The Hill-Robertson effect: evolutionary consequences of weak selection and linkage in finite populations.

Abstract:

:The 'Hill-Robertson (HR) effect' describes that linkage between sites under selection will reduce the overall effectiveness of selection in finite populations. Here we discuss the major concepts associated with the HR effect and present results of computer simulations focusing on the linkage effects generated by multiple sites under weak selection. Most models of linkage and selection forecast differences in effectiveness of selection between chromosomes or chromosomal regions involving a number of genes. The abundance and physical clustering of weakly selected mutations across genomes, however, justify the investigation of HR effects at a very local level and we pay particular attention to linkage effects among selected sites of the same gene. Overall, HR effects caused by weakly selected mutations predict differences in effectiveness of selection between genes that differ in exon-intron structures and across genes. Under this scenario, introns might play an advantageous role reducing intragenic HR effects. Finally, we summarize observations that are consistent with local HR effects in Drosophila, discuss potential consequences on population genetic studies and suggest future lines of research.

journal_name

Heredity (Edinb)

journal_title

Heredity

authors

Comeron JM,Williford A,Kliman RM

doi

10.1038/sj.hdy.6801059

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

19-31

issue

1

eissn

0018-067X

issn

1365-2540

pii

6801059

journal_volume

100

pub_type

杂志文章,评审

相关文献

HEREDITY文献大全
  • Herbicide resistance-endowing ACCase gene mutations in hexaploid wild oat (Avena fatua): insights into resistance evolution in a hexaploid species.

    abstract::Many herbicide-resistant weed species are polyploids, but far too little about the evolution of resistance mutations in polyploids is understood. Hexaploid wild oat (Avena fatua) is a global crop weed and many populations have evolved herbicide resistance. We studied plastidic acetyl-coenzyme A carboxylase (ACCase)-in...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2012.69

    authors: Yu Q,Ahmad-Hamdani MS,Han H,Christoffers MJ,Powles SB

    更新日期:2013-03-01 00:00:00

  • Recessive Z-linked lethals and the retention of haplotype diversity in a captive butterfly population.

    abstract::Sex chromosomes are predicted to harbour elevated levels of sexually antagonistic variation due to asymmetries in the heritability of recessive traits in the homogametic versus heterogametic sex. This evolutionary dynamic may manifest as high recessive load specifically affecting the homogametic sex, and the retention...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/s41437-020-0316-x

    authors: Saccheri IJ,Whiteford S,Yung CJ,Van't Hof AE

    更新日期:2020-08-01 00:00:00

  • Recent range expansion and agricultural landscape heterogeneity have only minimal effect on the spatial genetic structure of the plant pathogenic fungus Mycosphaerella fijiensis.

    abstract::Understanding how geographical and environmental features affect genetic variation at both the population and individual levels is crucial in biology, especially in the case of pathogens. However, distinguishing between these factors and the effects of historical range expansion on spatial genetic structure remains ch...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2012.55

    authors: Rieux A,De Lapeyre De Bellaire L,Zapater MF,Ravigne V,Carlier J

    更新日期:2013-01-01 00:00:00

  • Genetic mapping identifies a major locus spanning P450 clusters associated with pyrethroid resistance in kdr-free Anopheles arabiensis from Chad.

    abstract::Prevention of malaria transmission throughout much of Africa is dependent on bednets that are impregnated with pyrethroid insecticides. Anopheles arabiensis is the major malaria vector in Chad and efforts to control this vector are threatened by the emergence of pyrethroid resistance. WHO bioassays revealed that An. a...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2012.112

    authors: Witzig C,Parry M,Morgan JC,Irving H,Steven A,Cuamba N,Kerah-Hinzoumbé C,Ranson H,Wondji CS

    更新日期:2013-04-01 00:00:00

  • Making a long story short: noncoding RNAs and chromosome change.

    abstract::As important as the events that influence selection for specific chromosome types in the derivation of novel karyotypes, are the events that initiate the changes in chromosome number and structure between species, and likewise polymorphisms, variants and disease states within species. Although once thought of as trans...

    journal_title:Heredity

    pub_type: 杂志文章,评审

    doi:10.1038/hdy.2011.104

    authors: Brown JD,Mitchell SE,O'Neill RJ

    更新日期:2012-01-01 00:00:00

  • Genetic diversity and reproductive biology in ecotypes of the facultative apomict Hypericum perforatum L.

    abstract::Apomixis is a mode of asexual reproduction through seed. Progeny produced by apomixis are clonal replicas of a mother plant. The essential feature of apomixis is that embryo sacs and embryos are produced in ovules without meiotic reduction or egg cell fertilisation. Thus, apomixis fixes successful gene combinations an...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800808

    authors: Barcaccia G,Arzenton F,Sharbel TF,Varotto S,Parrini P,Lucchin M

    更新日期:2006-04-01 00:00:00

  • Genetic monitoring reveals temporal stability over 30 years in a small, lake-resident brown trout population.

    abstract::Knowledge of the degree of temporal stability of population genetic structure and composition is important for understanding microevolutionary processes and addressing issues of human impact of natural populations. We know little about how representative single samples in time are to reflect population genetic constit...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2012.36

    authors: Charlier J,Laikre L,Ryman N

    更新日期:2012-10-01 00:00:00

  • Inheritance of thelytoky in the honey bee Apis mellifera capensis.

    abstract::Asexual reproduction via thelytokous parthenogenesis is widespread in the Hymenoptera, but its genetic underpinnings have been described only twice. In the wasp Lysiphlebus fabarum and the Cape honey bee Apis mellifera capensis the origin of thelytoky have each been traced to a single recessive locus. In the Cape hone...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2014.127

    authors: Chapman NC,Beekman M,Allsopp MH,Rinderer TE,Lim J,Oxley PR,Oldroyd BP

    更新日期:2015-06-01 00:00:00

  • Dispersion of the Cf-4 disease resistance gene in Lycopersicon germplasm.

    abstract::In the past, numerous Cf genes have been reported in tomato (Lycopersicon esculentum Mill.) that confer resistance against leaf mould (Cladosporium fulvum Cke.). We are interested in genetic variation at Cf loci. Therefore, previously uncharacterized Cf genes were further analysed. Recognition of the AVR4 elicitor, DN...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.2000.00754.x

    authors: Haanstra JP,Thomas CM,Jones JD,Lindhout P

    更新日期:2000-09-01 00:00:00

  • Local adaptation for body color in Drosophila americana.

    abstract::Pigmentation is one of the most variable traits within and between Drosophila species. Much of this diversity appears to be adaptive, with environmental factors often invoked as selective forces. Here, we describe the geographic structure of pigmentation in Drosophila americana and evaluate the hypothesis that it is a...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2010.90

    authors: Wittkopp PJ,Smith-Winberry G,Arnold LL,Thompson EM,Cooley AM,Yuan DC,Song Q,McAllister BF

    更新日期:2011-04-01 00:00:00

  • A comparison of genomic selection models across time in interior spruce (Picea engelmannii × glauca) using unordered SNP imputation methods.

    abstract::Genomic selection (GS) potentially offers an unparalleled advantage over traditional pedigree-based selection (TS) methods by reducing the time commitment required to carry out a single cycle of tree improvement. This quality is particularly appealing to tree breeders, where lengthy improvement cycles are the norm. We...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2015.57

    authors: Ratcliffe B,El-Dien OG,Klápště J,Porth I,Chen C,Jaquish B,El-Kassaby YA

    更新日期:2015-12-01 00:00:00

  • A linkage map for the hybridising toads Bombina bombina and B. variegata (Anura: Discoglossidae).

    abstract::Stable hybrid zones in which ecologically divergent taxa give rise to a range of recombinants are natural laboratories in which the genetic basis of adaptation and reproductive isolation can be unraveled. One such hybrid zone is formed by the fire-bellied toads Bombina bombina and B. variegata (Anura: Discoglossidae)....

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800291

    authors: Nürnberger B,Hofman S,Förg-Brey B,Praetzel G,Maclean A,Szymura JM,Abbott CM,Barton NH

    更新日期:2003-08-01 00:00:00

  • Patterns of pollen dispersal in a small population of Pinus sylvestris L. revealed by total-exclusion paternity analysis.

    abstract::Patterns of pollen dispersal were investigated in a small, isolated, relict population of Pinus sylvestris L., consisting of 36 trees. A total-exclusion battery comprising four chloroplast and two nuclear microsatellites (theoretical paternity exclusion probability EP=0.996) was used to assign paternity to 813 seeds, ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800542

    authors: Robledo-Arnuncio JJ,Gil L

    更新日期:2005-01-01 00:00:00

  • Genetic variation in the vulnerable and endemic Monkey Puzzle tree, detected using RAPDs.

    abstract::Araucaria araucana (Monkey Puzzle), a southern South American tree species of exceptional cultural and economic importance, is of conservation concern owing to extensive historical clearance and current human pressures. Random amplified polymorphic DNA (RAPD) markers were used to characterise genetic heterogeneity wit...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800033

    authors: Bekessy SA,Allnutt TR,Premoli AC,Lara A,Ennos RA,Burgman MA,Cortes M,Newton AC

    更新日期:2002-04-01 00:00:00

  • Detection of rare paternal chloroplast inheritance in controlled crosses of the endangered sunflower Helianthus verticillatus.

    abstract::A variety of questions in population and evolutionary biology are studied using chloroplast DNA (cpDNA). The presumed maternal inheritance in angiosperms allows for certain assumptions and calculations to be made when studying plant hybridization, phylogeography, molecular systematics and seed dispersal. Further, the ...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2008.11

    authors: Ellis JR,Bentley KE,McCauley DE

    更新日期:2008-06-01 00:00:00

  • Contemporary and historic factors influence differently genetic differentiation and diversity in a tropical palm.

    abstract::Population genetics theory predicts loss in genetic variability because of drift and inbreeding in isolated plant populations; however, it has been argued that long-distance pollination and seed dispersal may be able to maintain gene flow, even in highly fragmented landscapes. We tested how historical effective popula...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2015.30

    authors: da Silva Carvalho C,Ribeiro MC,Côrtes MC,Galetti M,Collevatti RG

    更新日期:2015-09-01 00:00:00

  • Cooperation and conflict in the evolution of multicellularity.

    abstract::Multicellular organisms probably originated as groups of cells formed in several ways, including cell proliferation from a group of founder cells and aggregation. Cooperation among cells benefits the group, but may be costly (altruistic) or beneficial (synergistic) to individual cooperating cells. In this paper, we st...

    journal_title:Heredity

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2540.2001.00808.x

    authors: Michod RE,Roze D

    更新日期:2001-01-01 00:00:00

  • Sex ratios.

    abstract::Sex ratio theory attempts to explain variation at all levels (species, population, individual, brood) in the proportion of offspring that are male (the sex ratio). In many cases this work has been extremely successful, providing qualitative and even quantitative explanations of sex ratio variation. However, this is no...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800018

    authors: West SA,Reece SE,Sheldon BC

    更新日期:2002-02-01 00:00:00

  • Absence of dosage compensation at the transcription level of a sex-linked gene in a female heterogametic insect, Bombyx mori.

    abstract::To confirm whether sex-linked genes of the silkworm are dosage compensated or not, we investigated three RAPDs and one RFLP marker which have been mapped to the Z chromosome as candidate genes to test for dosage compensation. Northern blot analysis demonstrated that one of the RAPDs, T15.180a, is transcribed into seve...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.1998.00356.x

    authors: Suzuki MG,Shimada T,Kobayashi M

    更新日期:1998-09-01 00:00:00

  • The effect of cultural transmission on continuous variation.

    abstract::Cultural transmission may depend on the non-genetic transfer of information from parent to offspring. The consequences of such cultural transmission for continuous variation are investigated theoretically for randomly mating populations. Cultural inheritance may act on genetical and environmental differences between i...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.1976.64

    authors: Eaves L

    更新日期:1976-08-01 00:00:00

  • Modelling the co-evolution of indirect genetic effects and inherited variability.

    abstract::When individuals interact, their phenotypes may be affected not only by their own genes but also by genes in their social partners. This phenomenon is known as Indirect Genetic Effects (IGEs). In aquaculture species and some plants, however, competition not only affects trait levels of individuals, but also inflates v...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/s41437-018-0068-z

    authors: Marjanovic J,Mulder HA,Rönnegård L,Bijma P

    更新日期:2018-12-01 00:00:00

  • Lineage-specific mapping of quantitative trait loci.

    abstract::We present an approach for quantitative trait locus (QTL) mapping, termed as 'lineage-specific QTL mapping', for inferring allelic changes of QTL evolution along with branches in a phylogeny. We describe and analyze the simplest case: by adding a third taxon into the normal procedure of QTL mapping between pairs of ta...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2013.24

    authors: Chen C,Ritland K

    更新日期:2013-08-01 00:00:00

  • Segregation distortion and the evolution of sex-determining mechanisms.

    abstract::Segregation distorters are alleles that distort normal segregation in their own favour. Sex chromosomal distorters lead to biased sex ratios, and the presence of such distorters, therefore, may induce selection for a change in the mechanism of sex determination. The evolutionary dynamics of distorter-induced changes i...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2009.104

    authors: Kozielska M,Weissing FJ,Beukeboom LW,Pen I

    更新日期:2010-01-01 00:00:00

  • Comparative mRNA and miRNA expression in European mouflon (Ovis musimon) and sheep (Ovis aries) provides novel insights into the genetic mechanisms for female reproductive success.

    abstract::Prolific breeds of domestic sheep (Ovis aries) are important genetic resources due to their reproductive performance, which is characterized by multiple lambs per birth and out-of-season breeding. However, the lack of a comprehensive understanding of the genetic mechanisms underlying the important reproductive traits,...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/s41437-018-0090-1

    authors: Yang J,Li X,Cao YH,Pokharel K,Hu XJ,Chen ZH,Xu SS,Peippo J,Honkatukia M,Kantanen J,Li MH

    更新日期:2019-02-01 00:00:00

  • Do polymorphic loci require large sample sizes to estimate genetic distances?

    abstract::The coefficient of variation of estimates of three genetic distances (standard genetic distance of Nei, chord distance, FST) was examined with computer simulation to determine if large samples (per population) are necessary to precisely estimate genetic distances at loci with high levels of polymorphism. These simulat...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800548

    authors: Kalinowski ST

    更新日期:2005-01-01 00:00:00

  • Evolutionary implications of the relationship between genome size and body size in flatworms and copepods.

    abstract::Genome and body sizes were measured in 38 species of turbellarian flatworms and 16 species of copepod crustaceans. Significant positive relationships existed between genome size and body size in both groups. The slopes of these regressions indicated that increases in cell volume are reinforced by increased cell number...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1046/j.1365-2540.2000.00661.x

    authors: Gregory TR,Hebert PD,Kolasa J

    更新日期:2000-02-01 00:00:00

  • Genetic resource impacts of habitat loss and degradation; reconciling empirical evidence and predicted theory for neotropical trees.

    abstract::The theoretical impacts of anthropogenic habitat degradation on genetic resources have been well articulated. Here we use a simulation approach to assess the magnitude of expected genetic change, and review 31 studies of 23 neotropical tree species to assess whether empirical case studies conform to theory. Major diff...

    journal_title:Heredity

    pub_type: 杂志文章,评审

    doi:10.1038/sj.hdy.6800725

    authors: Lowe AJ,Boshier D,Ward M,Bacles CF,Navarro C

    更新日期:2005-10-01 00:00:00

  • Genetic differentiation in spite of high gene flow in the dominant rainforest tree of southeastern Australia, Nothofagus cunninghamii.

    abstract::Nothofagus cunninghamii is a long-lived, wind-pollinated tree species that dominates the cool temperate rainforests of southeastern Australia. The species' distribution is more or less continuous in western Tasmania but is fragmented elsewhere. However, it is unknown whether this fragmentation has affected the species...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/hdy.2015.77

    authors: Duncan CJ,Worth JR,Jordan GJ,Jones RC,Vaillancourt RE

    更新日期:2016-01-01 00:00:00

  • Heritability of nectar production in Echium vulgare.

    abstract::Heritabilities of nectar production in the wild species Echium vulgare were estimated as realised heritability under controlled and field conditions. The nectar production of offspring from high- and low-nectar-producing parents was significantly different in both controlled and field conditions, indicating that necta...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800439

    authors: Leiss KA,Vrieling K,Klinkhamer PG

    更新日期:2004-05-01 00:00:00

  • Microsatellite DNA variation reveals high gene flow and panmictic populations in the Adriatic shared stocks of the European squid and cuttlefish (Cephalopoda).

    abstract::In the semienclosed Adriatic Sea, the shared stocks of the cephalopods Loligo vulgaris and Sepia officinalis represent important marine fisheries resources exploited by all coastal countries. The improving of knowledge on the demographic features of these shared stocks is internationally relevant for adopting responsi...

    journal_title:Heredity

    pub_type: 杂志文章

    doi:10.1038/sj.hdy.6800489

    authors: Garoia F,Guarniero I,Ramsak A,Ungaro N,Landi M,Piccinetti C,Mannini P,Tinti F

    更新日期:2004-08-01 00:00:00