate that both the supramammillo-hippocampal an...

journal_title：Neuroscience

authors： Kiss J,Csáki A,Bokor H,Shanabrough M,Leranth C

更新日期：2000-01-01 00:00:00

abstract：:The medial thalamus contains abundant mu-opioid receptors and is activated by acute morphine administration. However, the role of the medial thalamus in the rewarding effects of morphine is unclear. The present study examined whether mu-opioid receptors of the medial thalamus influenced the acquisition and expression ...

journal_title：Neuroscience

authors： Guo N,Garcia MM,Taylor BK,Zadina JE,Harlan RE

更新日期：2008-02-19 00:00:00

abstract：:Pathological changes occur in areas of CNS tissue remote from inflammatory lesions in multiple sclerosis (MS) and its animal model experimental allergic encephalomyelitis (EAE). To determine if oxidative stress is a significant contributor to this non-inflammatory pathology, cortex tissues from mice with clinical sign...

journal_title：Neuroscience

authors： Castegna A,Palmieri L,Spera I,Porcelli V,Palmieri F,Fabis-Pedrini MJ,Kean RB,Barkhouse DA,Curtis MT,Hooper DC

更新日期：2011-06-30 00:00:00

abstract：:Peptide YY immunoreactivity was detected in neuronal elements in the upper digestive tract of the rat, cat, ferret and pig by immunocytochemistry and radioimmunoassay combined with high-performance liquid chromatography. The two peptide YY antisera used do not recognize the related peptides neuropeptide Y and pancreat...

journal_title：Neuroscience

authors： Böttcher G,Ekblad E,Ekman R,Håkanson R,Sundler F

更新日期：1993-07-01 00:00:00

abstract：:On mating with a stud male, virgin female mice from an olfactory memory to this male which is essential to their reproductive success. Failure to form this memory results in the stud male being treated as strange, and hence, his pheromones block pregnancy. This study investigates the duration of the olfactory memory, ...

journal_title：Neuroscience

authors： Kaba H,Rosser AE,Keverne EB

更新日期：1988-01-01 00:00:00

abstract：:Acute osmolar loading of cerebrospinal fluid within one lateral ventricle of dogs was examined as a cause of water extraction from the bloodstream and an increase in intracranial pressure. We have shown that a certain amount of (3)H₂O from the bloodstream enters osmotically loaded cerebrospinal fluid significantly fas...

journal_title：Neuroscience

authors： Klarica M,Miše B,Vladić A,Radoš M,Orešković D

更新日期：2013-09-17 00:00:00

abstract：:Carbachol, a long-acting cholinergic agonist, was microinjected (4 micrograms/250 nl per 90 s) into 90 sites within the anterodorsal pontine tegmentum of four cats and the time to onset and percentage of time spent in a desynchronized sleep-like state during 40 min postinjection were calculated. Compared with more pos...

journal_title：Neuroscience

authors： Yamamoto K,Mamelak AN,Quattrochi JJ,Hobson JA

更新日期：1990-01-01 00:00:00

abstract：:It has been proposed that glutamatergic and dopaminergic systems are functionally opposed in their regulation of striatal output. The present study tested the effects of drugs that enhance AMPA-receptor-mediated glutamatergic transmission (ampakines) for their effects on dopamine-related alterations in cortical activi...

journal_title：Neuroscience

authors： Hess US,Whalen SP,Sandoval LM,Lynch G,Gall CM

更新日期：2003-01-01 00:00:00

abstract：:Effects of L-arginine in the nervous system are often attributed to nitric oxide. Using whole-cell patch pipettes to record membrane currents in voltage-clamp from dopamine neurons in the rat midbrain slice, the present studies found that L-arginine potentiates GABA-dependent membrane currents via a nitric oxide-indep...

journal_title：Neuroscience

authors： Shen KZ,Cox BA,Johnson SW

更新日期：1997-08-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive aging disorder that affects millions worldwide, thus, disease-modifying-therapies are urgently needed. PD pathology includes α-synuclein (aSyn) accumulation as synucleinopathy. Loss of GM1 gangliosides occurs in PD brain, which is modeled in GM2 synthase transgenic mice. GM2+/...

journal_title：Neuroscience

authors： Vidal-Martinez G,Najera K,Miranda JD,Gil-Tommee C,Yang B,Vargas-Medrano J,Diaz-Pacheco V,Perez RG

更新日期：2019-07-15 00:00:00

abstract：:Olvanil ((N-vanillyl)-9-oleamide), a non-pungent transient receptor potential vanilloid type 1 agonist, desensitizes nociceptors and alleviates pain. But its molecular targets and signaling mechanisms are little known. Calcium influx through voltage-activated Ca(2+) channels plays an important role in neurotransmitter...

journal_title：Neuroscience

authors： Wu ZZ,Chen SR,Pan HL

更新日期：2006-08-11 00:00:00

abstract：:Pathological forms of the microtubule-associated protein tau are involved in a large group of neurodegenerative diseases named tauopathies, including frontotemporal lobar degeneration (FTLD-tau). K369I mutant tau transgenic mice (K3 mice) recapitulate neural and behavioural symptoms of FTLD, including tau aggregates i...

journal_title：Neuroscience

authors： Mo M,Jönsson ME,Mathews MA,Johnstone D,Ke YD,Ittner LM,Balleine BW,Furlong TM,Camp AJ

更新日期：2020-11-21 00:00:00

abstract：:Major limitations to the pharmacotherapy of Parkinson's disease (PD) are the motor complications resulting from L-DOPA treatment. Abnormal involuntary movements (dyskinesia) affect a majority of the patients after a few years of L-DOPA treatment and can become troublesome and debilitating. Once dyskinesia has debuted,...

journal_title：Neuroscience

authors： Iderberg H,Francardo V,Pioli EY

更新日期：2012-06-01 00:00:00

abstract：:Administration of kainic acid induces acute seizures that result in the loss of neurons, gliosis and reorganization of mossy fiber pathways in the hippocampus resembling those observed in human temporal lobe epilepsy. Although these structural changes have been well characterized, the mechanisms underlying the degener...

journal_title：Neuroscience

authors： Banerjee M,Sasse VA,Wang Y,Maulik M,Kar S

更新日期：2015-01-22 00:00:00